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Lundström-Stadelmann, Britta; Rufener, Reto; Ritler, Dominic; Zurbriggen, Raphael Peter; Hemphill, Andrew (2019). The importance of being parasiticidal… an update on drug development for the treatment of alveolar echinococcosis. Food and waterborne parasitology, 15, e00040. Elsevier 10.1016/j.fawpar.2019.e00040
Silva Pinto Basto, Afonso; Anghel, Nicoleta; Rubbiani, Riccardo; Müller, Joachim; Stibal, David; Giannini, Federico; Süss-Fink, Georg; Balmer, Vreni; Gasser, Gilles; Furrer, Julien; Hemphill, Andrew (2019). Targeting of the mitochondrion by dinuclear thiolato-bridged arene ruthenium complexes in cancer cells and in the apicomplexan parasite Neospora caninum. Metallomics, 11(2), pp. 462-474. Royal Society of Chemistry 10.1039/C8MT00307F
García-Lunar, P; Schares, G; Sanz-Fernández, A; Jiménez-Meléndez, A; García-Soto, I; Regidor-Cerrillo, J; Pastor-Fernández, I; Hemphill, Andrew; Fernández-Álvarez, M; Ortega-Mora, L M; Álvarez-García, G (2019). Development and characterization of monoclonal antibodies against Besnoitia besnoiti tachyzoites. Parasitology, 146(2), pp. 187-196. Cambridge University Press 10.1017/S0031182018001336
Aguado Martinez, Adriana; Basto, Afonso P; Tanaka, Shun; Ryser, Lorenz T; Nunes, Telmo P; Ortega-Mora, Luis-Miguel; Arranz-Solís, David; Leitão, Alexandre; Hemphill, Andrew (2019). Immunization with a cocktail of antigens fused with OprI reduces Neospora caninum vertical transmission and postnatal mortality in mice. Vaccine, 37(3), pp. 473-483. Elsevier 10.1016/j.vaccine.2018.11.060
Sánchez-Sánchez, Roberto; Ferre, Ignacio; Regidor-Cerrillo, Javier; Gutiérrez-Expósito, Daniel; Ferrer, Luis Miguel; Arteche-Villasol, Noive; Moreno-Gonzalo, Javier; Müller, Joachim; Aguado Martinez, Adriana; Pérez, Valentín; Hemphill, Andrew; Ortega-Mora, Luis Miguel; Benavides, Julio (2019). Virulence in Mice of a Toxoplasma gondii Type II Isolate Does Not Correlate With the Outcome of Experimental Infection in Pregnant Sheep. Frontiers in cellular and infection microbiology, 8(436), p. 436. Frontiers 10.3389/fcimb.2018.00436
Müller, Joachim; Manser, Vera; Hemphill, Andrew (2019). In vitro treatment of Besnoitia besnoiti with the naphto-quinone buparvaquone results in marked inhibition of tachyzoite proliferation, mitochondrial alterations and rapid adaptation of tachyzoites to increased drug concentrations. Parasitology, 146(1), pp. 112-120. Cambridge University Press 10.1017/S0031182018000975
Anghel, Nicoleta; Balmer, Vreni; Müller, Joachim; Winzer, Pablo Arnold; Aguado Martinez, Adriana; Roozbehani, Mona; Pou, Sovitj; Nilsen, Aaron; Riscoe, Michael; Doggett, J Stone; Hemphill, Andrew (2018). Endochin-Like Quinolones Exhibit Promising Efficacy Against Neospora Caninum in vitro and in Experimentally Infected Pregnant Mice. Frontiers in veterinary science, 5, p. 285. Frontiers Media 10.3389/fvets.2018.00285
Roozbehani, Mona; Falak, Reza; Mohammadi, Mohsen; Hemphill, Andrew; Razmjou, Elham; Meamar, Ahmad Reza; Masoori, Leila; Khoshmirsafa, Majid; Moradi, Maryam; Gharavi, Mohammad Javad (2018). Characterization of a multi-epitope peptide with selective MHC-binding capabilities encapsulated in PLGA nanoparticles as a novel vaccine candidate against Toxoplasma gondii infection. Vaccine, 36(41), pp. 6124-6132. Elsevier 10.1016/j.vaccine.2018.08.068
Jiménez-Meléndez, Alejandro; Rico-San Román, Laura; Hemphill, Andrew; Balmer, Vreni; Ortega-Mora, Luis Miguel; Álvarez-García, Gema (2018). Repurposing of commercially available anti-coccidials identifies diclazuril and decoquinate as potential therapeutic candidates against Besnoitia besnoiti infection. Veterinary parasitology, 261, pp. 77-85. Elsevier 10.1016/j.vetpar.2018.08.015
Olias, Philipp Alexander; Dettwiler, Ines Sarah; Hemphill, Andrew; Deplazes, P; Steiner, Adrian; Meylan, Mireille (2018). [The significance of cryptosporidiosis for the health of calves in Switzerland]. Schweizer Archiv für Tierheilkunde, 160(6), pp. 363-374. Gesellschaft Schweizer Tierärztinnen und Tierärzte 10.17236/sat00163
Joekel, Deborah E.; Lundström-Stadelmann, Britta; Müllhaupt, Beat; Hemphill, Andrew; Deplazes, Peter (2018). Evaluation of kinase-inhibitors nilotinib and everolimus against alveolar echinococcosis in vitro and in a mouse model. Experimental parasitology, 188, pp. 65-72. Elsevier 10.1016/j.exppara.2018.04.002
Dawoody Nejad, Ladan; Serricchio, Mauro; Jelk, Jennifer; Hemphill, Andrew; Bütikofer, Peter (2018). TbLpn, a key enzyme in lipid droplet formation and phospholipid metabolism, is essential for mitochondrial integrity and growth of Trypanosoma brucei. (In Press). Molecular microbiology Wiley 10.1111/mmi.13976
Sánchez-Sánchez, Roberto; Ferre, Ignacio; Re, Michela; Vázquez, Patricia; Ferrer, Luis Miguel; Blanco-Murcia, Javier; Regidor-Cerrillo, Javier; Pizarro Díaz, Manuel; González-Huecas, Marta; Tabanera, Enrique; García-Lunar, Paula; Benavides, Julio; Castaño, Pablo; Hemphill, Andrew; Hulverson, Matthew A; Whitman, Grant R; Rivas, Kasey L; Choi, Ryan; Ojo, Kayode K; Barrett, Lynn K; ... (2018). Safety and efficacy of the bumped kinase inhibitor BKI-1553 in pregnant sheep experimentally infected with Neospora caninum tachyzoites. International journal for parasitology. Drugs and drug resistance, 8(1), pp. 112-124. Elsevier 10.1016/j.ijpddr.2018.02.003
De Amorim Cardoso, Rita Isabel; Wang, Junhua; Müller, Joachim; Rupp, Sebastian Dominic Alexander; Leitão, Alexandre; Hemphill, Andrew (2018). Modulation of cis- and trans- Golgi and the Rab9A-GTPase during infection by Besnoitia besnoiti, Toxoplasma gondii and Neospora caninum. Experimental parasitology, 187, pp. 75-85. Elsevier 10.1016/j.exppara.2018.02.008
Rufener, Reto; Dick, Luca; D'Ascoli, Laura; Ritler, Dominic; Hizem, Amani; Wells, Timothy N.C.; Hemphill, Andrew; Lundström-Stadelmann, Britta (2018). Repurposing of an old drug: In vitro and in vivo efficacies of buparvaquone against Echinococcus multilocularis. International journal for parasitology. Drugs and drug resistance, 8(3), pp. 440-450. Elsevier 10.1016/j.ijpddr.2018.10.011
Rufener, Reto; Ritler, Dominic; Zielinski, Jana; Dick, Luca; da Silva, Emerson Teixeira; da Silva Araujo, Adriele; Joekel, Deborah Elisabeth; Czock, David; Göpfert, Christine; Moraes, Adriana Marques; de Souza, Marcus Vinicius Nora; Müller, Joachim; Mevissen, Meike; Hemphill, Andrew; Lundström-Stadelmann, Britta (2018). Activity of mefloquine and mefloquine derivatives against Echinococcus multilocularis. International journal for parasitology. Drugs and drug resistance, 8(2), pp. 331-340. Elsevier 10.1016/j.ijpddr.2018.06.004
Müller, Joachim; Hemphill, Andrew; Müller, Norbert (2018). Physiological aspects of nitro drug resistance in Giardia lamblia. International journal for parasitology. Drugs and drug resistance, 8(2), pp. 271-277. Elsevier 10.1016/j.ijpddr.2018.04.008
Harmse, Rozanne; Wong, Ho Ning; Smit, Frans J; Müller, Joachim; Hemphill, Andrew; N'Da, David D; Haynes, Richard K (2017). Activities of 11-Azaartemisinin and N-Sulfonyl Derivatives against Neospora caninum and Comparative Cytotoxicities. ChemMedChem, 12(24), pp. 2094-2098. Wiley-VCH 10.1002/cmdc.201700600
Hemphill, Andrew; Leitão, Alexandre; Ortega-Mora, Luis-Miguel; Cooke, Brian M (2017). ApiCOWplexa 2017 - 4th International Meeting on Apicomplexan Parasites in Farm Animals. International journal for parasitology, 47(12), pp. 697-699. Elsevier 10.1016/j.ijpara.2017.09.002
Aguado Martinez, Adriana; Basto, Afonso P; Leitão, Alexandre; Hemphill, Andrew (2017). Neospora caninum in non-pregnant and pregnant mouse models: cross-talk between infection and immunity. International journal for parasitology, 47(12), pp. 723-735. Elsevier 10.1016/j.ijpara.2017.09.001
Jiménez-Meléndez, Alejandro; Ojo, Kayode K; Wallace, Alexandra M; Smith, Tess R; Hemphill, Andrew; Balmer, Vreni; Regidor-Cerrillo, Javier; Ortega-Mora, Luis M; Hehl, Adrian B; Fan, Erkang; Maly, Dustin J; Van Voorhis, Wesley C; Álvarez-García, Gema (2017). In vitro efficacy of bumped kinase inhibitors against Besnoitia besnoiti tachyzoites. International journal for parasitology, 47(12), pp. 811-821. Elsevier 10.1016/j.ijpara.2017.08.005
Hulverson, Matthew A; Choi, Ryan; Arnold, Samuel L M; Schaefer, Deborah A; Hemphill, Andrew; McCloskey, Molly C; Betzer, Dana P; Müller, Joachim; Vidadala, Rama S R; Whitman, Grant R; Rivas, Kasey L; Barrett, Lynn K; Hackman, Robert C; Love, Melissa S; McNamara, Case W; Shaughnessy, Thomas K; Kondratiuk, Alison; Kurnick, Matthew; Banfor, Patricia N; Lynch, James J; ... (2017). Advances in bumped kinase inhibitors for human and animal therapy for cryptosporidiosis. International journal for parasitology, 47(12), pp. 753-763. Elsevier 10.1016/j.ijpara.2017.08.006
Müller, Joachim; Aguado Martinez, Adriana; Laleu, Benoît; Balmer, Vreni; Ritler, Dominic; Hemphill, Andrew (2017). In vitro screening of the open source Pathogen Box identifies novel compounds with profound activities against Neospora caninum. International journal for parasitology, 47(12), pp. 801-809. Elsevier 10.1016/j.ijpara.2017.06.002
Van Voorhis, Wesley C; Doggett, J Stone; Parsons, Marilyn; Hulverson, Matthew A; Choi, Ryan; Arnold, Samuel; Riggs, Michael W; Hemphill, Andrew; Howe, Daniel K; Mealey, Robert H; Lau, Audrey O T; Merritt, Ethan A; Maly, Dustin J; Fan, Erkang; Ojo, Kayode K (2017). Extended-spectrum antiprotozoal bumped kinase inhibitors: A review. Experimental parasitology, 180, pp. 71-83. Elsevier 10.1016/j.exppara.2017.01.001
Kunz, Stefan; Balmer, Vreni; Sterk, Geert Jan; Pollastri, Michael P; Leurs, Rob; Müller, Norbert; Hemphill, Andrew; Spycher, Cornelia (2017). The single cyclic nucleotide-specific phosphodiesterase of the intestinal parasite Giardia lamblia represents a potential drug target. PLoS neglected tropical diseases, 11(9), e0005891. Public Library of Science 10.1371/journal.pntd.0005891
Müller, Joachim; Aguado Martinez, Adriana; Ortega-Mora, Luis-Miguel; Moreno-Gonzalo, Javier; Ferre, Ignacio; Hulverson, Matthew A; Choi, Ryan; McCloskey, Molly C; Barrett, Lynn K; Maly, Dustin J; Ojo, Kayode K; Van Voorhis, Wes; Hemphill, Andrew (2017). Development of a murine vertical transmission model for Toxoplasma gondii oocyst infection and studies on the efficacy of bumped kinase inhibitor (BKI)-1294 and the naphthoquinone buparvaquone against congenital toxoplasmosis. Journal of antimicrobial chemotherapy, 72(8), pp. 2334-2341. Oxford University Press 10.1093/jac/dkx134
Silva Pinto Basto, Afonso; Müller, Joachim; Rubbiani, Riccardo; Stibal, David; Giannini, Federico; Süss-Fink, Georg; Balmer, Vreni; Hemphill, Andrew; Gasser, Gilles; Furrer, Julien (2017). Characterization of the Activities of Dinuclear Thiolato-Bridged Arene Ruthenium Complexes against Toxoplasma gondii. Antimicrobial agents and chemotherapy, 61(9), e01031-17. American Society for Microbiology 10.1128/AAC.01031-17
Müller, Joachim; Aguado Martinez, Adriana; Balmer, Vreni; Maly, Dustin J; Fan, Erkang; Ortega-Mora, Luis-Miguel; Ojo, Kayode K; Van Voorhis, Wesley C; Hemphill, Andrew (2017). Two novel calcium-dependent kinase 1-inhibitors interfere with vertical transmission in mice infected with Neospora caninum tachyzoites. Antimicrobial agents and chemotherapy, 61(4) American Society for Microbiology 10.1128/AAC.02324-16
Ruppen, Corinne; Hemphill, Andrew; Sendi, Parham (2017). In vitro activity of gentamicin as an adjunct to penicillin against biofilm group B Streptococcus. Journal of antimicrobial chemotherapy, 72(2), pp. 444-447. Oxford University Press 10.1093/jac/dkw447
Ritler, Dominic; Rufener, Reto; Sager, Heinz; Bouvier, Jacques; Hemphill, Andrew; Lundström-Stadelmann, Britta (2017). Development of a movement-based in vitro screening assay for the identification of new anti-cestodal compounds. PLoS neglected tropical diseases, 11(5), e0005618. Public Library of Science 10.1371/journal.pntd.0005618
Gorgas, Daniela; Marreros Canales, Nelson Antonio; Rufener, Reto; Hemphill, Andrew; Lundström-Stadelmann, Britta (2017). To see or not to see: non-invasive imaging for improved readout of drug treatment trials in the murine model of secondary alveolar echinococcosis. Parasitology, 144(07), pp. 937-944. Cambridge University Press 10.1017/S0031182017000051
Leineweber, Margret; Spekker-Bosker, Katrin; Ince, Vanessa; Schares, Gereon; Hemphill, Andrew; Eller, Silvia K; Däubener, Walter (2017). First Characterization of the Neospora caninum Dense Granule Protein GRA9. BioMed research international, 2017, p. 6746437. Hindawi Publishing Corporation 10.1155/2017/6746437
Dubey, Jitender; Hemphill, Andrew; Calero-Bernal, Rafael; Schares, Gereon (2017). Neosporosis in animals [Textbook] . Boca Raton, FL: CRC Press
Horcajo, P; Regidor-Cerrillo, J; Aguado Martinez, Adriana; Hemphill, Andrew; Ortega-Mora, L M (2016). Vaccines for bovine neosporosis: current status and key aspects for development. Parasite immunology, 38(12), pp. 709-723. Wiley 10.1111/pim.12342
Silva, Luciana Damacena; Arrúa, Eva Carolina; Pereira, Dayanne Amaral; Fraga, Carolina Miguel; Costa, Tatiane Luiza da; Hemphill, Andrew; Salomon, Claudio Javier; Vinaud, Marina Clare (2016). Elucidating the influence of praziquantel nanosuspensions on the in vivo metabolism of Taenia crassiceps cysticerci. Acta tropica, 161, pp. 100-105. Elsevier 10.1016/j.actatropica.2016.06.002
Müller, Joachim; Hemphill, Andrew (2016). Drug target identification in protozoan parasites. Expert opinion on drug discovery, 11(8), pp. 815-824. Taylor & Francis 10.1080/17460441.2016.1195945
Van Voorhis, Wesley C; Adams, John H; Adelfio, Roberto; Ahyong, Vida; Akabas, Myles H; Alano, Pietro; Alday, Aintzane; Alemán Resto, Yesmalie; Alsibaee, Aishah; Alzualde, Ainhoa; Andrews, Katherine T; Avery, Simon V; Avery, Vicky M; Ayong, Lawrence; Baker, Mark; Baker, Stephen; Ben Mamoun, Choukri; Bhatia, Sangeeta; Bickle, Quentin; Bounaadja, Lotfi; ... (2016). Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond. PLoS pathogens, 12(7), e1005763. Public Library of Science 10.1371/journal.ppat.1005763
De Amorim Cardoso, Rita Isabel; Soares, Helena; Hemphill, Andrew; Leitão, Alexandre (2016). Apicomplexans pulling the strings: manipulation of the host cell cytoskeleton dynamics. Parasitology, 143(8), pp. 957-970. Cambridge University Press 10.1017/S0031182016000524
Pastor-Fernández, Iván; Regidor-Cerrillo, Javier; Álvarez-García, Gema; Marugán-Hernández, Virginia; García-Lunar, Paula; Hemphill, Andrew; Ortega-Mora, Luis M (2016). The tandemly repeated NTPase (NTPDase) from Neospora caninum is a canonical dense granule protein whose RNA expression, protein secretion and phosphorylation coincides with the tachyzoite egress. Parasites & Vectors, 9(1), p. 352. BioMed Central 10.1186/s13071-016-1620-4
Hostettler, Isabel; Müller, Joachim; Hemphill, Andrew (2016). In Vitro Screening of the Open-Source Medicines for Malaria Venture Malaria Box Reveals Novel Compounds with Profound Activities against Theileria annulata Schizonts. Antimicrobial agents and chemotherapy, 60(6), pp. 3301-3308. American Society for Microbiology 10.1128/AAC.02801-15
Imhof, Simon; Fragoso, Cristina; Hemphill, Andrew; Von Schubert, Conrad; Li, Dong; Legant, Wesley; Betzig, Erik; Roditi, Isabel (2016). Flagellar membrane fusion and protein exchange in trypanosomes; a new form of cell-cell communication? F1000Research, 5(682), p. 682. F1000 Research Ltd 10.12688/f1000research.8249.1
Aguado Martinez, Adriana; Silva Pinto Basto, Afonso; Müller, Joachim; Balmer, Vreni; Manser, Vera; Leitão, Alexandre; Hemphill, Andrew (2016). N-terminal fusion of a toll-like receptor 2-ligand to a Neospora caninum chimeric antigen efficiently modifies the properties of the specific immune response. Parasitology, 143(5), pp. 606-616. Cambridge University Press 10.1017/S0031182016000056
Lundström-Stadelmann, Britta; Rufener, Reto; Aeschbacher, Denise; Spiliotis, Markus; Gottstein, Bruno; Hemphill, Andrew (2016). Screening of the Open Source Malaria Box Reveals an Early Lead Compound for the Treatment of Alveolar Echinococcosis. PLoS neglected tropical diseases, 10(3), e0004535. Public Library of Science 10.1371/journal.pntd.0004535
Hemphill, Andrew; Aguado Martinez, Adriana; Müller, Joachim (2016). Approaches for the vaccination and treatment of Neospora caninum infections in mice and ruminant models. Parasitology, 143(3), pp. 245-259. Cambridge University Press 10.1017/S0031182015001596
Pastor-Fernández, Iván; Regidor-Cerrillo, Javier; Jiménez-Ruiz, Elena; Álvarez-García, Gema; Marugán-Hernández, Virginia; Hemphill, Andrew; Ortega-Mora, Luis M (2016). Characterization of the Neospora caninum NcROP40 and NcROP2Fam-1 rhoptry proteins during the tachyzoite lytic cycle. Parasitology, 143(1), pp. 97-113. Cambridge University Press 10.1017/S0031182015001511
Arranz-Solis, David; Benavides, Julio; Regidor-Cerrillo, Javier; Horcajo, Pilar; Castaño, Pablo; del Carmen Ferreras, María; Jiménez-Pelayo, Laura; Collantes-Fernández, Esther; Ferre, Ignacio; Hemphill, Andrew; Pérez, Valentín; Ortega-Mora, Luis Miguel (2016). Systemic and local immune responses in sheep after Neospora caninum experimental infection at early, mid and late gestation. Veterinary research, 47, p. 2. BioMed Central 10.1186/s13567-015-0290-0
Müller, Joachim; Aguado Martinez, Adriana; Manser, Vera; Wong, Ho Ning; Haynes, Richard K; Hemphill, Andrew (2016). Repurposing of antiparasitic drugs: the hydroxy-naphthoquinone buparvaquone inhibits vertical transmission in the pregnant neosporosis mouse model. Veterinary research, 47, p. 32. BioMed Central 10.1186/s13567-016-0317-1
Fadda, Angela; Bärtschi, Michelle; Hemphill, Andrew; Widmer, Hans Rudolf; Zurbriggen, Andreas; Perona, P; Vidondo Curras, Beatriz; Oevermann, Anna (2016). Primary Postnatal Dorsal Root Ganglion Culture from Conventionally Slaughtered Calves. PLoS ONE, 11(12), e0168228. Public Library of Science 10.1371/journal.pone.0168228
Küster, Tatiana; Lundström-Stadelmann, Britta; Rufener, Reto; Risch, Corina; Müller, Joachim; Hemphill, Andrew (2015). Oral treatments of Echinococcus multilocularis-infected mice with the antimalarial drug mefloquine that potentially interacts with parasite ferritin and cystatin. International journal of antimicrobial agents, 46(5), pp. 546-551. Elsevier 10.1016/j.ijantimicag.2015.07.016
Gottstein, Bruno; Wang, Junhua; Boubaker, Ghalia; Marinova, Irina; Spiliotis, Markus; Müller, Norbert; Hemphill, Andrew (2015). Susceptibility versus resistance in alveolar echinococcosis (larval infection with Echinococcus multilocularis). Veterinary parasitology, 213(3-4), pp. 103-109. Elsevier 10.1016/j.vetpar.2015.07.029
Winzer, Pablo Arnold; Müller, Joachim; Aguado Martinez, Adriana; Rahman, Mahbubur; Balmer, Vreni; Manser, Vera; Ortega-Mora, Luis Miguel; Ojo, Kayode K; Fan, Erkang; Maly, Dustin J; Van Voorhis, Wesley C; Hemphill, Andrew (2015). In Vitro and In Vivo Effects of the Bumped Kinase Inhibitor 1294 in the Related Cyst-Forming Apicomplexans Toxoplasma gondii and Neospora caninum. Antimicrobial agents and chemotherapy, 59(10), pp. 6361-6374. American Society for Microbiology 10.1128/AAC.01236-15
Arranz Solis, David; Aguado Martinez, Adriana; Müller, Joachim; Regidor-Cerrillo, Javier; Ortega-Mora, Luis Miguel; Hemphill, Andrew (2015). Dose-dependent effects of experimental infection with the virulent Neospora caninum Nc-Spain7 isolate in a pregnant mouse model. Veterinary parasitology, 211(3-4), pp. 133-140. Elsevier 10.1016/j.vetpar.2015.05.021
Müller, Joachim; Balmer, Vreni; Winzer, Pablo Arnold; Rahman, Mahbubur; Manser, Vera; Haynes, Richard K; Hemphill, Andrew (2015). In vitro effects of new artemisinin derivatives in Neospora caninum-infected human fibroblasts. International journal of antimicrobial agents, 46(1), pp. 88-93. Elsevier 10.1016/j.ijantimicag.2015.02.020
Boubaker, Ghalia; Hemphill, Andrew; Huber, Cristina Olivia; Spiliotis, Markus; Babba, Hamouda; Gottstein, Bruno (2015). Prevention and Immunotherapy of Secondary Murine Alveolar Echinococcosis Employing Recombinant EmP29 Antigen. PLoS neglected tropical diseases, 9(6), e0003795. Public Library of Science 10.1371/journal.pntd.0003795
Wang, Junhua; Vuitton, Dominique A; Müller, Norbert; Hemphill, Andrew; Spiliotis, Markus; Blagosklonov, Oleg; Grandgirard, Denis; Leib, Stephen; Shalev, Itay; Levy, Gary; Lu, Xiaomei; Lin, Renyong; Wen, Hao; Gottstein, Bruno (2015). Deletion of Fibrinogen-like Protein 2 (FGL-2), a Novel CD4+ CD25+ Treg Effector Molecule, Leads to Improved Control of Echinococcus multilocularis Infection in Mice. PLoS neglected tropical diseases, 9(5), e0003755. Public Library of Science 10.1371/journal.pntd.0003755
Müller, Joachim; Aguado Martinez, Adriana; Manser, Vera; Balmer, Vreni; Winzer, Pablo Arnold; Ritler, Dominic; Hostettler, Isabel; Arranz Solis, David; Ortega-Mora, Luis; Hemphill, Andrew (2015). Buparvaquone is active against Neospora caninum in vitro and in experimentally infected mice. International journal for parasitology. Drugs and drug resistance, 5(1), pp. 16-25. Elsevier 10.1016/j.ijpddr.2015.02.001
Reichel, Michael P; Moore, Dadín P; Hemphill, Andrew; Ortega-Mora, Luis M; Dubey, J P; Ellis, John T (2015). A live vaccine against Neospora caninum abortions in cattle. Vaccine, 33(11), pp. 1299-1301. Elsevier 10.1016/j.vaccine.2015.01.064
Arranz Solis, David; Benavides, Julio; Regidor-Cerrillo, Javier; Fuertes, Miguel; Ferre, Ignacio; Ferreras, Maria Del Carmen; Collantes-Fernández, Esther; Hemphill, Andrew; Pérez, Valentín; Ortega-Mora, Luis Miguel (2015). Influence of the gestational stage on the clinical course, lesional development and parasite distribution in experimental ovine neosporosis. Veterinary research, 46, p. 19. Editions scientifiques Elsevier 10.1186/s13567-014-0139-y
Pastor-Fernández, Iván; Arranz-Solís, David; Regidor-Cerrillo, Javier; Álvarez-García, Gema; Hemphill, Andrew; García-Culebras, Alicia; Cuevas-Martín, Carmen; Ortega-Mora, Luis M (2015). A vaccine formulation combining rhoptry proteins NcROP40 and NcROP2 improves pup survival in a pregnant mouse model of neosporosis. Veterinary parasitology, 207(3-4), pp. 203-215. Elsevier 10.1016/j.vetpar.2014.12.009
Naguleswaran, Arunasalam; Gunasekera, Kapila; Schimanski, Bernd; Heller, Manfred; Hemphill, Andrew; Ochsenreiter, Torsten; Roditi, Isabel (2015). Trypanosoma brucei RRM1 is a nuclear RNA-binding protein and modulator of chromatin structure. mBio, 6(2), e00114. American Society for Microbiology 10.1128/mBio.00114-15
Hostettler, Isabel; Müller, Joachim; Stephens, Chad E; Haynes, Richard; Hemphill, Andrew (2014). A quantitative reverse-transcriptase PCR assay for the assessment of drug activities against intracellular Theileria annulata schizonts. International journal for parasitology. Drugs and drug resistance, 4(3), pp. 201-209. Elsevier 10.1016/j.ijpddr.2014.09.003
Lundström-Stadelmann, Britta; Aeschbacher, Denise; Huber, Cristina; Spiliotis, Markus; Müller, Joachim; Hemphill, Andrew (2014). Profound activity of the anti-cancer drug bortezomib against Echinococcus multilocularis metacestodes identifies the proteasome as a novel drug target for cestodes. PLoS neglected tropical diseases, 8(12), e3352. Public Library of Science 10.1371/journal.pntd.0003352
Boubaker, Ghalia; Gottstein, Bruno; Hemphill, Andrew; Babba, Hamouda; Spiliotis, Markus (2014). Echinococcus P29 antigen: molecular characterization and implication on post-surgery follow-up of CE patients infected with different species of the Echinococcus granulosus complex. PLoS ONE, 9(5), e98357. Public Library of Science 10.1371/journal.pone.0098357
Monney, Thierry; Hemphill, Andrew (2014). Vaccines against neosporosis: what can we learn from the past studies? Experimental parasitology, 140, pp. 52-70. Elsevier 10.1016/j.exppara.2014.02.015
Küster, Tatiana; Lundström-Stadelmann, Britta; Aeschbacher, Denise; Hemphill, Andrew (2014). Activities of fenbendazole in comparison with albendazole against Echinococcus multilocularis metacestodes in vitro and in a murine infection model. International journal of antimicrobial agents, 43(4), pp. 335-342. Elsevier 10.1016/j.ijantimicag.2014.01.013
Küster, Tatiana; Kriegel, Nadja; Lundström-Stadelmann, Britta; Wang, Xiaofang; Dong, Yuxiang; Vennerstrom, Jonathan L; Keiser, Jennifer; Hemphill, Andrew (2014). Amino ozonides exhibit in vitro activity against Echinococcus multilocularis metacestodes. International journal of antimicrobial agents, 43(1), pp. 40-46. Elsevier 10.1016/j.ijantimicag.2013.09.012
Hemphill, Andrew; Lundström-Stadelmann, Britta; Rufener, Reto; Spiliotis, Markus; Boubaker, Ghalia; Müller, Joachim; Müller, Norbert; Gorgas, Daniela; Gottstein, Bruno (2014). Treatment of echinococcosis: albendazole and mebendazole - what else? Parasite, 21, p. 70. Princeps Editions 10.1051/parasite/2014073
Cortes, Helder; Leitão, Alexandre; Gottstein, Bruno; Hemphill, Andrew (2014). A review on bovine besnoitiosis: a disease with economic impact in herd health management, caused by Besnoitia besnoiti (Franco and Borges, 1916). Parasitology, 141(11), pp. 1406-1417. Cambridge University Press 10.1017/S0031182014000262
Hemphill, Andrew; Leitão, Alexandre (2014). ApiCOWplexa 2013--2nd International Meeting on Apicomplexan Parasites in Farm Animals. Parasitology, 141(11), pp. 1355-1358. Cambridge University Press 10.1017/S0031182014001164
Ojo, Kayode K; Reid, Molly C; Kallur Siddaramaiah, Latha; Müller, Joachim; Winzer, Pablo Arnold; Zhang, Zhongsheng; Keyloun, Katelyn R; Vidadala, Rama Subba Rao; Merritt, Ethan A; Hol, Wim G J; Maly, Dustin J; Fan, Erkang; Van Voorhis, Wesley C; Hemphill, Andrew (2014). Neospora caninum calcium-dependent protein kinase 1 is an effective drug target for neosporosis therapy. PLoS ONE, 9(3), e92929. Public Library of Science 10.1371/journal.pone.0092929
Hemer, Sarah; Konrad, Christian; Spiliotis, Markus; Koziol, Uriel; Schaack, Dominik; Förster, Sabine; Gelmedin, Verena; Lundström-Stadelmann, Britta; Dandekar, Thomas; Hemphill, Andrew; Brehm, Klaus (2014). Host insulin stimulates Echinococcus multilocularis insulin signalling pathways and larval development. BMC biology, 12, p. 5. BioMed Central 10.1186/1741-7007-12-5
Barna, Fabienne; Debache, Karim; Vock, Carsten A.; Küster, Tatiana; Hemphill, Andrew (2013). In vitro effects of novel ruthenium complexes in Neospora caninum and Toxoplasma gondii tachyzoites. Antimicrobial agents and chemotherapy, 57(11), pp. 5747-5754. American Society for Microbiology 10.1128/AAC.02446-12
Küster, Tatiana; Kriegel, Nadja; Boykin, David W.; Stephens, Chad E.; Hemphill, Andrew (2013). In vitro and in vivo activities of dicationic diguanidino compounds against Echinococcus multilocularis metacestodes. Antimicrobial agents and chemotherapy, 57(8), pp. 3829-3835. American Society for Microbiology 10.1128/AAC.02569-12
Spekker, K.; Leineweber, M.; Degrandi, D.; Ince, V.; Brunder, S.; Schmidt, S. K.; Stuhlsatz, S.; Howard, J. C.; Schares, G.; Degistirici, O.; Meisel, R.; Sorg, R. V.; Seissler, J.; Hemphill, Andrew; Pfeffer, K.; Däubener, W. (2013). Antimicrobial effects of murine mesenchymal stromal cells directed against Toxoplasma gondii and Neospora caninum: role of immunity-related GTPases (IRGs) and guanylate-binding proteins (GBPs). Medical microbiology and immunology, 202(3), pp. 197-206. Springer 10.1007/s00430-012-0281-y
Hemphill, Andrew; Debache, Karim; Monney, Thierry; Schorer, Michelle; Gouinaud, Christophe; Alaeddine, Ferial; Müller, Norbert; Müller, Joachim (2013). Proteins mediating the Neospora caninum-host cell interaction as targets for vaccination. Frontiers in Bioscience (Elite Edition), 5, pp. 23-36. Frontiers in Bioscience
Debache, Karim; Hemphill, Andrew (2013). Differential effects of intranasal vaccination with recombinant NcPDI in different mouse models of Neospora caninum infection. Parasite immunology, 35(1), pp. 11-20. Blackwell Scientific Publications 10.1111/pim.12013
Alaeddine, Ferial; Hemphill, Andrew; Debache, Karim; Guionaud, Christophe (2013). Molecular cloning and characterization of NcROP2Fam-1, a member of the ROP2 family of rhoptry proteins in Neospora caninum that is targeted by antibodies neutralizing host cell invasion in vitro. Parasitology, 140(8), pp. 1033-1050. Cambridge University Press 10.1017/S0031182013000383
Küster, Tatiana; Hermann, Corina; Hemphill, Andrew; Gottstein, Bruno; Spiliotis, Markus (2013). Subcutaneous infection model facilitates treatment assessment of secondary Alveolar echinococcosis in mice. PLoS neglected tropical diseases, 7(5), e2235. Public Library of Science 10.1371/journal.pntd.0002235
Mols-Vorstermans, Tanja; Hemphill, Andrew; Monney, Thierry; Schaap, Dick; Boerhout, Eveline (2013). Differential Effects on Survival, Humoral Immune Responses and Brain Lesions in Inbred BALB/C, CBA/CA, and C57BL/6 Mice Experimentally Infected with Neospora caninum Tachyzoites. ISRN Parasitology, 2013, pp. 1-11. Hindawi 10.5402/2013/830980
Monney, Thierry; Grandgirard, Denis; Leib, Stephen; Hemphill, Andrew (2013). Use of a Th1 Stimulator Adjuvant for Vaccination against Neospora caninum Infection in the Pregnant Mouse Model. Pathogens, 2(2), pp. 193-208. MDPI AG 10.3390/pathogens2020193
Hemphill, Andrew; Müller, Norbert; Müller, Joachim (2013). Thiazolides, a Novel Class of Anti-Infective Drugs, Effective Against Viruses, Bacteria, Intracellular and Extracellular Protozoan Parasites and Proliferating Mammalian Cells. Anti-infective agents in medicinal chemistry, 11(1), pp. 22-30. Bentham Science 10.2174/22113626130103
Zysset-Burri, Denise Corinne; Gottstein, Bruno; Zumkehr, Béatrice; Hemphill, Andrew; Schürch, Nadia; Wittwer, Matthias; Müller, Norbert (2012). Development of a high- versus low-pathogenicity model of the free-living amoeba Naegleria fowleri. Microbiology, 158(Pt 10), pp. 2652-2660. Society for General Microbiology 10.1099/mic.0.059790-0
Küster, Tatiana; Zumkehr, Beatrice; Hermann, Corina; Theurillat, Regula; Thormann, Wolfgang; Gottstein, Bruno; Hemphill, Andrew (2012). Voluntary ingestion of antiparasitic drugs emulsified in honey represents an alternative to gavage in mice. American Association for Laboratory Animal Science Journal, 51(2), pp. 219-223. American Association for Laboratory Animal Science
Sidler, D; Brockmann, A; Mueller, J; Nachbur, U; Corazza, N; Renzulli, P; Hemphill, A; Brunner, T (2012). Thiazolide-induced apoptosis in colorectal cancer cells is mediated via the Jun kinase-Bim axis and reveals glutathione-S-transferase P1 as Achilles' heel. Oncogene, 31(37), pp. 4095-106. Basingstoke, UK: Nature Publishing Group 10.1038/onc.2011.575
Kropf, C; Debache, K; Rampa, C; Barna, F; Schorer, M; Stephens, C E; Ismail, M A; Boykin, D W; Hemphill, A (2012). The adaptive potential of a survival artist: characterization of the in vitro interactions of Toxoplasma gondii tachyzoites with di-cationic compounds in human fibroblast cell cultures. Parasitology, 139(2), pp. 208-20. London: Cambridge University Press 10.1017/S0031182011001776
Monney, Thierry; Rütti, David; Schorer, Michelle; Debache, Karim; Grandgirard, Denis; Leib, Stephen L.; Hemphill, Andrew (2011). RecNcMIC3-1-R is a microneme- and rhoptry-based chimeric antigen that protects against acute neosporosis and limits cerebral parasite load in the mouse model for Neospora caninum infection. Vaccine, 29(40), pp. 6967-6975. Amsterdam: Elsevier 10.1016/j.vaccine.2011.07.038
Cortes, H.C.; Muller, N.; Boykin, D.; Stephens, C.E.; Hemphill, A. (2011). In vitro effects of arylimidamides against Besnoitia besnoiti infection in Vero cells. Parasitology, 138(5), pp. 583-92. London: Cambridge University Press 10.1017/S0031182011000114
Debache, K.; Guionaud, C.; Kropf, C.; Boykin, D.; Stephens, C.E.; Hemphill, A. (2011). Experimental treatment of Neospora caninum-infected mice with the arylimidamide DB750 and the thiazolide nitazoxanide. Experimental parasitology, 129(2), pp. 95-100. Amsterdam: Elsevier 10.1016/j.exppara.2011.07.010
Debache, K.; Kropf, C.; Schutz, C.A.; Harwood, L.J.; Kauper, P.; Monney, T.; Rossi, N.; Laue, C.; McCullough, K.C.; Hemphill, A. (2011). Vaccination of mice with chitosan nanogel-associated recombinant NcPDI against challenge infection with Neospora caninum tachyzoites. Parasite immunology, 33(2), pp. 81-94. Oxford: Blackwell Scientific Publications 10.1111/j.1365-3024.2010.01255.x
Kuster, T.; Lundström-Stadelmann, Britta; Hermann, C.; Scholl, S.; Keiser, J.; Hemphill, A. (2011). In vitro and in vivo efficacies of mefloquine-based treatment against alveolar echinococcosis. Antimicrobial agents and chemotherapy, 55(2), pp. 713-21. Washington, D.C.: American Society for Microbiology 10.1128/AAC.01392-10
Marcelino, E.; Martins, T.M.; Morais, J.B.; Nolasco, S.; Cortes, H.; Hemphill, A.; Leitao, A.; Novo, C. (2011). Besnoitia besnoiti protein disulfide isomerase (BbPDI): molecular characterization, expression and in silico modelling. Experimental parasitology, 129(2), pp. 164-74. Amsterdam: Elsevier 10.1016/j.exppara.2011.06.012
Marugan-Hernandez, V.; Alvarez-Garcia, G.; Tomley, F.; Hemphill, A.; Regidor-Cerrillo, J.; Ortega-Mora, L.M. (2011). Identification of novel rhoptry proteins in Neospora caninum by LC/MS-MS analysis of subcellular fractions. Journal of proteomics, 74(5), pp. 629-42. Amsterdam: Elsevier 10.1016/j.jprot.2011.02.004
Mejri, N.; Muller, N.; Hemphill, A.; Gottstein, B. (2011). Intraperitoneal Echinococcus multilocularis infection in mice modulates peritoneal CD4+ and CD8+ regulatory T cell development. Parasitology international, 60(1), pp. 45-53. Amsterdam: Elsevier 10.1016/j.parint.2010.10.002
Müller, J.; Müller, N.; Hemphill, A. (2011). Drugs and drug targets in Neospora caninum and related apicomplexans. In: Becker, Katja (ed.) Apicomplexan Parasites. Drug discovery in Infectious Diseases: Vol. 2 (pp. 359-371). Chichester: John Wiley & Sons
Müller, J.; Hemphill, A.; Müller, N. (2011). Treatment of giardiasis and drug resistance. In: Lujan, Hugo D.; Svärd, Staffan (eds.) Giardia - a model organism. Heidelberg: Springer Verlag
Muller, J.; Hemphill, A. (2011). Identification of a host cell target for the thiazolide class of broad-spectrum anti-parasitic drugs. Experimental parasitology, 128(2), pp. 145-50. Amsterdam: Elsevier 10.1016/j.exppara.2011.02.007
Muller, J.; Hemphill, A. (2011). Drug target identification in intracellular and extracellular protozoan parasites. Current topics in medicinal chemistry, 11(16), pp. 2029-38. Hilversum: Bentham Science Publishers 10.2174/156802611796575876
Pohle, S.; Ernst, R.; MacKenzie, C.; Spicher, M.; Romig, T.; Hemphill, A.; Gripp, S. (2011). Echinococcus multilocularis: the impact of ionizing radiation on metacestodes. Experimental parasitology, 127(1), pp. 127-34. Amsterdam: Elsevier 10.1016/j.exppara.2010.07.006
Lundström-Stadelmann, Britta; Kuster, T.; Scholl, S.; Barna, F.; Kropf, C.; Keiser, J.; Boykin, D.W.; Stephens, C.E.; Hemphill, A. (2011). In vitro efficacy of dicationic compounds and mefloquine enantiomers against Echinococcus multilocularis metacestodes. Antimicrobial agents and chemotherapy, 55(10), pp. 4866-72. Washington, D.C.: American Society for Microbiology 10.1128/AAC.00478-11
Pachlatko, E.; Rusch, S.; Müller, A.; Hemphill, A.; Tilley, L.; Hanssen, E.; Beck, H.P. (2010). MAHRP2, an exported protein of Plasmodium falciparum, is an essential component of Maurer's cleft tethers. Molecular microbiology, 77(5), pp. 1136-1152. Oxford: Blackwell Science 10.1111/j.1365-2958.2010.07278.x
Debache, K.; Guionaud, C.; Alaeddine, F.; Hemphill, A. (2010). Intraperitoneal and intra-nasal vaccination of mice with three distinct recombinant Neospora caninum antigens results in differential effects with regard to protection against experimental challenge with Neospora caninum tachyzoites. Parasitology, 137(2), pp. 229-40. London: Cambridge University Press 10.1017/S0031182009991259
Guionaud, C.; Hemphill, A.; Mevissen, M.; Alaeddine, F. (2010). Molecular characterization of Neospora caninum MAG1, a dense granule protein secreted into the parasitophorous vacuole, and associated with the cyst wall and the cyst matrix. Parasitology, 137(11), pp. 1605-19. London: Cambridge University Press 10.1017/S0031182010000442
Hemphill, A. (2010). Development and applications of cestode and trematode laboratory models. Parasitology, 137(3), pp. 329-33. London: Cambridge University Press 10.1017/S0031182010000132
Hemphill, A.; Stadelmann, B.; Scholl, S.; Muller, J.; Spiliotis, M.; Muller, N.; Gottstein, B.; Siles-Lucas, M. (2010). Echinococcus metacestodes as laboratory models for the screening of drugs against cestodes and trematodes. Parasitology, 137(3), pp. 569-87. London: Cambridge University Press 10.1017/S003118200999117X
Mejri, N.; Hemphill, A.; Gottstein, B. (2010). Triggering and modulation of the host-parasite interplay by Echinococcus multilocularis: a review. Parasitology, 137(3), pp. 557-68. London: Cambridge University Press 10.1017/S0031182009991533
Lundström-Stadelmann, Britta; Scholl, Sabrina; Muller, J.; Hemphill, A. (2010). Application of an in vitro drug screening assay based on the release of phosphoglucose isomerase to determine the structure-activity relationship of thiazolides against Echinococcus multilocularis metacestodes. Journal of antimicrobial chemotherapy, 65(3), pp. 512-9. Oxford: Oxford University Press 10.1093/jac/dkp490
Stadelmann, B.; Spiliotis, M.; Muller, J.; Scholl, S.; Muller, N.; Gottstein, B.; Hemphill, A. (2010). Echinococcus multilocularis phosphoglucose isomerase (EmPGI): a glycolytic enzyme involved in metacestode growth and parasite-host cell interactions. International journal for parasitology, 40(13), pp. 1563-74. Kidlington, UK: Elsevier 10.1016/j.ijpara.2010.05.009
Vassella, Erik; Oberle, Michael; Urwyler, Simon; Renggli, Christina Kunz; Studer, Erwin; Hemphill, Andrew; Fragoso, Cristina; Bütikofer, Peter; Brun, Reto; Roditi, Isabel (2009). Major surface glycoproteins of insect forms of Trypanosoma brucei are not essential for cyclical transmission by tsetse. PLoS ONE, 4(2), e4493. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0004493
