Multiple irradiation sensing of the optical effective attenuation coefficient for spectral correction in handheld OA imaging

Held, Kai Gerrit; Jaeger, Michael; Ricka, Jaroslav; Frenz, Martin; Akarçay, Hidayet Günhan (2016). Multiple irradiation sensing of the optical effective attenuation coefficient for spectral correction in handheld OA imaging. Photoacoustics, 4(2), pp. 70-80. Elsevier 10.1016/j.pacs.2016.05.004

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Spectral optoacoustic (OA) imaging enables spatially-resolved measurement of blood oxygenation levels, based on the distinct optical absorption spectra of oxygenated and de-oxygenated blood. Wavelength-dependent optical attenuation in the bulk tissue, however, distorts the acquired OA spectrum and thus makes quantitative oxygenation measurements challenging. We demonstrate a correction for this spectral distortion without requiring a priori knowledge of the tissue optical properties, using the concept of multiple irradiation sensing: recording the OA signal amplitude of an absorbing structure (e.g. blood vessel), which serves as an intrinsic fluence detector, as function of irradiation position. This permits the reconstruction of the bulk effective optical attenuation coefficient μeff,λ. If performed at various irradiation wavelengths, a correction for the wavelength-dependent fluence attenuation is achieved, revealing accurate spectral information on the absorbing structures. Phantom studies were performed to show the potential of this technique for handheld clinical combined OA and ultrasound imaging.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Institute of Applied Physics
08 Faculty of Science > Institute of Applied Physics > Biomedical Photonics

UniBE Contributor:

Held, Kai Gerrit; Jaeger, Michael; Ricka, Jaroslav; Frenz, Martin and Akarçay, Hidayet Günhan

Subjects:

600 Technology > 620 Engineering
500 Science
500 Science > 530 Physics

ISSN:

2213-5979

Publisher:

Elsevier

Language:

English

Submitter:

Simone Corry

Date Deposited:

13 Jul 2017 09:46

Last Modified:

13 Jul 2017 09:46

Publisher DOI:

10.1016/j.pacs.2016.05.004

BORIS DOI:

10.7892/boris.96959

URI:

https://boris.unibe.ch/id/eprint/96959

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