Bhardwaj, Rajesh

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2024

Kumar, Manjeet; Michael, Sushama; Alvarado-Valverde, Jesús; Zeke, András; Lazar, Tamas; Glavina, Juliana; Nagy-Kanta, Eszter; Donagh, Juan Mac; Kalman, Zsofia E; Pascarelli, Stefano; Palopoli, Nicolas; Dobson, László; Suarez, Carmen Florencia; Van Roey, Kim; Krystkowiak, Izabella; Griffin, Juan Esteban; Nagpal, Anurag; Bhardwaj, Rajesh; Diella, Francesca; Mészáros, Bálint; ... (2024). ELM-the Eukaryotic Linear Motif resource-2024 update. Nucleic acids research, 52(D1), D442-D455. Oxford University Press 10.1093/nar/gkad1058

Tscherrig, Dominic; Bhardwaj, Rajesh; Biner, Daniel; Dernič, Jan; Ross-Kaschitza, Daniela; Peinelt, Christine; Hediger, Matthias A; Lochner, Martin (2024). Development of chemical tools based on GSK-7975A to study store-operated calcium entry in cells. Cell calcium, 117, p. 102834. Elsevier 10.1016/j.ceca.2023.102834

2022

Sanchez-Collado, Jose; Nieto-Felipe, Joel; Jardin, Isaac; Bhardwaj, Rajesh; Berna-Erro, Alejandro; Salido, Gines M; Smani, Tarik; Hediger, Matthias A; Lopez, Jose J; Rosado, Juan A (2022). Store-Operated Calcium Entry in Breast Cancer Cells Is Insensitive to Orai1 and STIM1 N-Linked Glycosylation. Cancers, 15(1) MDPI AG 10.3390/cancers15010203

Augustynek, Bartlomiej; Gyimesi, Gergely; Dernič, Jan; Sallinger, Matthias; Albano, Giuseppe; Klesse, Gabriel J; Kandasamy, Palanivel; Grabmayr, Herwig; Frischauf, Irene; Fuster, Daniel G; Peinelt, Christine; Hediger, Matthias A; Bhardwaj, Rajesh (2022). Discovery of novel gating checkpoints in the Orai1 calcium channel by systematic analysis of constitutively active mutants of its paralogs and orthologs. Cell calcium, 105, p. 102616. Elsevier 10.1016/j.ceca.2022.102616

Verouti, Sophia N; Pujol-Giménez, Jonai; Bermudez-Lekerika, Paola; Scherler, Laeticia; Bhardwaj, Rajesh; Thomas, Aurélien; Lenglet, Sébastien; Siegrist, Mark; Hofstetter, Willy; Fuster, Daniel G; Hediger, Matthias A; Escher, Geneviève; Vogt, Bruno (2022). The Allelic Variant A391T of Metal Ion Transporter ZIP8 (SLC39A8) Leads to Hypotension and Enhanced Insulin Resistance. Frontiers in physiology, 13, p. 912277. Frontiers Research Foundation 10.3389/fphys.2022.912277

2021

Pujol-Giménez, Jonai; Poirier, Marion; Bühlmann, Sven; Schuppisser, Céline; Bhardwaj, Rajesh; Awale, Mahendra; Visini, Ricardo; Javor, Sacha; Hediger, Matthias; Reymond, Jean-Louis (2021). Inhibitors of Human Divalent Metal Transporters DMT1 (SLC11A2) and ZIP8 (SLC39A8) from a GDB-17 Fragment Library. ChemMedChem, 16(21), pp. 3306-3314. Wiley-VCH 10.1002/cmdc.202100467

Kandasamy, Palanivel; Zlobec, Inti; Nydegger, Damian T.; Pujol-Gimenez, Jonai; Bhardwaj, Rajesh; Shirasawa, Senji; Tsunoda, Toshiyuki; Hediger, Matthias A. (2021). Oncogenic KRAS mutations enhance amino acid uptake by colorectal cancer cells via the hippo signaling effector YAP1. Molecular oncology, 15(10), pp. 2782-2800. Wiley 10.1002/1878-0261.12999