Debache, Karim; Alaeddine, Ferial; Guionaud, Christophe; Monney, Thierry; Müller, Joachim; Strohbusch, Maria; Leib, Stephen L.; Grandgirard, Denis; Hemphill, Andrew (2009). Vaccination with recombinant NcROP2 combined with recombinant NcMIC1 and NcMIC3 reduces cerebral infection and vertical transmission in mice experimentally infected with Neospora caninum tachyzoites. International journal for parasitology, 39(12), pp. 1373-1384. Kidlington, UK: Elsevier 10.1016/j.ijpara.2009.04.006
Frey, Caroline; Schild, Marc; Hemphill, Andrew; Stünzi, Philipp; Müller, Norbert; Gottstein, Bruno; Burgener, Iwan (2009). Intestinal Tritrichomonas foetus infection in cats in Switzerland detected by in vitro cultivation and PCR. Parasitology research, 104(4), pp. 783-8. Berlin: Springer-Verlag 10.1007/s00436-008-1255-2
Hemphill, Andrew; Vonlaufen, Nathalie; Golaz, Julia L; Burgener, Iwan (2009). Infection of primary canine duodenal epithelial cell cultures with Neospora caninum. Journal of parasitology, 95(2), pp. 372-80. Lawrence, Kans.: American Society of Parasitologists 10.1645/GE-1812.1
Gris, P.; Tighe, A.; Thawer, S.; Hemphill, A.; Oatway, M.; Weaver, L.; Dekaban, G.A.; Brown, A. (2009). Gene expression profiling in anti-CD11d mAb-treated spinal cord-injured rats. Journal of neuroimmunology, 209(1-2), pp. 104-13. Amsterdam: Elsevier 10.1016/j.jneuroim.2009.02.002
Hemphill, A.; Muller, J. (2009). Alveolar and cystic echinococcosis: towards novel chemotherapeutical treatment options. Journal of helminthology, 83(2), pp. 99-111. Cambridge: Cambridge University Press 10.1017/S0022149X0928936X
Hemphill, A.W.; Akkari, Y.; Newell, A.H.; Schultz, R.A.; Grompe, M.; North, P.S.; Hickson, I.D.; Jakobs, P.M.; Rennie, S.; Pauw, D.; Hejna, J.; Olson, S.B.; Moses, R.E. (2009). Topo IIIalpha and BLM act within the Fanconi anemia pathway in response to DNA-crosslinking agents. Cytogenetic and genome research, 125(3), pp. 165-75. Basel: Karger 10.1159/000230001
Muller, J.; Limban, C.; Stadelmann, B.; Missir, A.V.; Chirita, I.C.; Chifiriuc, M.C.; Nitulescu, G.M.; Hemphill, A. (2009). Thioureides of 2-(phenoxymethyl)benzoic acid 4-R substituted: a novel class of anti-parasitic compounds. Parasitology international, 58(2), pp. 128-35. Amsterdam: Elsevier 10.1016/j.parint.2008.12.003
Müller, Joachim; Nillius, Dorothea; Hehl, A.; Hemphill, Andrew; Müller, Norbert (2009). Stable expression of Escherichia coli beta-glucuronidase A (GusA) in Giardia lamblia: application to high-throughput drug susceptibility testing. Journal of antimicrobial chemotherapy, 64(6), pp. 1187-1191. Oxford: Oxford University Press 10.1093/jac/dkp363
Schnyder, M.; Kohler, L.; Hemphill, A.; Deplazes, P. (2009). Prophylactic and therapeutic efficacy of nitazoxanide against Cryptosporidium parvum in experimentally challenged neonatal calves. Veterinary parasitology, 160(1-2), pp. 149-54. Amsterdam: Elsevier 10.1016/j.vetpar.2008.10.094
Strohbusch, M.; Muller, N.; Hemphill, A.; Krebber, R.; Greif, G.; Gottstein, B. (2009). Toltrazuril treatment of congenitally acquired Neospora caninum infection in newborn mice. Parasitology research, 104(6), pp. 1335-43. Berlin: Springer-Verlag 10.1007/s00436-009-1328-x
Strohbusch, M.; Muller, N.; Hemphill, A.; Margos, M.; Grandgirard, D.; Leib, Stephen; Greif, G.; Gottstein, B. (2009). Neospora caninum and bone marrow-derived dendritic cells: parasite survival, proliferation, and induction of cytokine expression. Parasite immunology, 31(7), pp. 366-372. Oxford: Blackwell Scientific Publications 10.1111/j.1365-3024.2009.01112.x
Gottstein, Bruno; Hemphill, Andrew (2008). Echinococcus multilocularis: the parasite-host interplay. Experimental parasitology, 119(4), pp. 447-452. Elsevier 10.1016/j.exppara.2008.03.002
Spicher, Martin; Naguleswaran, Arunasalam; Ortega-Mora, Luis M; Müller, Joachim; Gottstein, Bruno; Hemphill, Andrew (2008). In vitro and in vivo effects of 2-methoxyestradiol, either alone or combined with albendazole, against Echinococcus metacestodes. Experimental parasitology, 119(4), pp. 475-482. Elsevier 10.1016/j.exppara.2008.02.012
Müller, Joachim; Naguleswaran, Arunasalam; Müller, Norbert; Hemphill, Andrew (2008). Neospora caninum: functional inhibition of protein disulfide isomerase by the broad-spectrum anti-parasitic drug nitazoxanide and other thiazolides. Experimental parasitology, 118(1), pp. 80-8. Amsterdam: Elsevier 10.1016/j.exppara.2007.06.008
Spicher, Martin; Röthlisberger, Carole; Lany, C.; Lundström-Stadelmann, Britta; Keiser, J.; Ortega-Mora, L. M.; Gottstein, Bruno; Hemphill, Andrew (2008). In Vitro and In Vivo Treatments of Echinococcus Protoscoleces and Metacestodes with Artemisinin and Artemisinin Derivatives. Antimicrobial agents and chemotherapy, 52(9), pp. 3447-3450. American Society for Microbiology 10.1128/AAC.00553-08
Müller, Joachim; Ley, Serej; Felger, Ingrid; Hemphill, Andrew; Müller, Norbert (2008). Identification of differentially expressed genes in a Giardia lamblia WB C6 clone resistant to nitazoxanide and metronidazole. Journal of antimicrobial chemotherapy, 62(1), pp. 72-82. Oxford University Press 10.1093/jac/dkn142
Strohbusch, Maria; Müller, Norbert; Hemphill, Andrew; , ; Gottstein, Bruno (2008). NcGRA2 as a molecular target to assess the parasiticidal activity of toltrazuril against Neospora caninum. Parasitology, 135(9), pp. 1065-1073. Cambridge University Press 10.1017/S0031182008004599
Oberholzer, Michael; Marti, Gabriela; Baresic, Mario; Kunz, Stefan; Hemphill, Andrew; Seebeck, Thomas (2007). The Trypanosoma brucei cAMP phosphodiesterases TbrPDEB1 and TbrPDEB2: flagellar enzymes that are essential for parasite virulence. FASEB journal, 21(3), pp. 720-731. Bethesda, Md.: Federation of American Societies for Experimental Biology 10.1096/fj.06-6818com
Esposito, Marco; Müller, Norbert; Hemphill, Andrew (2007). Structure-activity relationships from in vitro efficacies of the thiazolide series against the intracellular apicomplexan protozoan Neospora caninum. International journal for parasitology, 37(2), pp. 183-90. Kidlington, UK: Elsevier 10.1016/j.ijpara.2006.10.009
Hemphill, A (2007). Response to Innes and Mattsson: Neospora caninum emerges from the shadow of Toxoplasma gondii. Trends in parasitology, 2(23), pp. 44-5. Oxford: Elsevier Current Trends 10.1016/j.pt.2006.12.007
Sterk, Maaike; Müller, Joachim; Hemphill, Andrew; Müller, Norbert (2007). Characterization of a Giardia lamblia WB C6 clone resistant to the isoflavone formononetin. Microbiology, 153(Pt 12), pp. 4150-8. Reading, UK: Society for General Microbiology 10.1099/mic.0.2007/010041-0
Arsenijevic, D; de Bilbao, F; Vallet, P; Hemphill, A; Gottstein, B; Richard, D; Giannakopoulos, P; Langhans, W (2007). Decreased infarct size after focal cerebral ischemia in mice chronically infected with Toxoplasma gondii. Neuroscience, 150(3), pp. 537-46. Oxford: Elsevier 10.1016/j.neuroscience.2007.09.080
Hemphill, Andrew; Spicher, Martin; Lundström-Stadelmann, Britta; Müller, Joachim; Naguleswaran, Arunasalam; Gottstein, Bruno; Walker, M (2007). Innovative chemotherapeutical treatment options for alveolar and cystic echinococcosis. Parasitology, 134(Pt 12), pp. 1657-70. London: Cambridge University Press 10.1017/S0031182007003198
Golaz, Julia L; Vonlaufen, Nathalie; Hemphill, Andrew; Burgener, Iwan A (2007). Establishment and characterization of a primary canine duodenal epithelial cell culture. In vitro cellular & developmental biology - animal, 43(5-6), pp. 176-85. Columbia, Md.: Springer-Verlag 10.1007/s11626-007-9034-4
Kaiser, Marcel; Wittlin, Sergio; Nehrbass-Stuedli, Angela; Dong, Yuxiang; Wang, Xiaofang; Hemphill, Andrew; Matile, Hugues; Brun, Reto; Vennerstrom, Jonathan L (2007). Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160). Antimicrobial agents and chemotherapy, 51(8), pp. 2991-3. Washington, D.C.: American Society for Microbiology 10.1128/AAC.00225-07
Müller, Joachim; Sterk, Maaike; Hemphill, Andrew; Müller, Norbert (2007). Characterization of Giardia lamblia WB C6 clones resistant to nitazoxanide and to metronidazole. Journal of antimicrobial chemotherapy, 60(2), pp. 280-7. Oxford: Oxford University Press 10.1093/jac/dkm205
Esposito, Marco; Moores, Shelley; Naguleswaran, Arunasalam; Müller, Joachim; Hemphill, Andrew (2007). Induction of tachyzoite egress from cells infected with the protozoan Neospora caninum by nitro- and bromo-thiazolides, a class of broad-spectrum anti-parasitic drugs. International journal for parasitology, 37(10), pp. 1143-52. Kidlington, UK: Elsevier 10.1016/j.ijpara.2007.03.007
Müller, Joachim; Wastling, Jonathan; Sanderson, Sanya; Müller, Norbert; Hemphill, Andrew (2007). A novel Giardia lamblia nitroreductase, GlNR1, interacts with nitazoxanide and other thiazolides. Antimicrobial agents and chemotherapy, 51(6), pp. 1979-86. Washington, D.C.: American Society for Microbiology 10.1128/AAC.01548-06
Cortes, Helder C E; Reis, Yara; Gottstein, Bruno; Hemphill, Andrew; Leitão, Alexandre; Müller, Norbert (2007). Application of conventional and real-time fluorescent ITS1 rDNA PCR for detection of Besnoitia besnoiti infections in bovine skin biopsies. Veterinary parasitology, 146(3-4), pp. 352-6. Amsterdam: Elsevier 10.1016/j.vetpar.2007.03.003
Risco-Castillo, V; Fernández-García, A; Zaballos, A; Aguado-Martínez, A; Hemphill, A; Rodríguez-Bertos, A; Alvarez-García, G; Ortega-Mora, L M (2007). Molecular characterisation of BSR4, a novel bradyzoite-specific gene from Neospora caninum. International journal for parasitology, 37(8-9), pp. 887-96. Kidlington, UK: Elsevier 10.1016/j.ijpara.2007.02.003
Cortes, H C E; Mueller, N; Esposito, M; Leitão, A; Naguleswaran, A; Hemphill, A (2007). In vitro efficacy of nitro- and bromo-thiazolyl-salicylamide compounds (thiazolides) against Besnoitia besnoiti infection in Vero cells. Parasitology, 134(Pt 7), pp. 975-85. London: Cambridge University Press 10.1017/S0031182007002417
Vonlaufen, N; Naguleswaran, A; Gianinazzi, C; Hemphill, A (2007). Characterization of the fetuin-binding fraction of Neospora caninum tachyzoites and its potential involvement in host-parasite interactions. Parasitology, 134(Pt 6), pp. 805-17. London: Cambridge University Press 10.1017/S0031182006002186
Srinivasan, Sangeetha; Mueller, Joachim; Suana, Angela; Hemphill, Andrew (2007). Vaccination with microneme protein NcMIC4 increases mortality in mice inoculated with Neospora caninum. Journal of parasitology, 93(5), pp. 1046-55. Lawrence, Kans.: American Society of Parasitologists 10.1645/GE-1181R1.1
Hemphill, A; Müller, N; Müller, J (2007). Structure-funktion relationship of thiazolides, a novel class of antiparasitic drugs, investigated in intracellular protozoan parasites and larvalstage cestodes. Anti-infective agents in medicinal chemistry(6), pp. 273-282. Sharjah: Bentham Science
Hemphill, A (2007). Generation of parasite cysts in cultured cells instead of living animals. Parasitology(24), pp. 29-31. London: Cambridge University Press
Naguleswaran, Arunasalam; Spicher, Martin; Vonlaufen, Nathalie; Ortega-Mora, Luis M; Torgerson, Paul; Gottstein, Bruno; Hemphill, Andrew (2006). In vitro metacestodicidal activities of genistein and other isoflavones against Echinococcus multilocularis and Echinococcus granulosus. Antimicrobial agents and chemotherapy, 50(11), pp. 3770-8. Washington, D.C.: American Society for Microbiology 10.1128/AAC.00578-06
Matsumoto, J; Müller, N; Hemphill, A; Oku, Y; Kamiya, M; Gottstein, B (2006). 14-3-3- and II/3-10-gene expression as molecular markers to address viability and growth activity of Echinococcus multilocularis metacestodes. Parasitology, 132(Pt 1), pp. 83-94. London: Cambridge University Press 10.1017/S0031182005008632
Srinivasan, Sangeetha; Baszler, Timothy; Vonlaufen, Nathalie; Leepin, Angela; Sanderson, Sanya J; Wastling, Jonathan M; Hemphill, Andrew (2006). Monoclonal antibody directed against Neospora caninum tachyzoite carbohydrate epitope reacts specifically with apical complex-associated sialylated beta tubulin. Journal of parasitology, 92(6), pp. 1235-43. Lawrence, Kans.: American Society of Parasitologists 10.1645/GE-889R.1
Cortes, H C E; Reis, Y; Waap, H; Vidal, R; Soares, H; Marques, I; Pereira da Fonseca, I; Fazendeiro, I; Ferreira, M L; Caeiro, V; Shkap, V; Hemphill, A; Leitão, A (2006). Isolation of Besnoitia besnoiti from infected cattle in Portugal. Veterinary parasitology, 141(3-4), pp. 226-33. Amsterdam: Elsevier 10.1016/j.vetpar.2006.05.022
Müller, Joachim; Rühle, Géraldine; Müller, Norbert; Rossignol, Jean-François; Hemphill, Andrew (2006). In vitro effects of thiazolides on Giardia lamblia WB clone C6 cultured axenically and in coculture with Caco2 cells. Antimicrobial agents and chemotherapy, 50(1), pp. 162-70. Washington, D.C.: American Society for Microbiology 10.1128/AAC.50.1.162-170.2006
Gottstein, Bruno; Haag, Karen; Walker, Mirjam; Matsumoto, Jun; Mejri, Naceur; Hemphill, Andrew (2006). Molecular survival strategies of Echinococcus multilocularis in the murine host. Parasitology international, 55 Suppl, S45-S49. Amsterdam: Elsevier 10.1016/j.parint.2005.11.006
Hemphill, Andrew; Mueller, Joachim; Esposito, Marco (2006). Nitazoxanide, a broad-spectrum thiazolide anti-infective agent for the treatment of gastrointestinal infections. Expert opinion on pharmacotherapy, 7(7), pp. 953-64. London: Informa Healthcare 10.1517/14656566.7.7.953
Hehl, A B; Hemphill, A (2006). The use of light- and electron microscopy for studies on the cell- and molecular biology of parasites and parasitic diseases. Schweizer Archiv für Tierheilkunde, 148(9), pp. 473-81. Bern: Huber 10.1024/0036-7281.148.9.473
Hemphill, A; Vonlaufen, N; Naguleswaran, A (2006). Cellular and immunological basis of the host-parasite relationship during infection with Neospora caninum. Parasitology, 133(Pt 3), pp. 261-78. London: Cambridge University Press 10.1017/S0031182006000485
Hemphill, A; Gottstein, B (2006). Neospora caninum and neosporosis - recent achievements in host and parasite cell biology and treatment. Acta parasitologica, 51(1), pp. 15-25. Warszawa: Versita 10.2478/s11686-006-0002-z
Scheidegger, Alexandra; Vonlaufen, Nathalie Françoise F.; Naguleswaran, Arunasalam; Gianinazzi, Christian; Müller, Norbert; Leib, Stephen; Hemphill, Andrew (2005). Differential effects of interferon-gamma and tumor necrosis factor-alpha on Toxoplasma gondii proliferation in organotypic rat brain slice cultures. Journal of parasitology, 91(2), pp. 307-315. American Society of Parasitologists 10.1645/GE-379R
von Allmen, N; Bienz, M; Hemphill, Andrew; Müller, Norbert (2005). Quantitative assessment of sense and antisense transcripts from genes involved in antigenic variation (vsp genes) and encystation (cwp 1 gene) of Giardia lamblia clone GS/M-83-H7. Parasitology, 130(Pt 4), pp. 389-396. Cambridge University Press
von Allmen, N; Bienz, M; Hemphill, Andrew; Müller, Norbert (2004). Experimental infections of neonatal mice with cysts of Giardia lamblia clone GS/M-83-H7 are associated with an antigenic reset of the parasite. Infection and immunity, 72(8), pp. 4763-4771. American Society for Microbiology 10.1128/IAI.72.8.4763-4771.2004
