Gertsch, Jürg

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2018

Zákány, Nóra; Oláh, Attila; Markovics, Arnold; Takács, Erika; Aranyász, Andrea; Nicolussi, Simon; Piscitelli, Fabiana; Allarà, Marco; Pór, Ágnes; Kovács, Ilona; Zouboulis, Christos C; Gertsch, Jürg; Di Marzo, Vincenzo; Bíró, Tamás; Szabó, Tamás (2018). Endocannabinoid Tone Regulates Human Sebocyte Biology. Journal of Investigative Dermatology, 138(8), pp. 1699-1706. Nature Publishing 10.1016/j.jid.2018.02.022

Ozhathil, Lijo Cherian; Delalande, Clémence Marie Sandrine; Bianchi, Beatrice; Nemeth, Gabor; Kappel, Sven; Thomet, Urs; Ross, Daniela; Simonin, Céline; Rubin, Matthias; Gertsch, Jürg; Lochner, Martin; Peinelt, Christine; Reymond, Jean-Louis; Abriel, Hugues (2018). Identification of potent and selective small molecule inhibitors of the cation channel TRPM4. British journal of pharmacology, 175(12), pp. 2504-2519. Wiley-Blackwell 10.1111/bph.14220

Gertsch, Jürg (2018). Analytical and Pharmacological Challenges in Cannabis Research. Planta medica, 84(4), p. 213. Thieme 10.1055/s-0044-101051

Aghazadeh Tabrizi, Mojgan; Baraldi, Pier Giovanni; Baraldi, Stefania; Ruggiero, Emanuela; De Stefano, Lucia; Rizzolio, Flavio; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Chicca, Andrea; Lapillo, Margherita; Gertsch, Jürg; Manera, Clementina; Macchia, Marco; Martinelli, Adriano; Granchi, Carlotta; Minutolo, Filippo; Tuccinardi, Tiziano (2018). Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors. Journal of medicinal chemistry, 61(3), pp. 1340-1354. American Chemical Society 10.1021/acs.jmedchem.7b01845

Varga, Zoltan V; Matyas, Csaba; Erdelyi, Katalin; Cinar, Resat; Nieri, Daniela; Chicca, Andrea; Nemeth, Balazs Tamas; Paloczi, Janos; Lajtos, Tamas; Corey, Lukas; Hasko, Gyorgy; Gao, Bin; Kunos, George; Gertsch, Jürg; Pacher, Pal (2018). Beta-caryophyllene protects against alcoholic steatohepatitis by attenuating inflammation and metabolic dysregulation in mice. British journal of pharmacology, 175(2), pp. 320-334. Wiley-Blackwell 10.1111/bph.13722

2017

Bertini, Simone; Chicca, Andrea; Gado, Francesca; Arena, Chiara; Nieri, Daniela; Digiacomo, Maria; Saccomanni, Giuseppe; Zhao, Pingwei; Abood, Mary E; Macchia, Marco; Gertsch, Jürg; Manera, Clementina (2017). Novel analogs of PSNCBAM-1 as allosteric modulators of cannabinoid CB1 receptor. Bioorganic & medicinal chemistry, 25(24), pp. 6427-6434. Elsevier 10.1016/j.bmc.2017.10.015

Chicca, Andrea; Berg, Regina; Jessen, Henning J; Marck, Nicolas; Schmid, Fabian; Burch, Patrick; Gertsch, Jürg; Gademann, Karl (2017). Biological evaluation of pyridone alkaloids on the endocannabinoid system. Bioorganic & medicinal chemistry, 25(22), pp. 6102-6114. Elsevier 10.1016/j.bmc.2017.02.031

Reynoso, Ines del Carmen; Najar-Guerrero, Israel; Escareño, Noé; Flores-Soto, Mario Eduardo; Gertsch, Jürg; Viveros-Paredes, Juan Manuel (2017). An Endocannabinoid Uptake Inhibitor from Black Pepper Exerts Pronounced Anti-Inflammatory Effects in Mice. Journal of agricultural and food chemistry, 65(43), pp. 9435-9442. American Chemical Society 10.1021/acs.jafc.7b02979

Patsenker, Eleonora; Chicca, Andrea; Petrucci, Vanessa; Moghadamrad, Sheida; De Gottardi, Andrea; Hampe, Jochen; Gertsch, Jürg; Semmo, Nasser; Stickel, Felix (2017). 4-O'-methylhonokiol protects from alcohol/carbon tetrachloride-induced liver injury in mice. Journal of molecular medicine JMM, 95(10), pp. 1077-1089. Springer 10.1007/s00109-017-1556-y

Petrucci, Vanessa; Chicca, Andrea; Glasmacher, Sandra Patricia; Paloczi, Janos; Cao, Zongxian; Pacher, Pal; Gertsch, Jürg (2017). Pepcan-12 (RVD-hemopressin) is a CB2 receptor positive allosteric modulator constitutively secreted by adrenals and in liver upon tissue damage. Scientific Reports, 7(1), p. 9560. Nature Publishing Group 10.1038/s41598-017-09808-8

von Rotz, Robin; Kometer, Michael; Dornbierer, Dario; Gertsch, Jürg; Gachet Otanez, Maria Salomé; Vollenweider, Franz X; Seifritz, Erich; Bosch, Oliver G; Quednow, Boris B (2017). Neuronal oscillations and synchronicity associated with gamma-hydroxybutyrate during resting-state in healthy male volunteers. Psychopharmacology, 234(13), pp. 1957-1968. Springer 10.1007/s00213-017-4603-z

Chicca, Andrea; Nicolussi, Simon; Bartholomäus, Ruben; Blunder, Martina; Aparisi Rey, Alejandro; Petrucci, Vanessa; Reynoso, Ines del Carmen; Viveros-Paredes, Juan Manuel; Dalghi Gens, Marianela Gisela; Lutz, Beat; Schiöth, Helgi B; Soeberdt, Michael; Abels, Christoph; Charles, Roch-Philippe; Altmann, Karl-Heinz; Gertsch, Jürg (2017). Chemical probes to potently and selectively inhibit endocannabinoid cellular reuptake. Proceedings of the National Academy of Sciences of the United States of America - PNAS, 114(25), E5006-E5015. National Academy of Sciences NAS 10.1073/pnas.1704065114