Kar, Pulak; Lin, Yu-Ping; Bhardwaj, Rajesh; Tucker, Charles J; Bird, Gary S; Hediger, Matthias A.; Monico, Carina; Amin, Nader; Parekh, Anant B (2021). The N terminus of Orai1 couples to the AKAP79 signaling complex to drive NFAT1 activation by local Ca2+ entry. Proceedings of the National Academy of Sciences of the United States of America - PNAS, 118(19) National Academy of Sciences NAS 10.1073/pnas.2012908118

Anderegg, Manuel A.; Albano, Giuseppe; Hanke, Daniela; Deisl, Christine; Uehlinger, Dominik E.; Brandt, Simone; Bhardwaj, Rajesh; Hediger, Matthias A.; Fuster, Daniel G. (2021). The sodium/proton exchanger NHA2 regulates blood pressure through a WNK4-NCC dependent pathway in the kidney. Kidney international, 99(2), pp. 350-363. Elsevier 10.1016/j.kint.2020.08.023

Augustynek, Bartlomiej; Gyimesi, Gergely; Dernic, Jan; Sallinger, Matthias; Albano, Giuseppe; Klesse, Gabriel J.; Kandasamy, Palanivel; Grabmayr, Herwig; Frischauf, Irene; Fuster, Daniel G.; Peinelt, Christine; Hediger, Matthias A.; Bhardwaj, Rajesh (2021). Dissecting gating mechanisms of Orai calcium channel paralogs using constitutively active Orai mutants that mimic STIM1-gated state (In Press) (bioRxiv). Cold Spring Harbor Laboratory 10.1101/2021.10.26.465861

2020

Bhardwaj, Rajesh; Lindinger, Sonja; Neuberger, Arthur; Nadezhdin, Kirill D.; Singh, Appu K.; R. Cunha, Micael; Derler, Isabella; Gyimesi, Gergely; Reymond, Jean-Louis; Hediger, Matthias A.; Romanin, Christoph; Sobolevsky, Alexander I. (2020). Inactivation-mimicking block of the epithelial calcium channel TRPV6. Science Advances, 6(48), eabe1508. American Association for the Advancement of Science 10.1126/sciadv.abe1508

Gibhardt, Christine Silvia; Cappello, Sabrina; Bhardwaj, Rajesh; Schober, Romana; Kirsch, Sonja Agnes; Bonilla Del Rio, Zuriñe; Gahbauer, Stefan; Bochicchio, Anna; Sumanska, Magdalena; Ickes, Christian; Stejerean-Todoran, Ioana; Mitkovski, Miso; Alansary, Dalia; Zhang, Xin; Revazian, Aram; Fahrner, Marc; Lunz, Victoria; Frischauf, Irene; Luo, Ting; Ezerina, Daria; ... (2020). Oxidative Stress-Induced STIM2 Cysteine Modifications Suppress Store-Operated Calcium Entry. Cell reports, 33(3), p. 108292. Cell Press 10.1016/j.celrep.2020.108292

Schild, Achille; Bhardwaj, Rajesh; Wenger, Nicolas; Tscherrig, Dominic; Kandasamy, Palanivel; Dernič, Jan; Baur, Roland; Peinelt, Christine; Hediger, Matthias A.; Lochner, Martin (2020). Synthesis and Pharmacological Characterization of 2-Aminoethyl Diphenylborinate (2-APB) Derivatives for Inhibition of Store-Operated Calcium Entry (SOCE) in MDA-MB-231 Breast Cancer Cells. International journal of molecular sciences, 21(16) MDPI 10.3390/ijms21165604

Rodrigues Cunha, Micael; Bhardwaj, Rajesh; Carrel, Aline Lucie; Lindinger, Sonja; Romanin, Christoph; Parise-Filho, Roberto; Hediger, Matthias A.; Reymond, Jean-Louis (2020). Natural product inspired optimization of a selective TRPV6 calcium channel inhibitor. RSC Medicinal Chemistry, 11(9), pp. 1032-1040. Royal Society of Chemistry 10.1039/D0MD00145G

