Swept-source optical coherence tomography angiography reveals vascular changes in intermediate uveitis.

Tian, Meng; Tappeiner, Christoph; Zinkernagel, Martin; Wolf, Sebastian; Munk, Marion (2019). Swept-source optical coherence tomography angiography reveals vascular changes in intermediate uveitis. Acta ophthalmologica, 97(5), e785-e791. Wiley 10.1111/aos.14024

Text Tian_et_al-2019-Acta_Ophthalmologica.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (1MB)

PURPOSE

To evaluate retinal and choroidal vascular changes in patients with intermediate uveitis with/without concomitant retinal vasculitis using wide field swept-source optical coherence tomography angiography (OCTA).

METHODS

In this study consecutive patients with intermediate uveitis ± vasculitis and healthy age-matched controls were evaluated using central 3 × 3 mm OCTA scans and montage scans. Differences among the groups as well as the association between central changes assessed by 3 × 3 scans and wide field OCTA were evaluated.

RESULTS

93 eyes of 58 patients with intermediate uveitis and 33 healthy age-matched controls were included. The presence of a cystoid macular oedema (CME) was associated with capillary non-and reduced perfusion of the superficial capillary plexus (SCP) (p = 0.03 and 0.02, respectively), and deep capillary plexus (DCP) (p = 0.02 and p ≤ 0.0001, respectively) of the 3 × 3 mm scans. The raw length, circularity and size of foveal avascular area (FAZ) significantly differed among the three groups. (p = 0.01, p = 0.045 and p = 0.004, respectively). Multivariable regression analysis revealed that the presence of epiretinal membranes (ERM) and CME rather than the disease entity contributed to the changes of FAZ size (R  = 0.15, p = 0.0003) The mean vessel density (VD) of the SCP significantly differed among the three groups (intermediate uveitis with concomitant vasculitis: 16.8 ± 3.8 mm vs intermediate uveitis only: 15.6 ± 4.4 mm versus control: 18 ± 3.5 mm , p = 0.046). Multivariable regression analysis showed that the presence of CME rather than the disease entity impacted vessel density of SCP (R  = 0.1, p = 0.016). There was no association between peripheral non- or reduced perfusion of the wide field OCTA slabs of the SCP and DCP and the VD of the 3 × 3 slabs.

CONCLUSION

Although patients with intermediate uveitis and vasculitis present with reduced central vessel density compared to healthy age-matched controls, these changes are presumably contributed to the presence of CME.

Interest & Impact

Downloads

1 since deposited on 20 Feb 2019
0 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item