Gertsch, Jürg (2017). Cannabimimetic phytochemicals in the diet - an evolutionary link to food selection and metabolic stress adaptation? British journal of pharmacology, 174(11), pp. 1464-1483. Wiley-Blackwell 10.1111/bph.13676

El Mokh, Oussama; Ruffieux-Daidié, Dorothée; Rölli, Matthias Andreas; Stooss, Amandine; Phillips, Wayne A; Gertsch, Jürg; Dettmer, Matthias; Charles, Roch-Philippe (2017). Combined MEK and Pi3'-kinase inhibition reveals synergy in targeting thyroid cancer in vitro and in vivo. OncoTarget, 8(15), pp. 24604-24620. Impact Journals LLC 10.18632/oncotarget.15599

Gachet Otanez, Maria Salomé; Schubert, Alexandra; Calarco, Serafina; Boccard, Julien; Gertsch, Jürg (2017). Targeted metabolomics shows plasticity in the evolution of signaling lipids and uncovers old and new endocannabinoids in the plant kingdom. Scientific Reports, 7, p. 41177. Nature Publishing Group 10.1038/srep41177

Soethoudt, Marjolein; Grether, Uwe; Fingerle, Jürgen; Grim, Travis W; Fezza, Filomena; de Petrocellis, Luciano; Ullmer, Christoph; Rothenhäusler, Benno; Perret, Camille; van Gils, Noortje; Finlay, David; MacDonald, Christa; Chicca, Andrea; Gens, Marianela Dalghi; Stuart, Jordyn; de Vries, Henk; Mastrangelo, Nicolina; Xia, Lizi; Alachouzos, Georgios; Baggelaar, Marc P; ... (2017). Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity. Nature communications, 8(13958), p. 13958. Nature Publishing Group 10.1038/ncomms13958

Martínez-Pacheco, Heidy; Ramírez-Galicia, Guillermo; Vergara-Arias, Midalia; Gertsch, Jürg; Fragoso-Vázquez, Jonathan Manuel; Méndez-Luna, David; Abujamra, A L; Cristina, Cabrera-Pérez Laura; Cecilia, Rosales-Hernández Martha; Mendoza-Lujambio, I; Correa-Basurto, José (2017). Docking and QSAR studies of aryl-valproic acid derivatives to identify anti-proliferative agents targeting the HDAC8. Anti-cancer agents in medicinal chemistry, 17(7), pp. 927-940. Bentham Science Publishers

2016

Alferink, Judith; Specht, Sabine; Arends, Hannah; Schumak, Beatrix; Schmidt, Kim; Ruland, Christina; Lundt, Ramona; Kemter, Andrea; Dlugos, Andrea; Kuepper, Janina M; Poppensieker, Karola; Findeiss, Matthias; Albayram, Önder; Otte, David-M; Marazzi, Janine; Gertsch, Jürg; Förster, Irmgard; Maier, Wolfgang; Scheu, Stefanie; Hoerauf, Achim; ... (2016). Cannabinoid Receptor 2 Modulates Susceptibility to Experimental Cerebral Malaria through a CCL17-dependent Mechanism. Journal of biological chemistry, 291(37), pp. 19517-19531. American Society for Biochemistry and Molecular Biology 10.1074/jbc.M116.746594

Jantsch, Andrea; Nieto, Lidia; Gertsch, Jürg; Rodríguez-Salarichs, Javier; Matesanz, Ruth; Jiménez-Barbero, Jesús; Díaz, J Fernando; Canales, Ángeles; Altmann, Karl-Heinz (2016). Synthesis, Biological Profiling and Determination of the Tubulin-Bound Conformation of 12-Aza-Epothilones (Azathilones). Molecules, 21(8) Molecular Diversity Preservation International MDPI 10.3390/molecules21081010

Gertsch, Jürg (2016). The Metabolic Plant Feedback Hypothesis: How Plant Secondary Metabolites Nonspecifically Impact Human Health. Planta medica, 82(11-12), pp. 920-929. Thieme 10.1055/s-0042-108340

Bertini, Simone; Chicca, Andrea; Arena, Chiara; Chicca, Stefano; Saccomanni, Giuseppe; Gertsch, Jürg; Manera, Clementina; Macchia, Marco (2016). Synthesis and pharmacological evaluation of new biphenylic derivatives as CB2 receptor ligands. European journal of medicinal chemistry, 116, pp. 252-266. Elsevier Masson SAS 10.1016/j.ejmech.2016.03.072

Oláh, Attila; Ambrus, Lídia; Nicolussi, Simon; Gertsch, Jürg; Tubak, Vilmos; Kemény, Lajos; Soeberdt, Michael; Abels, Christoph; Bíró, Tamás (2016). Inhibition of fatty acid amide hydrolase exerts cutaneous anti-inflammatory effects both in vitro and in vivo. Experimental dermatology, 25(4), pp. 328-330. Blackwell 10.1111/exd.12930

Gertsch, Jürg (2016). Editorial: Lung macrophages high on cannabinoids: jamming PAMs and taming TAMs? Journal of leukocyte biology, 99(4), pp. 518-520. Society for Leukocyte Biology 10.1189/jlb.3CE0915-409RR

Rau, Mark; Nicolussi, Simon; Chicca, Andrea; Gertsch, Jürg (2016). Assay of Endocannabinoid Uptake. In: Maccarrone, Mauro (ed.) Endocannabinoid Signaling. Methods and Protocols. Methods in Molecular Biology: Vol. 1412 (pp. 191-203). New York: Springer 10.1007/978-1-4939-3539-0_20

2015

Liechti, Matthias E; Quednow, Boris B; Liakoni, Evangelia; Dornbierer, Dario; von Rotz, Robin; Gachet Otanez, Maria Salomé; Gertsch, Jürg; Seifritz, Erich; Bosch, Oliver G (2015). Pharmacokinetics and pharmacodynamics of γ-hydroxybutyrate in healthy subjects. British journal of clinical pharmacology, 81(5), pp. 980-988. Wiley-Blackwell 10.1111/bcp.12863

