Kucera, Jan

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Maguy, Ange; Kucera, Jan; Wepfer, Jonas P.; Forest, Virginie; Charpentier, Flavien; Li, Jin (2020). KCNQ1 Antibodies for Immunotherapy of Long QT Syndrome Type 2. Journal of the American College of Cardiology, 75(17), pp. 2140-2152. Elsevier 10.1016/j.jacc.2020.02.067

De Simone, Stefano Andrea; Moyle, Sarah; Buccarello, Andrea; Dellenbach, Christian; Kucera, Jan; Rohr, Stephan (2020). The Role of Membrane Capacitance in Cardiac Impulse Conduction: An Optogenetic Study With Non-excitable Cells Coupled to Cardiomyocytes. Frontiers in physiology, 11(194), p. 194. Frontiers Research Foundation 10.3389/fphys.2020.00194

Alijevic, Omar; Bignucolo, Olivier; Hichri, Echrak; Peng, Zhong; Kucera, Jan P.; Kellenberger, Stephan (2020). Slowing of the Time Course of Acidification Decreases the Acid-Sensing Ion Channel 1a Current Amplitude and Modulates Action Potential Firing in Neurons. Frontiers in cellular neuroscience, 14(41), p. 41. Frontiers Research Foundation 10.3389/fncel.2020.00041

Hichri, Echrak; Selimi, Zoja; Kucera, Jan P. (2020). Modeling the Interactions Between Sodium Channels Provides Insight Into the Negative Dominance of Certain Channel Mutations. Frontiers in physiology, 11, p. 589386. Frontiers Research Foundation 10.3389/fphys.2020.589386


Vermij, Sarah Helena; Abriel, Hugues; Kucera, Jan (2019). Modeling Depolarization Delay, Sodium Currents, and Electrical Potentials in Cardiac Transverse Tubules. Frontiers in physiology, 10(1487) Frontiers Research Foundation 10.3389/fphys.2019.01487


Buccarello, Andrea; Azzarito, Michela; Michoud, Frédéric; Lacour, Stéphanie P.; Kucera, Jan (2018). Uniaxial strain of cultured mouse and rat cardiomyocyte strands slows conduction more when its axis is parallel to impulse propagation than when it is perpendicular. Acta physiologica, 223(1), e13026. Blackwell Publishing 10.1111/apha.13026

Hichri, Echrak; Abriel, Hugues; Kucera, Jan (2018). Distribution of cardiac sodium channels in clusters potentiates ephaptic interactions in the intercalated disc. Journal of physiology, 596(4), pp. 563-589. Wiley-Blackwell 10.1113/JP275351


Kucera, Jan; Rohr, Stephan; Kléber, André-Georges (2017). Microstructure, Cell-to-Cell Coupling, and Ion Currents as Determinants of Electrical Propagation and Arrhythmogenesis. Circulation - arrhythmia and electrophysiology, 10(9), e004665. Lippincott Williams & Wilkins 10.1161/CIRCEP.117.004665


Jousset, Florian; Maguy, Ange; Rohr, Stephan; Kucera, Jan (2016). Myofibroblasts Electrotonically Coupled to Cardiomyocytes Alter Conduction: Insights at the Cellular Level from a Detailed In silico Tissue Structure Model. Frontiers in physiology, 7(496) Frontiers Research Foundation 10.3389/fphys.2016.00496


Kucera, Jan; Prudat, Yann; Marcu, Irene Cristina; Azzarito, Michela; Ullrich, Nina (2015). Slow conduction in mixed cultured strands of primary ventricular cells and stem cell-derived cardiomyocytes. Frontiers in cell and developmental biology, 3, p. 58. Frontiers 10.3389/fcell.2015.00058


Kucera, Jan (2014). What makes the heart rhythm so intricate? Heart rhythm, 11(7), pp. 1220-1221. Elsevier 10.1016/j.hrthm.2014.04.013

Prudat, Yann; Kucera, Jan (2014). Nonlinear behaviour of conduction and block in cardiac tissue with heterogeneous expression of connexin 43. Journal of molecular and cellular cardiology, 76, pp. 46-54. Elsevier 10.1016/j.yjmcc.2014.07.019

Swan, H.; Amarouch, Mohamed Yassine; Leinonen, J.; Marjamaa, A.; Kucera, Jan; Laitinen-Forsblom, P. J.; Lahtinen, A. M.; Palotie, A.; Kontula, K.; Toivonen, L.; Abriel, Hugues; Widen, E. (2014). Gain-of-Function Mutation of the SCN5A Gene Causes Exercise-Induced Polymorphic Ventricular Arrhythmias. Circulation - cardiovascular genetics, 7(6), pp. 771-781. Lippincott Williams & Wilkins 10.1161/CIRCGENETICS.114.000703


Abriel, Hugues; De Lange, Enno Karel; Kucera, Jan; Loussouarn, Gildas; Tarek, Mounir (2013). Computational tools to investigate genetic cardiac channelopathies. Frontiers in physiology, 4, p. 390. Frontiers Research Foundation 10.3389/fphys.2013.00390

Sottas, Valentin; Rougier, Jean-Sébastien; Jousset, Florian; Kucera, Jan P.; Shestak, Anna; Makarov, Leonid M.; Zaklyazminskaya, Elena V.; Abriel, Hugues (2013). Characterization of 2 genetic variants of Na(v) 1.5-arginine 689 found in patients with cardiac arrhythmias. Journal of cardiovascular electrophysiology, 24(9), pp. 1037-1046. Wiley-Blackwell 10.1111/jce.12173


Borgstrom, N P; Prudat, Y; Olcese, R; De Lange, E; Kucera, J P (2012). Early detection of action potential duration alternans using an autoregressive model. