Christen, Stephan

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Brugger, Silvio; Troxler, Lukas; Rüfenacht, Susanne; Frey, Pascal Marcel; Morand, Brigitte; Geyer, Rudolf; Mühlemann, Kathrin; Höck, Stefan; Thormann, Wolfgang; Furrer, Julien; Christen, Stephan; Hilty, Markus (2016). Polysaccharide capsule composition of pneumococcal serotype 19A subtypes: Unaltered among subtypes and independent of the nutritional environment. Infection and immunity, 84(11), pp. 3152-3160. American Society for Microbiology 10.1128/IAI.00474-16

Jayadev Kamat, Pranitha; Vandenberghe, Stijn; Christen, Stephan; Bongoni, Anjan; Meier, Bernhard; Rieben, Robert; Khattab, Ahmed Aziz (2016). Dexrazoxane Shows No Protective Effect in the Acute Phase of Reperfusion during Myocardial Infarction in Pigs. PLoS ONE, 11(12), e0168541. Public Library of Science 10.1371/journal.pone.0168541


Tveden-Nyborg, Pernille; Vogt, Lucile; Schjoldager, Janne G.; Jeannet, Natalie; Hasselholt, Stine; Paidi, Maya D.; Lykkesfeldt, Jens; Christen, Stephan (2012). Maternal vitamin C deficiency during pregnancy persistently impairs hippocampal neurogenesis in offspring of guinea pigs. PLoS ONE, 7(10), e48488. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0048488

Autheman, Delphine; Sheldon, R Ann; Chaudhuri, Nondini; von Arx, Sebastian; Siegenthaler, Corinne; Ferriero, Donna M; Christen, Stephan (2012). Glutathione peroxidase overexpression causes aberrant ERK activation in neonatal mouse cortex after hypoxic preconditioning. Pediatric research, 72(6), pp. 568-75. New York, N.Y.: Nature Publishing Group 10.1038/pr.2012.124


Ortmann, Jana; Veit, Martha; Zingg, Sandra; Di Santo, Stefano; Traupe, Tobias; Yang, Zijiang; Völzmann, Jan; Dubey, Raghvendra K; Christen, Stephan; Baumgartner, Iris (2011). Estrogen receptor- but not - or GPER inhibits high glucose-induced human VSMC proliferation: potential role of ROS and ERK. Journal of clinical endocrinology and metabolism, 96(1), pp. 220-8. Chevy Chase, Md.: Endocrine Society 10.1210/jc.2010-0943

Sury, Matthias D.; Vorlet-Fawer, Lorianne; Agarinis, Claudia; Yousefi, Shida; Grandgirard, Denis; Leib, Stephen L.; Christen, Stephan (2011). Restoration of Akt activity by the bisperoxovanadium compound bpV(pic) attenuates hippocampal apoptosis in experimental neonatal pneumococcal meningitis. Neurobiology of disease, 41(1), pp. 201-208. Amsterdam: Elsevier 10.1016/j.nbd.2010.09.007


Bellac, Caroline L.; Coimbra, Roney S.; Christen, Stephan; Leib, Stephen L. (2010). Inhibition of the kynurenine-NAD+ pathway leads to energy failure and exacerbates apoptosis in pneumococcal meningitis. Journal of neuropathology and experimental neurology, 69(11), pp. 1096-1104. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1097/NEN.0b013e3181f7e7e9


Sheldon, R Ann; Christen, Stephan; Ferriero, Donna M (2008). Genetic and pharmacologic manipulation of oxidative stress after neonatal hypoxia-ischemia. International journal of developmental neuroscience, 26(1), pp. 87-92. Kidlington, UK: Elsevier Science 10.1016/j.ijdevneu.2007.08.010

Sury, Matthias D.; Agarinis, Claudia; Widmer, Hans-Rudolf; Leib, Stephen L.; Christen, Stephan (2008). JNK is activated but does not mediate hippocampal neuronal apoptosis in experimental neonatal pneumococcal meningitis. Neurobiology of disease, 32(1), pp. 142-150. Amsterdam: Elsevier 10.1016/J.nbd.2008.07.006


Ren, Hao; Leib, Stephen L.; Ferriero, Donna M; Täuber, Martin G.; Christen, Stephan (2007). Induction of haem oxygenase-1 causes cortical non-haem iron increase in experimental pneumococcal meningitis: evidence that concomitant ferritin up-regulation prevents iron-induced oxidative damage. Journal of neurochemistry, 100(2), pp. 532-544. Oxford: Wiley-Blackwell 10.1111/j.1471-4159.2006.04230.x