Bosch, Oliver G; Eisenegger, Christoph; Gertsch, Jürg; von Rotz, Robin; Dornbierer, Dario; Gachet Otanez, Maria Salomé; Heinrichs, Markus; Wetter, Thomas C; Seifritz, Erich; Quednow, Boris B (2015). Gamma-hydroxybutyrate enhances mood and prosocial behavior without affecting plasma oxytocin and testosterone. Psychoneuroendocrinology, 62, pp. 1-10. Elsevier 10.1016/j.psyneuen.2015.07.167

Gachet Otanez, Maria Salomé; Gertsch, Jürg (2015). Quantitative analysis of arachidonic acid, endocannabinoids, N-acylethanolamines and steroids in biological samples by LCMS/MS: Fit to purpose. Journal of chromatography. B - analytical technologies in the biomedical and life sciences, 1012-1013, pp. 215-221. Elsevier 10.1016/j.jchromb.2015.11.013

Iakovenko, Roman O; Kazakova, Anna N; Muzalevskiy, Vasiliy M; Ivanov, Alexander Yu; Boyarskaya, Irina A; Chicca, Andrea; Petrucci, Vanessa; Gertsch, Jürg; Krasavin, Mikhail; Starova, Galina L; Zolotarev, Andrey A; Avdontceva, Margarita S; Nenajdenko, Valentine G; Vasilyev, Aleksander V (2015). Reactions of CF3-enones with arenes under superelectrophilic activation: a pathway to trans-1,3-diaryl-1-CF3-indanes, new cannabinoid receptor ligands. Organic & biomolecular chemistry, 13(33), pp. 8827-8842. Royal Society of Chemistry 10.1039/c5ob01072a

Del Carlo, S; Manera, C; Chicca, Andrea; Arena, C; Bertini, S; Burgalassi, S; Tampucci, S; Gertsch, Jürg; Macchia, M; Saccomanni, G (2015). Development of an HPLC/UV assay for the evaluation of inhibitors of human recombinant monoacylglycerol lipase. Journal of pharmaceutical and biomedical analysis, 108, pp. 113-121. Pergamon Press 10.1016/j.jpba.2015.02.007

Hofer Reyes, Stefanie; Ralvenius, William T; Gachet Otanez, Maria Salomé; Fritschy, Jean-Marc; Zeilhofer, Ulrich; Gertsch, Jürg (2015). Localization and production of peptide endocannabinoids in the rodent CNS and adrenal medulla. Neuropharmacology, 98, pp. 78-89. Elsevier 10.1016/j.neuropharm.2015.03.021

Jack, Thomas; Simonin, Jonathan; Ruepp, Marc-David; Thompson, Andrew James; Gertsch, Jürg; Lochner, Martin (2015). Characterizing New Fluorescent Tools for Studying 5-HT3 Receptor Pharmacology. Neuropharmacology, 90, pp. 63-73. Elsevier 10.1016/j.neuropharm.2014.11.007

Gachet Otanez, Maria Salomé; Rhyn, Peter; Bosch, Oliver G; Quednow, Boris B; Gertsch, Jürg (2015). A quantitiative LC-MS/MS method for the measurement of arachidonic acid, prostanoids, endocannabinoids, N-acylethanolamines and steroids in human plasma. Journal of chromatography. B - analytical technologies in the biomedical and life sciences, 976-977, pp. 6-18. Elsevier 10.1016/j.jchromb.2014.11.001

Nicolussi, Simon; Gertsch, Jürg (2015). Endocannabinoid transport revisited. In: Litwack, Gerald (ed.) Vitamins and Hormones. Hormones and Transport Systems: Vol. 98 (pp. 441-485). Elsevier Inc. 10.1016/bs.vh.2014.12.011

Patsenker, Eleanora; Sachse, Philip; Chicca, Andrea; Gachet Otanez, Maria Salomé; Schneider, Vreni; Mattsson, Johan; Lanz, Christian; Worni, Mathias; De Gottardi, Andrea; Semmo, Mariam; Hampe, Jochen; Schafmayer, Clemens; Brenneisen, Rudolf Max; Gertsch, Jürg; Stickel, Felix; Semmo, Nasser (2015). Elevated levels of endocannabinoids in chronic hepatitis C may modulate cellular immune response and hepatic stellate cell activation. International journal of molecular sciences, 16(4), pp. 7057-7076. Molecular Diversity Preservation International MDPI 10.3390/ijms16047057

Chicca, Andrea; Gachet Otanez, Maria Salomé; Petrucci, Vanessa; Schuehly, Wolfgang; Charles, Roch-Philippe; Gertsch, Jürg (2015). 4'-O-methylhonokiol increases levels of 2-arachidonoyl glycerol in mouse brain via selective inhibition of its COX-2-mediated oxygenation. Journal of neuroinflammation, 12, p. 89. BioMed Central 10.1186/s12974-015-0307-7

2014

Nicolussi, Simon; Chicca, Andrea; Rau, Mark; Rihs, Sabine; Soeberdt, Michael; Abels, Christoph; Gertsch, Jürg (2014). Correlating FAAH and anandamide cellular uptake inhibition using N-alkylcarbamate inhibitors: from ultrapotent to hyperpotent. Biochemical pharmacology, 92(4), pp. 669-689. Elsevier 10.1016/j.bcp.2014.09.020

Rosati, Ornelio; Messina, Federica; Pelosi, Azzurra; Curini, Massimo; Petrucci, Vanessa; Gertsch, Jürg; Chicca, Andrea (2014). One-pot heterogeneous synthesis of Δ(3)-tetrahydrocannabinol analogues and xanthenes showing differential binding to CB(1) and CB(2) receptors. European journal of medicinal chemistry, 85, pp. 77-86. Elsevier Masson SAS 10.1016/j.ejmech.2014.07.062

Marini, Camilla; Lüscher, Benjamin; Jörger Messerli, Marianne; Sager, Ruth; Huang, Xiao; Gertsch, Jürg; Hediger, Matthias; Albrecht, Christiane; Baumann, Marc Ulrich; Surbek, Daniel (September 2014). PLACENTAL GLUCOSE TRANSPORTER (GLUT)-1 REGULATION IN PREECLAMPSIA. Placenta, 35, A83-A84. Elsevier

