Hemodynamic Characterization of Peripheral Arterio-venous Malformations

Frey, Sabrina; Haine, Axel; Kammer, Rafael Franz; Von Tengg-Kobligk, Hendrik; Obrist, Dominik; Baumgartner, Iris (2017). Hemodynamic Characterization of Peripheral Arterio-venous Malformations. Annals of biomedical engineering, 45(6), pp. 1449-1461. Springer 10.1007/s10439-017-1821-9

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Peripheral arterio-venous malformations (pAVMs) are congenital vascular anomalies that require treatment, due to their severe clinical consequences. The complexity of lesions often leads to misdiagnosis and ill-planned treatments. To improve disease management, we developed a computational model to quantify the hemodynamic effects of key angioarchitectural features of pAVMs. Hemodynamic results were used to predict the transport of contrast agent (CA), which allowed us to compare our findings to digital subtraction angiography (DSA) recordings of patients. The model is based on typical pAVM morphologies and a generic vessel network that represents realistic vascular feeding and draining components related to lesions. A lumped-parameter description of the vessel network was employed to compute blood pressure and flow rates. CA-transport was determined by coupling the model to a 1D advection–diffusion equation. Results show that the extent of hemodynamic effects of pAVMs, such as arterial steal and venous hypertension, strongly depends on the lesion type and its vascular architecture. Dimensions of shunting vessels strongly influence hemodynamic parameters. Our results underline the importance of the dynamics of CA-transport in diagnostic DSA images. In this context, we identified a set of temporal CA-transport parameters, which are indicative of the presence and specific morphology of pAVMs.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Angiology
10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Cardiovascular Engineering (CVE)
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Frey, Sabrina; Haine, Axel; Kammer, Rafael Franz; Von Tengg-Kobligk, Hendrik; Obrist, Dominik and Baumgartner, Iris

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health
600 Technology > 620 Engineering

ISSN:

0090-6964

Publisher:

Springer

Language:

English

Submitter:

Sabrina Frey

Date Deposited:

17 Aug 2017 16:14

Last Modified:

17 Aug 2017 16:14

Publisher DOI:

10.1007/s10439-017-1821-9

PubMed ID:

28324193

BORIS DOI:

10.7892/boris.98597

URI:

https://boris.unibe.ch/id/eprint/98597

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