Bhardwaj, Rajesh; Augustynek, Bartlomiej S.; Ercan-Herbst, Ebru; Kandasamy, Palanivel; Seedorf, Matthias; Peinelt, Christine; Hediger, Matthias A. (2020). Ca2+/Calmodulin Binding to STIM1 Hydrophobic Residues Facilitates Slow Ca2+-Dependent Inactivation of the Orai1 Channel. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 54(2), pp. 252-270. 10.33594/000000218

2019

R. Cunha, Micael; Bhardwaj, Rajesh; Lindinger, Sonja; Butorac, Carmen; Romanin, Christoph; Hediger, Matthias; Reymond, Jean-Louis (2019). Photoswitchable Inhibitor of the Calcium Channel TRPV6. ACS medicinal chemistry letters, 10(9), pp. 1341-1345. American Chemical Society 10.1021/acsmedchemlett.9b00298

Schild, Achille; Bhardwaj, Rajesh; Hediger, Matthias; Lochner, Martin (6 September 2019). Diverse effects of halogenated 2-aminoethoxydiphenyl borate derivatives on store-operated calcium entry in breast cancer cells. CHIMIA, 73(7/8). Schweizerische Chemische Gesellschaft

Tscherrig, Dominic; Bhardwaj, Rajesh; Dernic, Jan; Hediger, Matthias; Lochner, Martin (6 September 2019). Synthesis of functionalized probes based on GSK7975A to study SOCE. CHIMIA, 73(7/8). Schweizerische Chemische Gesellschaft

Butorac, Carmen; Muik, Martin; Derler, Isabella; Stadlbauer, Michael; Lunz, Victoria; Krizova, Adéla; Lindinger, Sonja; Schober, Romana; Frischauf, Irene; Bhardwaj, Rajesh; Hediger, Matthias A.; Groschner, Klaus; Romanin, Christoph (2019). A novel STIM1-Orai1 gating interface essential for CRAC channel activation. Cell calcium, 79, pp. 57-67. Elsevier 10.1016/j.ceca.2019.02.009

Bulla, M.; Gyimesi, Gergely; Kim, JH.; Bhardwaj, Rajesh; Hediger, Matthias; Frieden, M.; Demaurex, N. (2019). ORAI1 channel gating and selectivity is differentially altered by natural mutations in the first or third transmembrane domain. Journal of physiology, 597(2), pp. 561-582. Wiley-Blackwell 10.1113/JP277079

2018

Schild, Achille; Bhardwaj, Rajesh; Hediger, Matthias; Lochner, Martin (7 September 2018). Study of 2-Aminoethoxy Borate (2-APB) Analogues in MDA-MB-231 and MCF-7 Cells towards Orai Isoform-specific Modulation of Store-operated Calcium Entry (SOCE). CHIMIA, 72(7/8). Schweizerische Chemische Gesellschaft

Tscherrig, Dominic; Bhardwaj, Rajesh; Hediger, Matthias; Lochner, Martin (7 September 2018). Synthesis of Functionalised Probes Based on GSK7975A to Study SOCE. CHIMIA, 72(7/8). Schweizerische Chemische Gesellschaft

2017

Schild, Achille; Bhardwaj, Rajesh; Hediger, Matthias; Lochner, Martin (21 August 2017). Diaryl Boronic Acid Modulate Store-operated Calcium Entry (SOCE). CHIMIA, 71(7/8). Schweizerische Chemische Gesellschaft

Tscherrig, Dominic; Bhardwaj, Rajesh; Hediger, Matthias; Lochner, Martin (21 August 2017). Synthesis of Novel Probes based on GSK7975A to study SOCE. CHIMIA, 71(7/8). Schweizerische Chemische Gesellschaft

2016

Schild, Achille; Tscherrig, Dominic Armin; Wenger, Nicolas; Rajesh, Rajesh; Lüscher, Benjamin; Hediger, Matthias; Lochner, Martin (August 2016). Design, synthesis and pharmacological characterization of novel store-operated calcium channel (SOCE) modulators. CHIMIA, 70(7/8), MC125. Schweizerische Chemische Gesellschaft

Rajesh, Rajesh; Hediger, Matthias; Demaurex, Nicolas (2016). Redox modulation of STIM-ORAI signaling. Cell calcium, 60(2), pp. 142-152. Elsevier 10.1016/j.ceca.2016.03.006

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