Eggel, Alexander

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2021

Engeroff, Paul; Plattner, Kevin; Storni, Federico; Storni, Federico; Thoms, Franziska; Frias Boligan, Kayluz; Mürner, Lukas; Eggel, Alexander; von Gunten, Stephan; Bachmann, Martin F.; Vogel, Monique (2021). Glycan-specific IgG anti-IgE autoantibodies are protective against allergic anaphylaxis in a murine model. Journal of allergy and clinical immunology, 147(4), pp. 1430-1441. Elsevier 10.1016/j.jaci.2020.11.031

Brigger, D.; Horn, M. P.; Pennington, L. F.; Powell, A. E.; Siegrist, D.; Weber, B.; Engler, O.; Piezzi, V.; Damonti, L.; Iseli, P.; Hauser, C.; Froehlich, T. K.; Villiger, P. M.; Bachmann, Martin F.; Leib, S. L.; Bittel, P.; Fiedler, M.; Largiadèr, C.; Marschall, J.; Stalder, H.; ... (2021). Accuracy of serological testing for SARS-CoV-2 antibodies: first results of a large mixed-method evaluation study. Allergy, 76(3), pp. 853-865. Wiley 10.1111/all.14608

2020

Brigger, Daniel; Riether, Carsten; van Brummelen, Robin; Mosher, Kira I; Shiu, Alicia; Ding, Zhaoqing; Zbären, Noemi; Gasser, Pascal; Guntern, Pascal; Yousef, Hanadie; Castellano, Joseph M; Storni, Federico; Graff-Radford, Neill; Britschgi, Markus; Grandgirard, Denis; Hinterbrandner, Magdalena; Siegrist, Mark; Moullan, Norman; Hofstetter, Wilhelm; Leib, Stephen L.; ... (2020). Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitness in old age. Nature metabolism, 2(8), pp. 688-702. Springer Nature 10.1038/s42255-020-0228-3

Guntern, Pascal Martin; Eggel, Alexander (2020). Past, present, and future of anti-IgE biologics. Allergy, 75(10), pp. 2491-2502. Wiley 10.1111/all.14308

Delgado, Sharon Jiménez; Dehmel, Susann; Twisterling, Elaine; Wichmann, Judy; Jonigk, Danny; Warnecke, Gregor; Braubach, Peter; Fieguth, Hans-Gerd; Wilkens, Ludwig; Dahlmann, Franziska; Kaup, Franz-Josef; Eggel, Alexander; Knauf, Sascha; Sewald, Katherina; Braun, Armin (2020). Disruptive anti-IgE inhibitors prevent mast cell-dependent early airway response in viable atopic lung tissue. Journal of allergy and clinical immunology, 145(2), 719-722.e1. Elsevier 10.1016/j.jaci.2019.11.002

Gasser, Pascal; Tarchevskaya, Svetlana S; Guntern, Pascal Martin; Brigger, Daniel; Ruppli, Rahel; Zbären, Noemi; Kleinboelting, Silke; Heusser, Christoph; Jardetzky, Theodore S; Eggel, Alexander (2020). The mechanistic and functional profile of the therapeutic anti-IgE antibody ligelizumab differs from omalizumab. Nature Communications, 11(1), p. 165. Springer Nature 10.1038/s41467-019-13815-w

2018

Boyman, Onur; Eggel, Alexander; Noti, Mario (2018). Editorial overview: Allergy and hypersensitivity: Emerging concepts in allergy and type 2 immunity. Current opinion in immunology, 54, iii-v. Elsevier 10.1016/j.coi.2018.10.002

Gasser, Pascal; Eggel, Alexander (2018). Targeting IgE in allergic disease. Current opinion in immunology, 54, pp. 86-92. Elsevier 10.1016/j.coi.2018.05.015

Zellweger, Fabian; Buschor, Patrick; Hobi, Gabriel; Brigger, Daniel; Dahinden, Clemens A.; Villiger, Peter; Eggel, Alexander (2018). IL-3 but not monomeric IgE regulates FcεRI levels and cell survival in primary human basophils. Cell death & disease, 9(5), p. 510. Nature Publishing Group 10.1038/s41419-018-0526-9

2017

Zellweger, F.; Gasser, P.; Brigger, Daniel; Buschor, P.; Vogel, Monique; Eggel, Alexander (2017). A novel bispecific DARPin targeting FcγRIIB and FcεRI-bound IgE inhibits allergic responses. Allergy, 72(8), pp. 1174-1183. Wiley-Blackwell 10.1111/all.13109

