Imhof, Dennis

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2024

Boubaker, Ghalia; Bernal, Alice; Vigneswaran, Anitha; Imhof, Dennis; Ferreira de Sousa, Maria Cristina; Hänggeli, Kai Pascal Alexander; Haudenschild, Noé; Furrer, Julien; Păunescu, Emilia; Desiatkina, Oksana; Hemphill, Andrew (2024). In vitro and in vivo activities of a trithiolato-diRuthenium complex conjugated with sulfadoxine against the apicomplexan parasite Toxoplasma gondii. (In Press). International journal for parasitology. Drugs and drug resistance, 25(100544), p. 100544. Elsevier 10.1016/j.ijpddr.2024.100544

Imhof, Dennis; Hänggeli, Kai Pascal Alexander; Ferreira de Sousa, Maria Cristina; Vigneswaran, Anitha; Hofmann, Larissa; Amdouni, Yosra; Boubaker, Ghalia; Müller, Joachim; Hemphill, Andrew (2024). Working towards the development of vaccines and chemotherapeutics against neosporosis—With all of its ups and downs—Looking ahead. Advances in Parasitology, 124, pp. 91-154. Elsevier 10.1016/bs.apar.2024.01.001

2023

Schlange, Carling; Müller, Joachim; Imhof, Dennis; Hänggeli, Kai Pascal Alexander; Boubaker, Ghalia; Ortega-Mora, Luis-Miguel; Wong, Ho Ning; Haynes, Richard K; Van Voorhis, Wesley C; Hemphill, Andrew (2023). Single and combination treatment of Toxoplasma gondii infections with a bumped kinase inhibitor and artemisone in vitro and with artemiside in experimentally infected mice. Experimental parasitology, 255(108655), p. 108655. Elsevier 10.1016/j.exppara.2023.108655

Ramseier, Jessica; Imhof, Dennis; Hänggeli, Kai Pascal Alexander; Anghel, Nicoleta; Boubaker, Ghalia; Beteck, Richard M; Ortega-Mora, Luis-Miguel; Haynes, Richard K; Hemphill, Andrew (2023). In Vitro versus in Mice: Efficacy and Safety of Decoquinate and Quinoline-O-Carbamate Derivatives against Experimental Infection with Neospora caninum Tachyzoites. Pathogens, 12(3) MDPI AG 10.3390/pathogens12030447

Imhof, Dennis; Pownall, William; Hänggeli, Kai Pascal Alexander; Monney, Camille; Rico-San Román, Laura; Ortega-Mora, Luis-Miguel; Forterre, Franck; Oevermann, Anna; Hemphill, Andrew (2023). Immunization with a Multivalent Listeria monocytogenes Vaccine Leads to a Strong Reduction in Vertical Transmission and Cerebral Parasite Burden in Pregnant and Non-Pregnant Mice Infected with Neospora caninum. Vaccines, 11(1), p. 156. MDPI 10.3390/vaccines11010156

2022

Müller, Joachim; Boubaker, Ghalia; Imhof, Dennis; Hänggeli, Kai; Haudenschild, Noé; Uldry, Anne-Christine; Braga-Lagache, Sophie; Heller, Manfred; Ortega-Mora, Luis-Miguel; Hemphill, Andrew (2022). Differential Affinity Chromatography Coupled to Mass Spectrometry: A Suitable Tool to Identify Common Binding Proteins of a Broad-Range Antimicrobial Peptide Derived from Leucinostatin. Biomedicines, 10(11) MDPI 10.3390/biomedicines10112675

Imhof, Dennis; Pownall, William Robert; Schlange, Carling; Monney, Camille; Ortega-Mora, Luis-Miguel; Ojo, Kayode K; Van Voorhis, Wesley C; Oevermann, Anna; Hemphill, Andrew (2022). Vaccine-Linked Chemotherapy Approach: Additive Effects of Combining the Listeria monocytogenes-Based Vaccine Lm3Dx_NcSAG1 With the Bumped Kinase Inhibitor BKI-1748 Against Neospora caninum Infection in Mice. Frontiers in veterinary science, 9, p. 901056. Frontiers Media 10.3389/fvets.2022.901056

