Pharmacology of ORAI channels as a tool to understand their physiological functions.

Bogeski, Ivan; Al-Ansary, Dalia; Qu, Bin; Niemeyer, Barbara A; Hoth, Markus; Peinelt, Christine (2010). Pharmacology of ORAI channels as a tool to understand their physiological functions. Expert review of clinical pharmacology, 3(3), pp. 291-303. Taylor & Francis 10.1586/ecp.10.23

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Store-operated Ca(2+) entry is a major Ca(2+) entry mechanism that is present in most cell types. In immune cells, store-operated Ca(2+) entry is almost exclusively mediated by Ca(2+) release-activated Ca(2+) (CRAC) channels. Ca(2+) entry through these channels and the corresponding cytosolic Ca(2+) signals are required for many immune cell functions, including all aspects of T-cell activation. ORAI proteins are the molecular correlates for the CRAC channels. The three human members, ORAI1, ORAI2 and ORAI3, are activated through the stromal interaction molecules (STIM)1 and 2 following depletion of endoplasmic reticulum Ca(2+) stores. Different combinations of STIM and ORAI can form different CRAC channels with distinct biophysical properties. In this article, we review and discuss mechanistic and functional implications of two important CRAC/ORAI inhibitors, 2-APB and BTP2, and the antibiotic G418 that has also been reported to interfere with ORAI channel function. The use of pharmacological tools should help to assign distinct physiological and pathophysiological functions to different STIM-ORAI protein complexes.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Biochemistry and Molecular Medicine

UniBE Contributor:

Peinelt, Christine

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

1751-2433

Publisher:

Taylor & Francis

Language:

English

Submitter:

Christine Peinelt

Date Deposited:

14 Jun 2018 10:03

Last Modified:

14 Jun 2018 10:04

Publisher DOI:

10.1586/ecp.10.23

PubMed ID:

22111611

BORIS DOI:

10.7892/boris.97459

URI:

https://boris.unibe.ch/id/eprint/97459

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