Preclinical Multimodal Molecular Imaging Using 18 F-FDG PET/CT and MRI in a Phase I Study of a Knee Osteoarthritis in In Vivo Canine Model

Menendez, Maria I.; Hettlich, Bianca Felicitas; Wei, Lai; Knopp, Michael V. (2017). Preclinical Multimodal Molecular Imaging Using 18 F-FDG PET/CT and MRI in a Phase I Study of a Knee Osteoarthritis in In Vivo Canine Model. Molecular imaging, 16, p. 1536012117697443. SAGE Publications 10.1177/1536012117697443

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The aim of this study was to use a multimodal molecular imaging approach to serially assess regional metabolic changes in the knee in an in vivo anterior cruciate ligament transection (ACLT) canine model of osteoarthritis (OA). Five canine underwent ACLT in one knee and the contralateral knee served as uninjured control. Prior, 3, 6, and 12 weeks post-ACLT, the dogs underwent 18F-fluoro-d-glucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) and magnetic resonance imaging (MRI). The MRI was coregistered with the PET/CT, and 3-dimensional regions of interest (ROIs) were traced manually and maximum standardized uptake values (SUVmax) were evaluated. 18F-fluoro-d-glucose SUVmax in the ACLT knee ROIs was significantly higher compared to the uninjured contralateral knees at 3, 6, and 12 weeks. Higher 18F-FDG uptake observed in ACLT knees compared to the uninjured knees reflects greater metabolic changes in the injured knees over time. Knee 18F-FDG uptake in an in vivo ACLT canine model using combined PET/CT and MRI demonstrated to be highly sensitive in the detection of metabolic alterations in osseous and nonosteochondral structures comprising the knee joint. 18F-fluoro-d-glucose appeared to be a capable potential imaging biomarker for early human knee OA diagnosis, prognosis, and management.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV)
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Small Animal Clinic > Small Animal Clinic, Surgery
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Small Animal Clinic

UniBE Contributor:

Hettlich, Bianca Felicitas

Subjects:

500 Science > 570 Life sciences; biology

ISSN:

1536-0121

Publisher:

SAGE Publications

Language:

English

Submitter:

Bianca Felicitas Hettlich

Date Deposited:

06 Sep 2017 12:36

Last Modified:

10 Sep 2017 08:17

Publisher DOI:

10.1177/1536012117697443

PubMed ID:

28654381

BORIS DOI:

10.7892/boris.99512

URI:

https://boris.unibe.ch/id/eprint/99512

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