Hajdu, Zsanett; Nicolussi, Simon; Rau, Mark; Lorántfy, László; Forgo, Peter; Hohmann, Judit; Csupor, Dezső; Gertsch, Jürg (2014). Identification of endocannabinoid system-modulating N-alkylamides from Heliopsis helianthoides var. scabra and Lepidium meyenii. Journal of natural products, 77(7), pp. 1663-1669. American Chemical Society 10.1021/np500292g

Chicca, Andrea; Caprioglio, Diego; Minassi, Alberto; Petrucci, Vanessa; Appendino, Giovanni; Taglialatela-Scafati, Orazio; Gertsch, Jürg (2014). Functionalization of β-caryophyllene generates novel polypharmacology in the endocannabinoid system. ACS Chemical Biology, 9(7), pp. 1499-1507. American Chemical Society 10.1021/cb500177c

Bürgi, Justus; Awale, Mahendra; Boss, Silvan D.; Schaer, Tifany; Marger, Fabrice; Viveros Paredes, Juan Manuel; Bertrand, Sonia; Gertsch, Jürg; Bertrand, Daniel; Reymond, Jean-Louis (2014). Discovery of Potent Positive Allosteric Modulators of the α3β2 Nicotinic Acetylcholine Receptor by a Chemical Space Walk in ChEMBL. ACS chemical neuroscience, 5(5), pp. 346-359. American Chemical Society 10.1021/cn4002297

Ilgü, Hüseyin; Jeckelmann, Jean-Marc; Gachet Otanez, Maria Salomé; Boggavarapu, Venkata Ravi Naga Rajendr; Ucurum Fotiadis, Zöhre; Gertsch, Jürg; Fotiadis, Dimitrios José (2014). Variation of the detergent-binding capacity and phospholipid content of membrane proteins when purified in different detergents. Biophysical journal, 106(8), pp. 1660-1670. Biophysical Society 10.1016/j.bpj.2014.02.024

Klauke, A.-L.; Racz, I.; Pradier, B.; Markert, A.; Zimmer, A. M.; Gertsch, J.; Zimmer, A. (2014). The cannabinoid CB2 receptor-selective phytocannabinoid beta-caryophyllene exerts analgesic effects in mouse models of inflammatory and neuropathic pain. European neuropsychopharmacology, 24(4), pp. 608-620. Elsevier 10.1016/j.euroneuro.2013.10.008

Marini, Camilla; Lüscher, Benjamin; Jörger Messerli, Marianne; Sager, Ruth; Huang, Xiao; Gertsch, Jürg; Hediger, Matthias; Albrecht, Christiane; Baumann, Marc Ulrich; Surbek, Daniel (March 2014). Placental Glucose Transporter (GLUT1) Expression in Pre-Eclampsia. Reproductive sciences, 21(3), 304A-304A. Sage

Burch, Patrick; Chicca, Andrea; Gertsch, Jürg; Gademann, Karl (2014). Functionally Optimized Neuritogenic Farinosone C Analogs: SAR-Study and Investigations on Their Mode of Action. ACS medicinal chemistry letters, 5(2), pp. 172-177. American Chemical Society 10.1021/ml400435h

Nicolussi, Simon; Viveros Paredes, Juan Manuel; Gachet Otanez, Maria Salomé; Rau, Mark; Flores-Soto, Mario Eduardo; Blunder, Martina; Gertsch, Jürg (2014). Guineensine is a novel inhibitor of endocannabinoid uptake showing cannabimimetic behavioral effects in BALB/c mice. Pharmacological research, 80, pp. 52-65. Elsevier 10.1016/j.phrs.2013.12.010

2013

Wullschleger, Christoph W.; Gertsch, Jürg; Altmann, Karl-Heinz (2013). Synthesis and Biological Activity of 7,8,9-Trideoxy- and 7 R DesTHP-Peloruside A. Chemistry - a European journal, 19(39), pp. 13105-13111. Wiley-VCH 10.1002/chem.201301796

Baur, Roland; Gertsch, Jürg; Sigel, Erwin (2013). Do N-arachidonyl-glycine (NA-glycine) and 2-arachidonoyl glycerol (2-AG) share mode of action and the binding site on the β 2 subunit of GABA A receptors? PeerJ, 1, e149. PeerJ, Ltd 10.7717/peerj.149

Simonin, Jonathan; Jack, Thomas; Ruepp, Marc-David; Hothersall, Daniel; Connolly, Christopher; Chicca, Andrea; Gertsch, Jürg; Thompson, Andrew James; Lummis, Sarah C. R.; Lochner, Martin (August 2013). Synthesis of fluorescent probes for the study of the 5-HT3 receptor: applications in imaging and fluorescence polarization. CHIMIA, 67(7/8), p. 524. Schweizerische Chemische Gesellschaft

Leonti, Marco; Cabras, Stefano; Eugenia Castellanos, Maria; Challenger, Antony; Gertsch, Jürg; Casu, Laura (2013). Bioprospecting: Evolutionary implications from a post-olmec pharmacopoeia and the relevance of widespread taxa. Journal of ethnopharmacology, 147(1), pp. 92-107. Elsevier Science Ireland 10.1016/j.jep.2013.02.012

Pfeiffer, Bernhard; Speck-Gisler, Sandra; Barandun, Luzi; Senft, Ursula; de Groot, Claire; Lehmann, Irène; Ganci, Walter; Gertsch, Jürg; Altmann, Karl-Heinz (2013). Total Synthesis and Configurational Assignment of the Marine Natural Product Haliclamide. The Journal of organic chemistry, 78(6), pp. 2553-2563. American Chemical Society 10.1021/jo3027643

2012

Gertsch, Jürg (2012). Cross-cultural comparisons of medicinal floras--what are the implications for bioprospecting? Journal of ethnopharmacology, 139(3), 685-7; discussion 688-90. Shannon: Elsevier Science Ireland 10.1016/j.jep.2011.09.017

Kleyer, Jonas; Nicolussi, Simon; Taylor, Peter; Simonelli, Deborah; Furger, Evelyne; Anderle, Pascale; Gertsch, Jürg (2012). Cannabinoid receptor trafficking in peripheral cells is dynamically regulated by a binary biochemical switch. Biochemical pharmacology, 83(10), pp. 1393-412. New York, N.Y.: Elsevier 10.1016/j.bcp.2012.02.014

