Peinelt, Christine; Vig, Monika; Koomoa, Dana L; Beck, Andreas; Nadler, Monica J S; Koblan-Huberson, Murielle; Lis, Annette; Fleig, Andrea; Penner, Reinhold; Kinet, Jean-Pierre (2006). Amplification of CRAC current by STIM1 and CRACM1 (Orai1). Nature cell biology, 8(7), pp. 771-773. Nature Publishing Group 10.1038/ncb1435
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Depletion of intracellular calcium stores activates store-operated calcium entry across the plasma membrane in many cells. STIM1, the putative calcium sensor in the endoplasmic reticulum, and the calcium release-activated calcium (CRAC) modulator CRACM1 (also known as Orai1) in the plasma membrane have recently been shown to be essential for controlling the store-operated CRAC current (I(CRAC)). However, individual overexpression of either protein fails to significantly amplify I(CRAC). Here, we show that STIM1 and CRACM1 interact functionally. Overexpression of both proteins greatly potentiates I(CRAC), suggesting that STIM1 and CRACM1 mutually limit store-operated currents and that CRACM1 may be the long-sought CRAC channel.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Biochemistry and Molecular Medicine |
UniBE Contributor: |
Peinelt, Christine |
Subjects: |
500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health |
ISSN: |
1465-7392 |
Publisher: |
Nature Publishing Group |
Language: |
English |
Submitter: |
Christine Peinelt |
Date Deposited: |
18 Jun 2018 09:37 |
Last Modified: |
05 Dec 2022 15:03 |
Publisher DOI: |
10.1038/ncb1435 |
PubMed ID: |
16733527 |
BORIS DOI: |
10.7892/boris.97466 |
URI: |
https://boris.unibe.ch/id/eprint/97466 |
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