A Clinical and Radiological Approach to the Management of Benign Mesenchymal Sinonasal Tumors.

Anschütz, Lukas Peter; Buchwalder, Melanie; Dettmer, Matthias; Caversaccio, Marco; Wagner, Franca (2017). A Clinical and Radiological Approach to the Management of Benign Mesenchymal Sinonasal Tumors. ORL, 79(3), pp. 131-146. Karger 10.1159/000468945

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PURPOSE Benign mesenchymal sinonasal neoplasms (BMSN) are rare and histologically heterogeneous. Differential diagnosis, appropriate management, and outcome are still a matter of debate. The aim of this study is to provide evidence for further refinement of assessment and treatment in the future. PROCEDURES We retrospectively reviewed data on 93 patients with neuroradiologically verified BMSN treated at our university reference center during the past 22 years. RESULTS The most frequent BMSN recorded in our cohort was osteoma of the frontal sinus. Only one-third of the patients affected were symptomatic at initial presentation. The 2 other common fibro-osseous tumor entities, fibrous dysplasia and ossifying fibroma, were confirmed in 12 and 6 patients, respectively. Patients with soft tissue tumor entities such as hemangioma, glomangiopericytoma, angiofibroma, and hamartoma were all symptomatic and underwent surgical resection. CONCLUSION Understanding and recognizing the spectrum of appearances of benign mesenchymal sinonasal tumors will improve patient assessment and clinical management. The pathognomonic neuroradiological signs of a particular tumor entity should be actively sought as the neuroradiological features may be the diagnostic clues. Computed tomography and magnetic resonance imaging play complementary roles in identifying the morphological details and locoregional staging of benign mesenchymal sinonasal tumors.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Service Sector > Institute of Pathology > Clinical Pathology
04 Faculty of Medicine > Service Sector > Institute of Pathology
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ear, Nose and Throat Disorders (ENT)
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology

UniBE Contributor:

Anschütz, Lukas Peter; Dettmer, Matthias; Caversaccio, Marco and Wagner, Franca


500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health








Martin Zbinden

Date Deposited:

08 Aug 2017 08:20

Last Modified:

09 Jul 2018 13:28

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