Suppression of interictal spikes during phasic rapid eye movement sleep: a quantitative stereo-electroencephalography study.

Campana, C; Zubler, Frédéric Alexis Rudolf; Gibbs, S; de Carli, F; Proserpio, P; Rubino, A; Cossu, M; Tassi, L; Schindler, Kaspar Anton; Nobili, L (2017). Suppression of interictal spikes during phasic rapid eye movement sleep: a quantitative stereo-electroencephalography study. Journal of sleep research, 26(5), pp. 606-613. Wiley-Blackwell 10.1111/jsr.12533

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Tonic and phasic rapid eye movement (REM) sleep seem to represent two different brain states exerting different effects on epileptic activity. In particular, interictal spikes are suppressed strongly during phasic REM sleep. The reason for this effect is not understood completely. A different level of synchronization in phasic and tonic REM sleep has been postulated, yet never measured directly. Here we assessed the interictal spike rate across non-REM (NREM) sleep, phasic and tonic REM sleep in nine patients affected by drug resistant focal epilepsy: five with type II focal cortical dysplasia and four with hippocampal sclerosis. Moreover, we applied different quantitative measures to evaluate the level of synchronization at the local and global scale during phasic and tonic REM sleep. We found a lower spike rate in phasic REM sleep, both within and outside the seizure onset zone. This effect seems to be independent from the histopathological substrate and from the brain region, where epileptic activity is produced (temporal versus extra-temporal). A higher level of synchronization was observed during tonic REM sleep both on a large (global) and small (local) spatial scale. Phasic REM sleep appears to be an interesting model for understanding the mechanisms of suppression of epileptic activity.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DCR Unit Sahli Building > Forschungsgruppe Neurologie
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Zubler, Frédéric Alexis Rudolf and Schindler, Kaspar Anton

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0962-1105

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Stefanie Hetzenecker

Date Deposited:

27 Jul 2017 09:24

Last Modified:

16 Jul 2018 15:25

Publisher DOI:

10.1111/jsr.12533

PubMed ID:

28401614

Uncontrolled Keywords:

epilepsy; interictal epileptiform discharges; phasic REM sleep; stereo-EEG; synchronization; tonic REM sleep

BORIS DOI:

10.7892/boris.99474

URI:

https://boris.unibe.ch/id/eprint/99474

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