Baur, R; Gertsch, J; Sigel, E (2012). The cannabinoid CB1 receptor antagonists rimonabant (SR141716) and AM251 directly potentiate GABA(A) receptors. British journal of pharmacology, 165(8), pp. 2479-84. Oxford: Wiley-Blackwell 10.1111/j.1476-5381.2011.01405.x

Zurwerra, Didier; Glaus, Florian; Betschart, Leo; Schuster, Julia; Gertsch, Jürg; Ganci, Walter; Altmann, Karl-Heinz (2012). Total synthesis of (-)-zampanolide and structure-activity relationship studies on (-)-dactylolide derivatives. Chemistry - a European journal, 18(52), pp. 16868-83. Weinheim: Wiley-VCH 10.1002/chem.201202553

Bauer, Mark; Chicca, Andrea; Tamborrini, Marco; Eisen, David; Lerner, Raissa; Lutz, Beat; Poetz, Oliver; Pluschke, Gerd; Gertsch, Jürg (2012). Identification and quantification of a new family of peptide endocannabinoids (Pepcans) showing negative allosteric modulation at CB1 receptors. Journal of biological chemistry, 287(44), pp. 36944-67. Bethesda, Md.: American Society for Biochemistry and Molecular Biology 10.1074/jbc.M112.382481

Serra, Silvia; Chicca, Andrea; Delogu, Giovanna; Vázquez-Rodríguez, Saleta; Santana, Lourdes; Uriarte, Eugenio; Casu, Laura; Gertsch, Jürg (2012). Synthesis and cytotoxic activity of non-naturally substituted 4-oxycoumarin derivatives. Bioorganic and medicinal chemistry letters, 22(18), pp. 5791-4. New York, N.Y.: Pergamon 10.1016/j.bmcl.2012.07.099

Chicca, Andrea; Marazzi, Janine; Nicolussi, Simon; Gertsch, Jürg (2012). Evidence for bidirectional endocannabinoid transport across cell membranes. Journal of biological chemistry, 287(41), pp. 34660-82. Bethesda, Md.: American Society for Biochemistry and Molecular Biology 10.1074/jbc.M112.373241

Chicca, A; Marazzi, J; Gertsch, J (2012). The antinociceptive triterpene β-amyrin inhibits 2-arachidonoylglycerol (2-AG) hydrolysis without directly targeting cannabinoid receptors. British journal of pharmacology, 167(8), pp. 1596-608. Oxford: Wiley-Blackwell 10.1111/j.1476-5381.2012.02059.x

Yang, Peng; Myint, Kyaw-Zeyar; Tong, Qin; Feng, Rentian; Cao, Haiping; Almehizia, Abdulrahman A; Alqarni, Mohammed Hamed; Wang, Lirong; Bartlow, Patrick; Gao, Yingdai; Gertsch, Jürg; Teramachi, Jumpei; Kurihara, Noriyoshi; Roodman, Garson David; Cheng, Tao; Xie, Xiang-Qun (2012). Lead discovery, chemistry optimization, and biological evaluation studies of novel biamide derivatives as CB2 receptor inverse agonists and osteoclast inhibitors. Journal of medicinal chemistry, 55(22), pp. 9973-87. Easton, Pa.: American Chemical Society 10.1021/jm301212u

Bénard, Giovanni; Massa, Federico; Puente, Nagore; Lourenço, Joana; Bellocchio, Luigi; Soria-Gómez, Edgar; Matias, Isabel; Delamarre, Anna; Metna-Laurent, Mathilde; Cannich, Astrid; Hebert-Chatelain, Etienne; Mulle, Christophe; Ortega-Gutiérrez, Silvia; Martín-Fontecha, Mar; Klugmann, Matthias; Guggenhuber, Stephan; Lutz, Beat; Gertsch, Jürg; Chaouloff, Francis; López-Rodríguez, María Luz; ... (2012). Mitochondrial CB₁ receptors regulate neuronal energy metabolism. Nature neuroscience, 15(4), pp. 558-64. New York, N.Y.: Nature America 10.1038/nn.3053

Horváth, Béla; Mukhopadhyay, Partha; Kechrid, Malek; Patel, Vivek; Tanchian, Galin; Wink, David A; Gertsch, Jürg; Pacher, Pál (2012). β-Caryophyllene ameliorates cisplatin-induced nephrotoxicity in a cannabinoid 2 receptor-dependent manner. Free radical biology & medicine, 52(8), pp. 1325-33. San Diego, Calif.: Elsevier 10.1016/j.freeradbiomed.2012.01.014

Anavi-Goffer, Sharon; Baillie, Gemma; Irving, Andrew J; Gertsch, Jürg; Greig, Iain R; Pertwee, Roger G; Ross, Ruth A (2012). Modulation of L-α-lysophosphatidylinositol/GPR55 mitogen-activated protein kinase (MAPK) signaling by cannabinoids. Journal of biological chemistry, 287(1), pp. 91-104. Bethesda, Md.: American Society for Biochemistry and Molecular Biology 10.1074/jbc.M111.296020

Gertsch, J; Anavi-Goffer, S (2012). Methylhonokiol attenuates neuroinflammation: a role for cannabinoid receptors? 9. J Neuroinflammation 10.1186/1742-2094-9-135

2011

Gertsch, Jürg; Viveros Paredes, Juan Manuel; Taylor, Peter (2011). Plant immunostimulants-Scientific paradigm or myth? Journal of ethnopharmacology, 136(3), pp. 385-391. Shannon: Elsevier Science Ireland 10.1016/j.jep.2010.06.044

Sigel, Erwin; Baur, Roland; Rácz, Ildiko; Marazzi, Janine; Smart, Trevor G; Zimmer, Andreas; Gertsch, Jürg (2011). The major central endocannabinoid directly acts at GABA(A) receptors. Proceedings of the National Academy of Sciences of the United States of America - PNAS, 108(44), pp. 18150-5. Washington, D.C.: National Academy of Sciences NAS 10.1073/pnas.1113444108

Marazzi, Janine; Kleyer, Jonas; Paredes, Juan Manuel Viveros; Gertsch, Jürg (2011). Endocannabinoid content in fetal bovine sera - unexpected effects on mononuclear cells and osteoclastogenesis. Journal of immunological methods, 373(1-2), pp. 219-28. Amsterdam: Elsevier 10.1016/j.jim.2011.08.021