Stettler, Marianne; Rossignol, Jean François; Fink, Renate; Walker, Mirjam; Gottstein, Bruno; Merli, Michael; Theurillat, Regula; Thormann, Wolfgang; Dricot, Eric; Segers, Rudi; Hemphill, Andrew (2004). Secondary and primary murine alveolar echinococcosis: combined albendazole/nitazoxanide chemotherapy exhibits profound anti-parasitic activity. International journal for parasitology, 34(5), pp. 615-624. Elsevier 10.1016/j.ijpara.2004.01.006
Walker, Mirjam; Baz, Adriana; Dematteis, Sylvia; Stettler, Marianne; Gottstein, Bruno; Schaller, Johann; Hemphill, Andrew (2004). Isolation and characterization of a secretory component of Echinococcus multilocularis metacestodes potentially involved in modulating the host-parasite interface. Infection and immunity, 72(1), pp. 527-536. American Society for Microbiology
Walker, Mirjam; Rossignol, Jean François; Torgerson, Paul; Hemphill, Andrew (2004). In vitro effects of nitazoxanide on Echinococcus granulosus protoscoleces and metacestodes. Journal of antimicrobial chemotherapy, 54(3), pp. 609-616. Oxford University Press 10.1093/jac/dkh386
Cannas, A; Naguleswaran, A; Müller, Norbert; Eperon, S; Gottstein, Bruno; Hemphill, Andrew (2003). Vaccination of mice against experimental Neospora caninum infection using NcSAG1- and NcSRS2-based recombinant antigens and DNA vaccines. Parasitology, 126(04), pp. 303-312. Cambridge University Press
Stettler, Marianne; Fink, Renate; Walker, Mirjam; Gottstein, Bruno; Geary, Timothy G; Rossignol, Jean François; Hemphill, Andrew (2003). In vitro parasiticidal effect of Nitazoxanide against Echinococcus multilocularis metacestodes. Antimicrobial agents and chemotherapy, 47(2), pp. 467-474. American Society for Microbiology
Hemphill, Andrew; Stettler, Marianne; Walker, Mirjam; Siles-Lucas, Mar; Fink, Renate; Gottstein, Bruno (2003). In vitro culture of Echinococcus multilocularis and Echinococcus vogeli metacestodes: studies on the host-parasite interface. Acta tropica, 85(2), pp. 145-155. Elsevier
Cannas, Angela; Naguleswaran, Arunasalam; Müller, Norbert; Gottstein, Bruno; Hemphill, Andrew (2003). Reduced cerebral infection of Neospora caninum-infected mice after vaccination with recombinant microneme protein NcMIC3 and ribi adjuvant. Journal of parasitology, 89(1), pp. 44-50. American Society of Parasitologists 10.1645/0022-3395(2003)089[0044:RCIONC]2.0.CO;2
Hemphill, Andrew; Stettler, Marianne; Walker, Mirjam; Siles-Lucas, Mar; Fink, Renate; Gottstein, Bruno (2002). Culture of Echinococcus multilocularis metacestodes: an alternative to animal use. Trends in parasitology, 18(10), pp. 445-451. Elsevier Current Trends
Gottstein, Bruno; Dai, Wen Juan; Walker, Mirjam; Stettler, Marianne; Müller, Norbert; Hemphill, Andrew (2002). An intact laminated layer is important for the establishment of secondary Echinococcus multilocularis infection. Parasitology research, 88(9), pp. 822-828. Springer-Verlag 10.1007/s00436-002-0659-7
Dubey, J P; Barr, B C; Barta, J R; Bjerkås, I; Björkman, C; Blagburn, B L; Bowman, D D; Buxton, D; Ellis, J T; Gottstein, Bruno; Hemphill, Andrew; Hill, D E; Howe, D K; Jenkins, M C; Kobayashi, Y; Koudela, B; Marsh, A E; Mattsson, J G; McAllister, M M; Modrý, D; ... (2002). Redescription of Neospora caninum and its differentiation from related coccidia. International journal for parasitology, 32(8), pp. 929-946. Elsevier
Dai, W J; Hemphill, Andrew; Waldvogel, A; Ingold, K; Deplazes, P; Mossmann, H; Gottstein, Bruno (2001). Major carbohydrate antigen of Echinococcus multilocularis induces an immunoglobulin G response independent of alphabeta+ CD4+ T cells. Infection and immunity, 69(10), pp. 6074-6083. American Society for Microbiology 10.1128/IAI.69.10.6074-6083.2001
Müller, Norbert; Sager, Heinz; Hemphill, Andrew; Mehlhorn, H; Heydorn, A O; Gottstein, Bruno (2001). Comparative molecular investigation of Nc5-PCR amplicons from Neospora caninum NC-1 and Hammondia heydorni-Berlin-1996. Parasitology research, 87(10), pp. 883-885. Springer-Verlag
Stettler, M; Siles-Lucas, M; Sarciron, E; Lawton, P; Gottstein, Bruno; Hemphill, Andrew (2001). Echinococcus multilocularis alkaline phosphatase as a marker for metacestode damage induced by in vitro drug treatment with albendazole sulfoxide and albendazole sulfone. Antimicrobial agents and chemotherapy, 45(8), pp. 2256-2262. American Society for Microbiology 10.1128/AAC.45.8.2256-2262.2001
Ingold, K; Dai, W; Rausch, R L; Gottstein, Bruno; Hemphill, Andrew (2001). Characterization of the laminated layer of in vitro cultivated Echinococcus vogeli metacestodes. Journal of parasitology, 87(1), pp. 55-64. American Society of Parasitologists 10.1645/0022-3395(2001)087[0055:COTLLO]2.0.CO;2
Felleisen, R S; Hemphill, Andrew; Gottstein, Bruno (2001). A novel EF-hand calcium-binding protein in the flagellum of the protozoan Tritrichomonas suis. Parasitology, 122(02), pp. 125-132. Cambridge University Press
Hemphill, Andrew; Gottstein, Bruno (2000). A European perspective on Neospora caninum. International journal for parasitology, 30(8), pp. 877-924. Elsevier
Hemphill, Andrew; Müller, N; Sager, H; Gottstein, Bruno (2000). [Neospora caninum and neosporosis--basic science at the Institute of Parasitology and possible implications]. Schweizer Archiv für Tierheilkunde, 142(5), pp. 257-261. Huber
Sonda, S; Fuchs, N; Gottstein, Bruno; Hemphill, Andrew (2000). Molecular characterization of a novel microneme antigen in Neospora caninum. Molecular and biochemical parasitology, 108(1), pp. 39-51. Elsevier
Ingold, K; Gottstein, Bruno; Hemphill, Andrew (2000). High molecular mass glycans are major structural elements associated with the laminated layer of in vitro cultivated Echinococcus multilocularis metacestodes. International journal for parasitology, 30(2), pp. 207-214. Elsevier
Ingold, K; Bigler, P; Thormann, W; Cavaliero, T; Gottstein, Bruno; Hemphill, Andrew (1999). Efficacies of albendazole sulfoxide and albendazole sulfone against In vitro-cultivated Echinococcus multilocularis metacestodes. Antimicrobial agents and chemotherapy, 43(5), pp. 1052-1061. American Society for Microbiology
Eperon, S; Brönnimann, K; Hemphill, Andrew; Gottstein, Bruno (1999). Susceptibility of B-cell deficient C57BL/6 (microMT) mice to Neospora caninum infection. Parasite immunology, 21(5), pp. 225-236. Blackwell Scientific Publications
Hemphill, Andrew; Gajendran, N; Sonda, S; Fuchs, N; Gottstein, Bruno; Hentrich, B; Jenkins, M (1998). Identification and characterisation of a dense granule-associated protein in Neospora caninum tachyzoites. International journal for parasitology, 28(3), pp. 429-438. Elsevier
Gottstein, Bruno; Hemphill, Andrew (1997). Immunopathology of echinococcosis. Chemical immunology, 66, pp. 177-208. Karger
Hemphill, Andrew; Stäger, S; Gottstein, Bruno; Müller, Norbert (1996). Electron microscopical investigation of surface alterations on Giardia lamblia trophozoites after exposure to a cytotoxic monoclonal antibody. Parasitology research, 82(3), pp. 206-210. Springer-Verlag 10.1007/s004360050096
Hemphill, Andrew; Gottstein, Bruno (1996). Identification of a major surface protein on Neospora caninum tachyzoites. Parasitology research, 82(6), pp. 497-504. Springer-Verlag 10.1007/s004360050152
Hemphill, Andrew; Gottstein, Bruno (1995). Immunology and morphology studies on the proliferation of in vitro cultivated Echinococcus multilocularis metacestodes. Parasitology research, 81(7), pp. 605-614. Springer-Verlag 10.1007/BF00932028