Christen, Stephan; Cattin, Isabelle; Knight, Iona; Winyard, Paul G; Blum, Jürg W; Elsasser, Theodore H (2007). Plasma S-nitrosothiol status in neonatal calves: ontogenetic associations with tissue-specific S-nitrosylation and nitric oxide synthase. Experimental biology and medicine, 232(2), pp. 309-22. Maywood, N.J.: Society for Experimental Biology & Medicine

Lykkesfeldt, Jens; Trueba, Gilberto Perez; Poulsen, Henrik E; Christen, Stephan (2007). Vitamin C deficiency in weanling guinea pigs: differential expression of oxidative stress and DNA repair in liver and brain. British journal of nutrition, 98(6), pp. 1116-9. Cambridge: Cambridge University Press 10.1017/S0007114507787457

Lykkesfeldt, Jens; Morgan, Evan; Christen, Stephan; Skovgaard, Lene Theil; Moos, Torben (2007). Oxidative stress and damage in liver, but not in brain, of Fischer 344 rats subjected to dietary iron supplementation with lipid-soluble [(3,5,5-trimethylhexanoyl)ferrocene]. Journal of biochemical and molecular toxicology, 21(3), pp. 145-55. New York, N.Y.: Wiley & Sons 10.1002/jbt.20170

Sheldon, R Ann; Aminoff, Alexandra; Lee, Christina L; Christen, Stephan; Ferriero, Donna M (2007). Hypoxic preconditioning reverses protection after neonatal hypoxia-ischemia in glutathione peroxidase transgenic murine brain. Pediatric research, 61(6), pp. 666-70. New York, N.Y.: Nature Publishing Group 10.1203/pdr.0b013e318053664c

Reiter, Elke; Jiang, Qing; Christen, Stephan (2007). Anti-inflammatory properties of alpha- and gamma-tocopherol. Molecular aspects of medicine, 28(5-6), pp. 668-91. Amsterdam: Elsevier 10.1016/j.mam.2007.01.003


Sury, Matthias D; Frese-Schaper, Manuela; Mühlemann, Miranda K; Schulthess, Fabienne T; Blasig, Ingolf E; Täuber, Martin G; Shaw, Sidney G; Christen, Stephan (2006). Evidence that N-acetylcysteine inhibits TNF-alpha-induced cerebrovascular endothelin-1 upregulation via inhibition of mitogen- and stress-activated protein kinase. Free radical biology & medicine, 41(9), pp. 1372-83. San Diego, Calif.: Elsevier 10.1016/j.freeradbiomed.2006.07.016

Bellac, Caroline L.; Coimbra, Roney S.; Christen, Stephan; Leib, Stephen L. (2006). Pneumococcal meningitis causes accumulation of neurotoxic kynurenine metabolites in brain regions prone to injury. Neurobiology of disease, 24(2), pp. 395-402. Amsterdam: Elsevier 10.1016/j.nbd.2006.07.014


Schmitt, B; Finckh, B; Christen, S; Lykkesfeldt, J; Schmid, ER; Bauersfeld, U; Critelli, H; Hajnal, BL; Gessler, P; Molinari, L (2005). Electroencephalographic changes after pediatric cardiac surgery with cardiopulmonary bypass: is slow wave activity unfavorable? Pediatric research, 58(4), pp. 771-8. New York, N.Y.: Nature Publishing Group 10.1203/01.PDR.0000180554.16652.4E

Christen, S; Finckh, B; Lykkesfeldt, J; Gessler, P; Frese-Schaper, M; Nielsen, P; Schmid, ER; Schmitt, B (2005). Oxidative stress precedes peak systemic inflammatory response in pediatric patients undergoing cardiopulmonary bypass operation. Free radical biology & medicine, 38(10), pp. 1323-32. San Diego, Calif.: Elsevier 10.1016/j.freeradbiomed.2005.01.016


Böttcher, T; Ren, H; Goiny, M; Gerber, J; Lykkesfeldt, J; Kuhnt, U; Lotz, M; Bunkowski, S; Werner, C; Schau, I; Spreer, A; Christen, S; Nau, R (2004). Clindamycin is neuroprotective in experimental Streptococcus pneumoniae meningitis compared with ceftriaxone. Journal of neurochemistry, 91(6), pp. 1450-60. Oxford: Wiley-Blackwell 10.1111/j.1471-4159.2004.02837.x

Jiang, X; Mu, D; Manabat, C; Koshy, AA; Christen, S; Täuber, MG; Vexler, ZS; Ferriero, DM (2004). Differential vulnerability of immature murine neurons to oxygen-glucose deprivation. Experimental neurology, 190(1), pp. 224-32. San Diego, Calif.: Elsevier 10.1016/j.expneurol.2004.07.010