Müller, Joachim; Anghel, Nicoleta; Imhof, Dennis; Hänggeli, Kai; Uldry, Anne-Christine; Braga-Lagache, Sophie; Heller, Manfred; Ojo, Kayode K; Ortega-Mora, Luis-Miguel; Van Voorhis, Wesley C; Hemphill, Andrew (2022). Common Molecular Targets of a Quinolone Based Bumped Kinase Inhibitor in Neospora caninum and Danio rerio. International journal of molecular sciences, 23(4) MDPI 10.3390/ijms23042381

2021

Anghel, Nicoleta; Imhof, Dennis; Winzer, Pablo; Balmer, Vreni; Ramseier, Jessica; Haenggeli, Kai; Choi, Ryan; Hulverson, Matthew A; Whitman, Grant R; Arnold, Samuel L M; Ojo, Kayode K; Van Voorhis, Wesley C; Doggett, J Stone; Ortega-Mora, Luis M; Hemphill, Andrew (2021). Endochin-like quinolones (ELQs) and bumped kinase inhibitors (BKIs): Synergistic and additive effects of combined treatments against Neospora caninum infection in vitro and in vivo. International journal for parasitology. Drugs and drug resistance, 17, pp. 92-106. Elsevier 10.1016/j.ijpddr.2021.08.007

Imhof, Dennis; Pownall, William Robert; Monney, Camille; Oevermann, Anna; Hemphill, Andrew (2021). A Listeria monocytogenes-Based Vaccine Formulation Reduces Vertical Transmission and Leads to Enhanced Pup Survival in a Pregnant Neosporosis Mouse Model. Vaccines, 9(12) MDPI 10.3390/vaccines9121400

Anghel, Nicoleta; Müller, Joachim; Serricchio, Mauro; Jelk, Jennifer; Bütikofer, Peter; Boubaker, Ghalia; Imhof, Dennis; Ramseier, Jessica; Desiatkina, Oksana; Paunescu, Emilia; Braga, Sophie Marie-Pierre; Heller, Manfred; Furrer, Julien; Hemphill, Andrew (2021). Cellular and Molecular Targets of Nucleotide-Tagged Trithiolato-Bridged Arene Ruthenium Complexes in the Protozoan Parasites Toxoplasma gondii and Trypanosoma brucei. International journal of molecular sciences, 22(19) Molecular Diversity Preservation International MDPI 10.3390/ijms221910787

Imhof, Dennis; Anghel, Nicoleta; Winzer, Pablo; Balmer, Vreni; Ramseier, Jessica; Hänggeli, Kai; Choi, Ryan; Hulverson, Matthew A; Whitman, Grant R; Arnold, Samuel L M; Ojo, Kayode K; Van Voorhis, Wesley C; Doggett, J Stone; Ortega-Mora, Luis M; Hemphill, Andrew (2021). In vitro activity, safety and in vivo efficacy of the novel bumped kinase inhibitor BKI-1748 in non-pregnant and pregnant mice experimentally infected with Neospora caninum tachyzoites and Toxoplasma gondii oocysts. International journal for parasitology. Drugs and drug resistance, 16, pp. 90-101. Elsevier 10.1016/j.ijpddr.2021.05.001

Van Voorhis, Wesley C; Hulverson, Matthew A; Choi, Ryan; Huang, Wenlin; Arnold, Samuel L M; Schaefer, Deborah A; Betzer, Dana P; Vidadala, Rama S R; Lee, Sangun; Whitman, Grant R; Barrett, Lynn K; Maly, Dustin J; Riggs, Michael W; Fan, Erkang; Kennedy, Thomas J; Tzipori, Saul; Doggett, J Stone; Winzer, Pablo; Anghel, Nicoleta; Imhof, Dennis; ... (2021). One health therapeutics: Target-Based drug development for cryptosporidiosis and other apicomplexa diseases. Veterinary parasitology, 289, p. 109336. Elsevier 10.1016/j.vetpar.2020.109336

