Herbicide safeners and glutathione metabolism

Farago, Slobodan; Brunold, Christian; Kreuz, Klaus (1994). Herbicide safeners and glutathione metabolism. Physiologia Plantarum, 91(3), pp. 537-542. Blackwell 10.1111/j.1399-3054.1994.tb02985.x

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Herbicide safeners are chemicals which protect crop plants from injury by certain herbicides, without affecting weed control efficacy of the herbicides. The protective mechanism of herbicide safeners has not yet been fully elucidated, but there is increasing evidence that safeners act by selectively enhancing herbicide detoxification in crop plants. To date, two main detoxification pathways have been related to the mode of action of herbicide safeners. The first includes oxidation and subsequent glucose conjugation, mediated by cytochrome P450-dependent monooxygenases and UDP-glucosyltransferases, respectively. This pathway appears to be important predominantly in safener protection to aryloxyphenoxypropionate and sulfonylurea herbicides. The second pathway represents the conjugation of thiocarbamate sulfoxides and chloroacetanilide herbicides with glutathione. This mechanism is accomplished by either elevating the levels of reduced glutathione or the activity of glutathione S-transferase, or both. Since glutathione has been reported to be involved in several stress situations of plants its function associated with safener-induced herbicide tolerance will be discussed in more detail in this review.

Item Type:

Journal Article (Original Article)


08 Faculty of Science > Department of Biology > Institute of Plant Sciences (IPS) > Stress Physiology (discontinued)
08 Faculty of Science > Department of Biology > Institute of Plant Sciences (IPS)

UniBE Contributor:

Brunold, Christian


500 Science > 580 Plants (Botany)








Peter Alfred von Ballmoos-Haas

Date Deposited:

04 Jul 2017 11:15

Last Modified:

15 Nov 2017 14:45

Publisher DOI:


Uncontrolled Keywords:

Environmental stress; glutathione; glutathione S-transferase; herbicide detoxification; safener; sulfate assimilation



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