2016

Zellweger, Fabian; Eggel, Alexander (2016). IgE-associated allergic disorders: recent advances in etiology, diagnosis, and treatment. Allergy, 71(12), pp. 1652-1661. Wiley-Blackwell 10.1111/all.13059

Pennington, Luke F; Tarchevskaya, Svetlana; Brigger, Daniel; Sathiyamoorthy, Karthik; Graham, Michelle T; Nadeau, Kari Christine; Eggel, Alexander; Jardetzky, Theodore S (2016). Structural basis of omalizumab therapy and omalizumab-mediated IgE exchange. Nature communications, 7(11610), p. 11610. Nature Publishing Group 10.1038/ncomms11610

2015

Smith, Lucas K; He, Yingbo; Park, Jeong-Soo; Bieri, Gregor; Snethlage, Cedric E; Lin, Karin; Gontier, Geraldine; Wabl, Rafael; Plambeck, Kristopher E; Udeochu, Joe; Wheatley, Elizabeth G; Bouchard, Jill; Eggel, Alexander; Narasimha, Ramya; Grant, Jacqueline L; Luo, Jian; Wyss-Coray, Tony; Villeda, Saul A (2015). β2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis. Nature medicine, 21(8), pp. 932-937. Nature Publishing Group 10.1038/nm.3898

2014

Morshed, Md. Mahbubul; Hlushchuk, Ruslan; Simon, Dagmar; Walls, Andrew F.; Obata-Ninomiya, Kazushige; Karasuyama, Hajime; Djonov, Valentin; Eggel, Alexander; Kaufmann, Thomas; Simon, Hans-Uwe; Yousefi, Shida (2014). NADPH oxidase-independent formation of extracellular DNA traps by basophils. Journal of immunology, 192(11), pp. 5314-5323. American Association of Immunologists 10.4049/jimmunol.1303418

2013

Hagmann, Björn; Odermatt, Andrea; Eggel, Alexander; Dahinden, Clemens A.; Fux, Michaela (22 August 2013). Interferon-α antagonizes IL-3-mediated immunoregulatory functions of human basophils (Unpublished). In: 15th ICI (International Congress of Immunology). Milan, Italy.

Hagmann, Björn; Odermatt, Andrea; Eggel, Alexander; Dahinden, Clemens A.; Fux, Michaela (3 April 2013). Co-activation of JAK/STAT and p38 MAPK pathways by type I interferon enhances apoptosis in human basophils (Unpublished). In: 25th Meeting of the Swiss Immunology PhD Students. Wolfsberg. 03.-05.04.2013.

2012

Kim, Beomkyu; Eggel, Alexander; Tarchevskaya, Svetlana S; Vogel, Monique; Prinz, Heino; Jardetzky, Theodore S (2012). Accelerated disassembly of IgE-receptor complexes by a disruptive macromolecular inhibitor. Nature, 491(7425), pp. 613-7. London: Macmillan Journals Ltd. 10.1038/nature11546

Kim, Beomkyu; Tarchevskaya, Svetlana S; Eggel, Alexander; Vogel, Monique; Jardetzky, Theodore S (2012). A time-resolved fluorescence resonance energy transfer assay suitable for high-throughput screening for inhibitors of immunoglobulin E-receptor interactions. Analytical biochemistry, 431(2), pp. 84-9. San Diego, Calif.: Elsevier 10.1016/j.ab.2012.09.010

Wurzburg, Beth A; Kim, Beomkyu; Tarchevskaya, Svetlana S; Eggel, Alexander; Vogel, Monique; Jardetzky, Theodore S (2012). An engineered disulfide bond reversibly traps the IgE-Fc3-4 in a closed, nonreceptor binding conformation. Journal of biological chemistry, 287(43), pp. 36251-7. Bethesda, Md.: American Society for Biochemistry and Molecular Biology 10.1074/jbc.M112.407502

2011

Eggel, A; Buschor, P; Baumann, M J; Amstutz, P; Stadler, B M; Vogel, M (2011). Inhibition of ongoing allergic reactions using a novel anti-IgE DARPin-Fc fusion protein. Allergy, 66(7), pp. 961-8. Oxford: Wiley-Blackwell 10.1111/j.1398-9995.2011.02546.x

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