Pownall, William Robert; Imhof, Dennis; Fernandez Trigo, Nerea; Ganal-Vonarburg, Stephanie C.; Plattet, Philippe; Monney, Camille; Forterre, Franck; Hemphill, Andrew; Oevermann, Anna (2021). Safety of a Novel Listeria monocytogenes-Based Vaccine Vector Expressing NcSAG1 (Neospora caninum Surface Antigen 1). Frontiers in cellular and infection microbiology, 11(675219), p. 675219. Frontiers 10.3389/fcimb.2021.675219

Ramseier, Jessica; Imhof, Dennis; Anghel, Nicoleta; Hänggeli, Kai; Beteck, Richard M.; Balmer, Vreni; Ortega-Mora, Luis-Miguel; Sanchez-Sanchez, Roberto; Ferre, Ignacio; Haynes, Richard K.; Hemphill, Andrew (2021). Assessment of the Activity of Decoquinate and Its Quinoline-O-Carbamate Derivatives against Toxoplasma gondii In Vitro and in Pregnant Mice Infected with T. gondii Oocysts. Molecules, 26(21), p. 6393. Molecular Diversity Preservation International MDPI 10.3390/molecules26216393

2020

Anghel, Nicoleta; Winzer, Pablo A.; Imhof, Dennis; Müller, Joachim; Langa, Javier; Rieder, Jessica; Barrett, Lynn K.; Vidadala, Rama Subba Rao; Huang, Wenlin; Choi, Ryan; Hulverson, Mathew A.; Whitman, Grant R.; Arnold, Samuel L.; Van Voorhis, Wesley C.; Ojo, Kayode K.; Maly, Dustin J.; Fan, Erkang; Hemphill, Andrew (2020). Comparative assessment of the effects of bumped kinase inhibitorson early zebrafish embryo development and pregnancy in mice. International journal of antimicrobial agents, 56(3), p. 106099. Elsevier 10.1016/j.ijantimicag.2020.106099

Winzer, Pablo; Müller, Joachim; Imhof, Dennis; Ritler, Dominic; Uldry, Anne-Christine; Braga-Lagache, Sophie; Heller, Manfred; Ojo, Kayode K; Van Voorhis, Wesley C; Ortega-Mora, Luis-Miguel; Hemphill, Andrew (2020). Neospora caninum: Differential Proteome of Multinucleated Complexes Induced by the Bumped Kinase Inhibitor BKI-1294. Microorganisms, 8(6) MDPI 10.3390/microorganisms8060801

Winzer, Pablo Arnold; Anghel, Nicoleta; Imhof, Dennis; Balmer, Vreni; Ortega-Mora, Luis-Miguel; Ojo, Kayode K; Van Voorhis, Wesley C; Müller, Joachim; Hemphill, Andrew (2020). Neospora caninum: Structure and Fate of Multinucleated Complexes Induced by the Bumped Kinase Inhibitor BKI-1294. Pathogens, 9(5) MDPI AG 10.3390/pathogens9050382

Winzer, Pablo; Imhof, Dennis; Anghel, Nicoleta; Ritler, Dominic; Müller, Joachim; Boubaker, Ghalia; Aguado-Martinez, Adriana; Ortega-Mora, Luis-Miguel; Ojo, Kayode K; VanVoorhis, Wesley C; Hemphill, Andrew (2020). The Impact of BKI-1294 Therapy in Mice Infected With the Apicomplexan Parasite Neospora caninum and Re-infected During Pregnancy. Frontiers in veterinary science, 7, p. 587570. Frontiers Media 10.3389/fvets.2020.587570

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