Nievergelt, Andreas; Marazzi, Janine; Schoop, Roland; Altmann, Karl-Heinz; Gertsch, Jürg (2011). Ginger phenylpropanoids inhibit IL-1beta and prostanoid secretion and disrupt arachidonate-phospholipid remodeling by targeting phospholipases A2. Journal of immunology, 187(8), pp. 4140-50. Bethesda, Md.: American Association of Immunologists 10.4049/jimmunol.1100880

Schuehly, Wolfgang; Paredes, Juan Manuel Viveros; Kleyer, Jonas; Huefner, Antje; Anavi-Goffer, Sharon; Raduner, Stefan; Altmann, Karl-Heinz; Gertsch, Jürg (2011). Mechanisms of osteoclastogenesis inhibition by a novel class of biphenyl-type cannabinoid CB(2) receptor inverse agonists. Chemistry & biology, 18(8), pp. 1053-64. San Francisco, Calif.: Current Biology Ltd. 10.1016/j.chembiol.2011.05.012

Ritchie, M R; Gertsch, J; Klein, P; Schoop, R (2011). Effects of Echinaforce® treatment on ex vivo-stimulated blood cells. Phytomedicine, 18(10), pp. 826-31. Amsterdam: Elsevier 10.1016/j.phymed.2011.05.011

Maffei, Massimo E; Gertsch, Jürg; Appendino, Giovanni (2011). Plant volatiles: production, function and pharmacology. Natural product reports, 28(8), pp. 1359-80. Cambridge: Royal Society of Chemistry 10.1039/c1np00021g

Gertsch, Jürg (2011). Natural products in chemical biology. Current drug targets, 12(11), pp. 1513-4. Hilversum: Bentham Science Publishers 10.2174/138945011798109518

Ramesha, B T; Gertsch, Jürg; Ravikanth, G; Priti, V; Ganeshaiah, K N; Uma Shaanker, R (2011). Biodiversity and chemodiversity: future perspectives in bioprospecting. Current drug targets, 12(11), pp. 1515-30. Hilversum: Bentham Science Publishers

Zhang, Yuxun; Xie, Zhaojun; Wang, Lirong; Schreiter, Brielle; Lazo, John S; Gertsch, Jurg; Xie, Xiang-Qun (2011). Mutagenesis and computer modeling studies of a GPCR conserved residue W5.43(194) in ligand recognition and signal transduction for CB2 receptor. International immunopharmacology, 11(9), pp. 1303-10. Amsterdam: Elsevier 10.1016/j.intimp.2011.04.013

Gertsch, Jürg (2011). Botanical drugs, synergy, and network pharmacology: forth and back to intelligent mixtures. Planta medica, 77(11), pp. 1086-98. Stuttgart: Thieme 10.1055/s-0030-1270904

Schiess, Raphael; Gertsch, Jürg; Schweizer, W Bernd; Altmann, Karl-Heinz (2011). Stereoselective synthesis of 12,13-cyclopropyl-epothilone B and side-chain-modified variants. Organic letters, 13(6), pp. 1436-9. Washington, D.C.: American Chemical Society 10.1021/ol200114k

2010

Dietrich, Silvia Anthoine; Riediker, Linda; Gertsch, Jürg; Altmann, Karl-Heinz (2010). Synthesis and biological activity of new functionalized epothilones for prodrug design and tumor targeting. CHIMIA, 64(3), pp. 136-9. Bern: Schweizerische Chemische Gesellschaft 10.2533/chimia.2010.136

Altmann, Karl-Heinz; Cachoux, Frédéric; Feyen, Fabian; Gertsch, Jürg; Kuzniewski, Christian N; Wartmann, Markus (2010). Natural products as leads for anticancer drug discovery: discovery of new chemotypes of microtubule stabilizers through reengineering of the epothilone scaffold. CHIMIA, 64(1-2), pp. 8-13. Bern: Schweizerische Chemische Gesellschaft 10.2533/chimia.2010.8

Gertsch, Jürg; Pertwee, Roger G; Di Marzo, Vincenzo (2010). Phytocannabinoids beyond the Cannabis plant - do they exist? British journal of pharmacology, 160(3), pp. 523-9. Oxford: Wiley-Blackwell 10.1111/j.1476-5381.2010.00745.x

De Simone, Filippo; Gertsch, Jürg; Waser, Jérôme (2010). Catalytic selective cyclizations of aminocyclopropanes: formal synthesis of aspidospermidine and total synthesis of goniomitine. Angewandte Chemie (International ed.), 49(33), pp. 5767-70. Weinheim: Wiley-VCH 10.1002/anie.201001853

Leonti, Marco; Casu, Laura; Solinas, Maria Novella; Cottiglia, Filippo; Caboni, Pierluigi; Floris, Costantino; Gertsch, Juerg; Saba, Anna Rita (2010). A chromone from Seseli praecox (Apiaceae). Natural product communications, 5(4), pp. 551-4. Westerville, Ohio: Natural Product Communications NPC

Erdélyi, Máté; Navarro-Vázquez, Armando; Pfeiffer, Bernhard; Kuzniewski, Christian N; Felser, Andrea; Widmer, Toni; Gertsch, Jürg; Pera, Benet; Díaz, José Fernando; Altmann, Karl-Heinz; Carlomagno, Teresa (2010). The binding mode of side chain- and C3-modified epothilones to tubulin. ChemMedChem, 5(6), pp. 911-920. Weinheim: Wiley-VCH 10.1002/cmdc.201000050

Zurwerra, Didier; Gertsch, Jürg; Altmann, Karl-Heinz (2010). Synthesis of (-)-dactylolide and 13-desmethylene-(-)-dactylolide and their effects on tubulin. Organic letters, 12(10), pp. 2302-5. Washington, D.C.: American Chemical Society 10.1021/ol100665m

Nievergelt, Andreas; Huonker, Peter; Schoop, Roland; Altmann, Karl-Heinz; Gertsch, Jürg (2010). Identification of serotonin 5-HT1A receptor partial agonists in ginger. Bioorganic & medicinal chemistry, 18(9), pp. 3345-51. Amsterdam: Elsevier 10.1016/j.bmc.2010.02.062