Sheldon, RA; Jiang, X; Francisco, C; Christen, S; Vexler, ZS; Täuber, MG; Ferriero, DM (2004). Manipulation of antioxidant pathways in neonatal murine brain. Pediatric research, 56(4), pp. 656-62. New York, N.Y.: Nature Publishing Group 10.1203/01.PDR.0000139413.27864.50


Schaper, Manuela; Leib, Stephen; Meli, Damian N; Brandes, Ralf P; Täuber, Martin G.; Christen, Stephan (2003). Differential effect of p47phox and gp91phox deficiency on the course of Pneumococcal Meningitis. Infection and immunity, 71(7), pp. 4087-4092. American Society for Microbiology 10.1128/IAI.71.7.4087-4092.2003

Ghielmetti, Marco; Ren, Hao; Leib, Stephen; Täuber, Martin G.; Christen, Stephan (2003). Impaired cortical energy metabolism but not major antioxidant defenses in experimental bacterial meningitis. Brain research, 976(2), pp. 139-148. Elsevier 10.1016/S0006-8993(03)02557-5

Meli, Damian N.; Christen, Stephan; Leib, Stephen L. (2003). Matrix metalloproteinase-9 in pneumococcal meningitis: activation via an oxidative pathway. Journal of infectious diseases, 187(9), pp. 1411-1415. Cary, N.C.: The University of Chicago Press 10.1086/374644

Vexler, ZS; Wong, A; Francisco, C; Manabat, C; Christen, S; Täuber, M; Ferriero, DM; Gregory, G (2003). Fructose-1,6-bisphosphate preserves intracellular glutathione and protects cortical neurons against oxidative stress. Brain research, 960(1-2), pp. 90-8. Amsterdam: Elsevier 10.1016/S0006-8993(02)03777-0


Jiang, Q; Lykkesfeldt, J; Shigenaga, MK; Shigeno, ET; Christen, S; Ames, BN (2002). Gamma-tocopherol supplementation inhibits protein nitration and ascorbate oxidation in rats with inflammation. Free radical biology & medicine, 33(11), pp. 1534-42. San Diego, Calif.: Elsevier 10.1016/S0891-5849(02)01091-2

Christen, S; Jiang, Q; Shigenaga, MK; Ames, BN (2002). Analysis of plasma tocopherols alpha, gamma, and 5-nitro-gamma in rats with inflammation by HPLC coulometric detection. Journal of lipid research, 43(11), pp. 1978-85. Bethesda, Md.: American Society for Biochemistry and Molecular Biology ASBMB 10.1194/jlr.D200023-JLR200

Schaper, Manuela; Gergely, Suzanne; Lykkesfeldt, Jens; Zbären, Jakob; Leib, Stephen L.; Täuber, Martin G.; Christen, Stephan (2002). Cerebral vasculature is the major target of oxidative protein alterations in bacterial meningitis. Journal of neuropathology and experimental neurology, 61(7), pp. 605-13. Hagerstown, Md.: Lippincott Williams & Wilkins

Meli, Damian N.; Christen, Stephan; Leib, Stephen L.; Täuber, Martin G. (2002). Current concepts in the pathogenesis of meningitis caused by Streptococcus pneumoniae. Current opinion in infectious diseases, 15(3), pp. 253-357. Hagerstown, Md.: Wolters Kluwer Lippincott Williams & Wilkins 10.1097/00001432-200206000-00007

Pfister, H.; Remer, K. A.; Brcic, Marija; Fatzer, R.; Christen, Stephan; Leib, Stephen L.; Jungi, Thomas W. (2002). Inducible nitric oxide synthase and nitrotyrosine in listeric encephalitis: a cross-species study in ruminants. Veterinary pathology, 39(2), pp. 190-199. Middleton, Wis.: American College of Veterinary Pathologists 10.1354/vp.39-2-190


Girault, I; Karu, AE; Schaper, M; Barcellos-Hoff, MH; Hagen, T; Vogel, DS; Ames, BN; Christen, S; Shigenaga, MK (2001). Immunodetection of 3-nitrotyrosine in the liver of zymosan-treated rats with a new monoclonal antibody: comparison to analysis by HPLC. Free radical biology & medicine, 31(11), pp. 1375-87. San Diego, Calif.: Elsevier 10.1016/S0891-5849(01)00712-2

Jiang, Q; Christen, S; Shigenaga, MK; Ames, BN (2001). gamma-tocopherol, the major form of vitamin E in the US diet, deserves more attention. American journal of clinical nutrition, 74(6), pp. 714-22. Bethesda, Md.: American Society for Nutrition, Inc. 10.1093/ajcn/74.6.714

