Li, Shuangjiang; Zhang, Wenbiao; Zhang, Yang; Li, Yongjiang; Du, Heng; Che, Guowei (2021). Systemic Inflammation Score as a Novel Prognostic Indicator for Patients Undergoing Video-Assisted Thoracoscopic Surgery Lobectomy for Non-Small-Cell Lung Cancer. Journal of investigative surgery, 34(4), pp. 428-440. Taylor & Francis 10.1080/08941939.2019.1641169
Full text not available from this repository. (Request a copy)Background: To evaluate the prognostic significance of systemic inflammation score (SIS) for patients undergoing video-assisted thoracoscopic surgery (VATS) lobectomy for non-small-cell lung cancers (NSCLCs). Methods: This retrospective cohort study was conducted on the prospectively maintained database in our institution during the study period. Preoperative SIS comprising serum albumin (sALB) and lymphocyte-to-monocyte ratio (LMR) was graded into 0, 1 and 2. Survival analysis was performed to distinguish differences in postoperative survival between three groups of SIS. Finally, multivariate Cox proportional hazards regression analyses were conducted to determine independent prognostic factors. Results: There were 390 patients with operable NSCLCs included. We applied sALB at 40 g/L and our median LMR at 3.91 as the cutoffs for modified SIS scoring criteria. Both overall survival (OS) and disease-free survival (DFS) were significantly shortened in a step-wise fashion with each 1-point increase in SIS (Log-rank p < .001). There was a significant step-wise decline in both OS and DFS rates in proportion to SIS (p < .001). No difference was found in postoperative complications between three groups of SIS. Multivariate analyses finally demonstrated that both SIS = 1 and SIS = 2 could be independent prognostic factors for unfavorable OS and DFS of NSCLCs. Conclusions: SIS can serve as a novel risk stratification tool to refine the prognostic prediction for surgical NSCLCs.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Thoracic Surgery |
Graduate School: |
Graduate School for Cellular and Biomedical Sciences (GCB) |
UniBE Contributor: |
Yang, Zhang (A) |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0894-1939 |
Publisher: |
Taylor & Francis |
Language: |
English |
Submitter: |
Thomas Michael Marti |
Date Deposited: |
27 Nov 2019 13:09 |
Last Modified: |
05 Dec 2022 15:32 |
Publisher DOI: |
10.1080/08941939.2019.1641169 |
PubMed ID: |
31304810 |
Uncontrolled Keywords: |
disease-free survival non-small-cell lung cancer overall survival systemic inflammation score video-assisted thoracoscopic surgery |
URI: |
https://boris.unibe.ch/id/eprint/135011 |
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