Leonti, Marco; Casu, Laura; Gertsch, Jürg; Bonsignore, Leonardo; Floris, Costantino; Casu, Mariano; Cottiglia, Filippo (2010). A pterocarpan from the seeds of Bituminaria morisiana. Journal of natural medicines, 64(3), pp. 354-7. Tōkyō: Springer 10.1007/s11418-010-0408-7

Shwe, Htay Htay; Aye, Mye; Sein, Myint Myint; Htay, Khin Than; Kreitmeier, Peter; Gertsch, Jürg; Reiser, Oliver; Heilmann, Jörg (2010). Cytotoxic steroidal saponins from the rhizomes of Tacca integrifolia. Chemistry & Biodiversity, 7(3), pp. 610-22. Zürich: Verlag Helvetica Chimica Acta

Leonti, Marco; Casu, Laura; Raduner, Stefan; Cottiglia, Filippo; Floris, Costantino; Altmann, Karl-Heinz; Gertsch, Jürg (2010). Falcarinol is a covalent cannabinoid CB1 receptor antagonist and induces pro-allergic effects in skin. Biochemical pharmacology, 79(12), pp. 1815-26. New York, N.Y.: Elsevier 10.1016/j.bcp.2010.02.015

Wullschleger, Christoph W; Gertsch, Jürg; Altmann, Karl-Heinz (2010). Stereoselective synthesis of a monocyclic peloruside a analogue. Organic letters, 12(5), pp. 1120-3. Washington, D.C.: American Chemical Society 10.1021/ol100123p

Peng, Jiangnan; Kudrimoti, Sucheta; Prasanna, Sivaprakasam; Odde, Srinivas; Doerksen, Robert J; Pennaka, Hari K; Choo, Yeun-Mun; Rao, Karumanchi V; Tekwani, Babu L; Madgula, Vamsi; Khan, Shabana I; Wang, Bin; Mayer, Alejandro M S; Jacob, Melissa R; Tu, Lan Chun; Gertsch, Jürg; Hamann, Mark T (2010). Structure-activity relationship and mechanism of action studies of manzamine analogues for the control of neuroinflammation and cerebral infections. Journal of medicinal chemistry, 53(1), pp. 61-76. Easton, Pa.: American Chemical Society

2009

Gertsch, Jürg; Meier, Sarah; Müller, Martin; Altmann, Karl-Heinz (2009). Differential effects of natural product microtubule stabilizers on microtubule assembly: single agent and combination studies with taxol, epothilone B, and discodermolide. ChemBioChem, 10(1), pp. 166-75. Weinheim: Wiley-VCH 10.1002/cbic.200800556

Passarella, Daniele; Comi, Daniela; Cappelletti, Graziella; Cartelli, Daniele; Gertsch, Juerg; Quesada, Ana R; Borlak, Jurgen; Altmann, Karl-Heinz (2009). Synthesis and biological evaluation of epothilone A dimeric compounds. Bioorganic & medicinal chemistry, 17(21), pp. 7435-40. Amsterdam: Elsevier 10.1016/j.bmc.2009.09.032

Dietrich, Silvia Anthoine; Lindauer, Renate; Stierlin, Claire; Gertsch, Jürg; Matesanz, Ruth; Notararigo, Sara; Díaz, José Fernando; Altmann, Karl-Heinz (2009). Epothilone analogues with benzimidazole and quinoline side chains: chemical synthesis, antiproliferative activity, and interactions with tubulin. Chemistry - a European journal, 15(39), pp. 10144-57. Weinheim: Wiley-VCH 10.1002/chem.200901376

Oesch, Susanne; Gertsch, Jürg (2009). Cannabinoid receptor ligands as potential anticancer agents--high hopes for new therapies? Journal of pharmacy and pharmacology, 61(7), pp. 839-53. London: Royal Pharmaceutical Society of Great Britain 10.1211/jpp/61.07.0002

Pfeiffer, Bernhard; Hauenstein, Kurt; Merz, Philipp; Gertsch, Jürg; Altmann, Karl-Heinz (2009). Synthesis and SAR of C12-C13-oxazoline derivatives of epothilone A. Bioorganic and medicinal chemistry letters, 19(14), pp. 3760-3. New York, N.Y.: Pergamon 10.1016/j.bmcl.2009.04.112

Gollner, Andreas; Altmann, Karl-Heinz; Gertsch, Jürg; Mulzer, Johann (2009). The laulimalide family: total synthesis and biological evaluation of neolaulimalide, isolaulimalide, laulimalide and a nonnatural analogue. Chemistry - a European journal, 15(24), pp. 5979-97. Weinheim: Wiley-VCH 10.1002/chem.200802605

Chicca, Andrea; Raduner, Stefan; Pellati, Federica; Strompen, Thomas; Altmann, Karl-Heinz; Schoop, Roland; Gertsch, Jürg (2009). Synergistic immunomopharmacological effects of N-alkylamides in Echinacea purpurea herbal extracts. International immunopharmacology, 9(7-8), pp. 850-8. Amsterdam: Elsevier 10.1016/j.intimp.2009.03.006

Gertsch, Jürg (2009). How scientific is the science in ethnopharmacology? Historical perspectives and epistemological problems. Journal of ethnopharmacology, 122(2), pp. 177-83. Shannon: Elsevier Science Ireland 10.1016/j.jep.2009.01.010

Markt, Patrick; Feldmann, Clemens; Rollinger, Judith Maria; Raduner, Stefan; Schuster, Daniela; Kirchmair, Johannes; Distinto, Simona; Spitzer, Gudrun Maria; Wolber, Gerhard; Laggner, Christian; Altmann, Karl-Heinz; Langer, Thierry; Gertsch, Jürg (2009). Discovery of novel CB2 receptor ligands by a pharmacophore-based virtual screening workflow. Journal of medicinal chemistry, 52(2), pp. 369-78. Easton, Pa.: American Chemical Society 10.1021/jm801044g

Rollinger, Judith M; Schuster, Daniela; Danzl, Birgit; Schwaiger, Stefan; Markt, Patrick; Schmidtke, Michaela; Gertsch, Jürg; Raduner, Stefan; Wolber, Gerhard; Langer, Thierry; Stuppner, Hermann (2009). In silico target fishing for rationalized ligand discovery exemplified on constituents of Ruta graveolens. Planta medica, 75(3), pp. 195-204. Stuttgart: Thieme 10.1055/s-0028-1088397