Christen, Stephan; Schaper, Manuela; Lykkesfeldt, Jens; Siegenthaler, Corinne; Bifrare, Yoeng-Delphine; Banic, Staša; Leib, Stephen L.; Täuber, Martin G. (2001). Oxidative stress in brain during experimental bacterial meningitis: differential effects of alpha-phenyl-tert-butyl nitrone and N-acetylcysteine treatment. Free radical biology & medicine, 31(6), pp. 754-762. San Diego, Calif.: Elsevier 10.1016/S0891-5849(01)00642-6

Christen, Stephan; Bifrare, Yeong-Delphine; Siegenthaler, Corinne; Leib, Stephen L.; Täuber, Martin G. (2001). Marked elevation in cortical urate and xanthine oxidoreductase activity in experimental bacterial meningitis. Brain research, 900(2), pp. 244-251. Amsterdam: Elsevier 10.1016/S0006-8993(01)02311-3


Pfister, LA; Tureen, JH; Shaw, S; Christen, S; Ferriero, DM; Täuber, MG; Leib, Stephen L. (2000). Endothelin inhibition improves cerebral blood flow and is neuroprotective in pneumococcal meningitis. Annals of neurology, 47(3), pp. 329-335. Hoboken, N.J.: Wiley-Blackwell 10.1002/1531-8249(200003)47:3<329::AID-ANA8>3.3.CO;2-I

Lykkesfeldt, J; Christen, S; Wallock, LM; Chang, HH; Jacob, RA; Ames, BN (2000). Ascorbate is depleted by smoking and repleted by moderate supplementation: a study in male smokers and nonsmokers with matched dietary antioxidant intakes. American journal of clinical nutrition, 71(2), pp. 530-6. Bethesda, Md.: American Society for Nutrition, Inc.


Christen, S; Woodall, AA; Shigenaga, MK; Southwell-Keely, PT; Duncan, MW; Ames, BN (1997). gamma-tocopherol traps mutagenic electrophiles such as NO(X) and complements alpha-tocopherol: physiological implications. Proceedings of the National Academy of Sciences of the United States of America - PNAS, 94(7), pp. 3217-22. Washington, D.C.: National Academy of Sciences NAS 10.1073/pnas.94.7.3217

Shigenaga, MK; Lee, HH; Blount, BC; Christen, S; Shigeno, ET; Yip, H; Ames, BN (1997). Inflammation and NO(X)-induced nitration: assay for 3-nitrotyrosine by HPLC with electrochemical detection. Proceedings of the National Academy of Sciences of the United States of America - PNAS, 94(7), pp. 3211-6. Washington, D.C.: National Academy of Sciences NAS 10.1073/pnas.94.7.3211


Christen, S; Gee, P; Ames, BN (1996). Mutagenicity of nitric oxide in base pair-specific Salmonella tester strains: TA7000 series. Methods in enzymology, 269(269), pp. 267-278. New York, N.Y.: Academic Press


Christen, S; Thomas, SR; Garner, B; Stocker, R (1994). Inhibition by interferon-gamma of human mononuclear cell-mediated low density lipoprotein oxidation. Participation of tryptophan metabolism along the kynurenine pathway. Journal of clinical investigation, 93(5), pp. 2149-58. Ann Arbor, Mich.: American Society for Clinical Investigation 10.1172/JCI117211


Christen, S; Southwell-Keely, PT; Stocker, R (1992). Oxidation of 3-hydroxyanthranilic acid to the phenoxazinone cinnabarinic acid by peroxyl radicals and by compound I of peroxidases or catalase. Biochemistry, 31(34), pp. 8090-7. Washington, D.C.: American Chemical Society 10.1021/bi00149a045

Christen, S; Stocker, R (1992). Simultaneous determination of 3-hydroxyanthranilic and cinnabarinic acid by high-performance liquid chromatography with photometric or electrochemical detection. Analytical biochemistry, 200(2), pp. 273-9. San Diego, Calif.: Elsevier 10.1016/0003-2697(92)90465-J

Buffinton, GD; Christen, S; Peterhans, E; Stocker, R (1992). Oxidative stress in lungs of mice infected with influenza A virus. Free radical research communications, 16(2), pp. 99-110. London: Harwood Academic Publ. 10.3109/10715769209049163


Christen, S; Peterhans, E; Stocker, R (1990). Antioxidant activities of some tryptophan metabolites: possible implication for inflammatory diseases. Proceedings of the National Academy of Sciences of the United States of America - PNAS, 87(7), pp. 2506-10. Washington, D.C.: National Academy of Sciences NAS 10.1073/pnas.87.7.2506

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