Graeter, Stefanie; Simon, Hans-Uwe; von Gunten, Stephan (2020). Granulocyte death mediated by specific antibodies in intravenous immunoglobulin (IVIG). Pharmacological research, 154, p. 104168. Elsevier 10.1016/j.phrs.2019.02.007
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Simon_von Gunten_Granulocyte death mediated by specific antibodies in intravenous immunoglobulin (IVIG)..pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (530kB) | Request a copy |
Granulocytes are key effector cells of the innate immune system that cause substantial by-stander tissue damage in a broad range of inflammatory disorders. Specific antibodies with the potential to regulate granulocyte survival are present in polyclonal intravenous immunoglobulin (IVIG) preparations and may contribute to the anti-inflammatory effects of high-dose IVIG therapy. Here, we discuss idiosyncratic characteristics of antibodies to FAS and Siglecs contained in IVIG pertaining to granulocyte death regulation and highlight implications for research and clinical practice.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology |
Graduate School: |
Graduate School for Cellular and Biomedical Sciences (GCB) |
UniBE Contributor: |
Graeter, Stefanie Rebecca, Simon, Hans-Uwe, von Gunten, Stephan |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1043-6618 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Celine Joray |
Date Deposited: |
23 Apr 2019 13:21 |
Last Modified: |
02 Mar 2023 23:31 |
Publisher DOI: |
10.1016/j.phrs.2019.02.007 |
PubMed ID: |
30738127 |
Uncontrolled Keywords: |
Eosinophils FAS Granulocytes High-dose IVIG IVIG Immunomodulation Intravenous immunoglobulin Neutrophils Siglec-8 Siglec-9 |
BORIS DOI: |
10.7892/boris.127438 |
URI: |
https://boris.unibe.ch/id/eprint/127438 |
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