Dramatic Effect of Oral CSF-1R Kinase Inhibitor on Retinal Microglia Revealed by In Vivo Scanning Laser Ophthalmoscopy

Ebneter, Andreas; Kokona, Despina; Jovanovic, Joël; Zinkernagel, Martin (2017). Dramatic Effect of Oral CSF-1R Kinase Inhibitor on Retinal Microglia Revealed by In Vivo Scanning Laser Ophthalmoscopy. Translational vision science & technology, 6(2), p. 10. Association for Research in Vision and Ophthalmology 10.1167/tvst.6.2.10

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This report provides sound evidence that the small molecule pharmaceutical PLX5622, a highly selective CSF-1R kinase inhibitor, crosses the blood-retina barrier and suppresses microglia activity. Members of this class of drug are in advanced clinical development stages and may represent a novel approach to modulate ocular inflammatory processes.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Ebneter, Andreas and Zinkernagel, Martin

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2164-2591

Publisher:

Association for Research in Vision and Ophthalmology

Language:

English

Submitter:

Andreas Ebneter

Date Deposited:

17 Aug 2017 12:47

Last Modified:

07 Mar 2018 12:46

Publisher DOI:

10.1167/tvst.6.2.10

PubMed ID:

28458957

BORIS DOI:

10.7892/boris.99595

URI:

https://boris.unibe.ch/id/eprint/99595

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