Gertsch, Jürg; Feyen, Fabian; Bützberger, Alexander; Gerber, Barbara; Pfeiffer, Bernhard; Altmann, Karl-Heinz (2009). Making epothilones fluoresce: design, synthesis, and biological characterization of a fluorescent N12-aza-epothilone (azathilone). ChemBioChem, 10(15), pp. 2513-21. Weinheim: Wiley-VCH 10.1002/cbic.200900376

Gollner, A; Altmann, K.-H; Gertsch, J; Mulzer, J (2009). Synthesis and biological evaluation of a des-dihydropyran laulimalide analog. Tetrahedron letters, 50(42), pp. 5790-5792. Amsterdam: Elsevier 10.1016/j.tetlet.2009.07.122

2008

Gertsch, Jürg; Leonti, Marco; Raduner, Stefan; Racz, Ildiko; Chen, Jian-Zhong; Xie, Xiang-Qun; Altmann, Karl-Heinz; Karsak, Meliha; Zimmer, Andreas (2008). Beta-caryophyllene is a dietary cannabinoid. Proceedings of the National Academy of Sciences of the United States of America - PNAS, 105(26), pp. 9099-104. Washington, D.C.: National Academy of Sciences NAS 10.1073/pnas.0803601105

Kuzniewski, Christian N; Gertsch, Jürg; Wartmann, Markus; Altmann, Karl-Heinz (2008). Total synthesis of hypermodified epothilone analogs with potent in vitro antitumor activity. Organic letters, 10(6), pp. 1183-6. Washington, D.C.: American Chemical Society 10.1021/ol800089x

Gertsch, Jürg (2008). Immunomodulatory lipids in plants: plant fatty acid amides and the human endocannabinoid system. Planta medica, 74(6), pp. 638-50. Stuttgart: Thieme 10.1055/s-2008-1034302

Erdélyi, Máté; Pfeiffer, Bernhard; Hauenstein, Kurt; Fohrer, Jörg; Gertsch, Jürg; Altmann, Karl-Heinz; Carlomagno, Teresa (2008). Conformational preferences of natural and C3-modified epothilones in aqueous solution. Journal of medicinal chemistry, 51(5), pp. 1469-73. Easton, Pa.: American Chemical Society 10.1021/jm7013452

Hamel, Cotinica; Prusov, Evgeny V; Gertsch, Jürg; Schweizer, W Bernd; Altmann, Karl-Heinz (2008). Total synthesis of the marine diterpenoid blumiolide C. Angewandte Chemie (International ed.), 47(52), pp. 10081-5. Weinheim: Wiley-VCH 10.1002/anie.200804004

Collu, Francesca; Bonsignore, Leonardo; Casu, Mariano; Floris, Costantino; Gertsch, Jürg; Cottiglia, Filippo (2008). New cytotoxic saturated and unsaturated cyclohexanones from Anthemis maritima. Bioorganic and medicinal chemistry letters, 18(5), pp. 1559-62. New York, N.Y.: Pergamon 10.1016/j.bmcl.2008.01.078

Feyen, Fabian; Cachoux, Frédéric; Gertsch, Jürg; Wartmann, Markus; Altmann, Karl-Heinz (2008). Epothilones as lead structures for the synthesis-based discovery of new chemotypes for microtubule stabilization. Accounts of chemical research, 41(1), pp. 21-31. Easton, Pa.: American Chemical Society 10.1021/ar700157x

2007

Raduner, Stefan; Bisson, William; Abagyan, Ruben; Altmann, Karl-Heinz; Gertsch, Jürg (2007). Self-assembling cannabinomimetics: supramolecular structures of N-alkyl amides. Journal of natural products, 70(6), pp. 1010-5. Washington, D.C.: American Chemical Society 10.1021/np060598+

Modarai, M; Gertsch, J; Suter, A; Heinrich, M; Kortenkamp, A (2007). Cytochrome P450 inhibitory action of Echinacea preparations differs widely and co-varies with alkylamide content. Journal of pharmacy and pharmacology, 59(4), pp. 567-73. London: Royal Pharmaceutical Society of Great Britain 10.1211/jpp.59.4.0012

Altmann, Karl-Heinz; Gertsch, Jürg (2007). Anticancer drugs from nature--natural products as a unique source of new microtubule-stabilizing agents. Natural product reports, 24(2), pp. 327-57. Cambridge: Royal Society of Chemistry 10.1039/b515619j

2006

Gertsch, Jürg; Raduner, Stefan; Altmann, Karl-Heinz (2006). New natural noncannabinoid ligands for cannabinoid type-2 (CB2) receptors. Journal of receptor and signal transduction research, 26(5-6), pp. 709-30. New York, N.Y.: Marcel Dekker 10.1080/10799890600942674

Feyen, Fabian; Gertsch, Jürg; Wartmann, Markus; Altmann, Karl-Heinz (2006). Design and synthesis of 12-aza-epothilones (azathilones)--"non-natural" natural products with potent anticancer activity. Angewandte Chemie (International ed.), 45(35), pp. 5880-5. Weinheim: Wiley-VCH 10.1002/anie.200601359

Raduner, Stefan; Majewska, Adriana; Chen, Jian-Zhong; Xie, Xiang-Qun; Hamon, Jacques; Faller, Bernard; Altmann, Karl-Heinz; Gertsch, Jürg (2006). Alkylamides from Echinacea are a new class of cannabinomimetics. Cannabinoid type 2 receptor-dependent and -independent immunomodulatory effects. Journal of biological chemistry, 281(20), pp. 14192-206. Bethesda, Md.: American Society for Biochemistry and Molecular Biology 10.1074/jbc.M601074200

Casu, Laura; Bonsignore, Leonardo; Pinna, Manuela; Casu, Mariano; Floris, Costantino; Gertsch, Jürg; Cottiglia, Filippo (2006). Cytotoxic diacetylenic spiroketal enol ethers from Plagius flosculosus. Journal of natural products, 69(2), pp. 295-8. Washington, D.C.: American Chemical Society 10.1021/np0504513

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