Improved column-based radiochemical processing of the generator produced 68Ga

Loktionova, N. S.; Belozub, A. N.; Filosofov, D. V.; Zhernosekov, K. P.; Wagner, T.; Türler, A.; Rösch, F. (2011). Improved column-based radiochemical processing of the generator produced 68Ga. Applied radiation and isotopes, 69(7), pp. 942-946. Oxford: Pergamon 10.1016/j.apradiso.2011.02.035

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An improved chemical strategy for processing of the generator produced 68Ga was developed based on processing of the original 68Ge/68Ga generator eluate on a micro-column. Direct pre-concentration and purification of the eluted 68Ga is performed on a cation-exchange resin in hydrochloric acid/acetone media. A supplementary step based on a second micro-column filled with a second resin allows direct re-adsorption of 68Ga eluted from the cation exchanger. 68Ga is finally striped from the second resin with a small volume of pure water. For this purpose a strong anion exchanger and a novel extraction chromatographic resin based on tetraalkyldiglycolamides are characterized. The strategy allows online pre-concentration and purification of 68Ga from the original generator eluate. The supplementary column allows transferring 68Ga with high radionuclide and chemical quality in the aqueous solution with small volume and low acidity useful for direct radiolabeling reactions.

Item Type:	Journal Article (Original Article)
Division/Institute:	08 Faculty of Science > Department of Chemistry, Biochemistry and Pharmaceutical Sciences (DCBP)
UniBE Contributor:	Türler, Andreas
ISSN:	0969-8043
Publisher:	Pergamon
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:27
Last Modified:	05 Dec 2022 14:08
Publisher DOI:	10.1016/j.apradiso.2011.02.035
Web of Science ID:	000291456300005
URI:	https://boris.unibe.ch/id/eprint/9801 (FactScience: 215586)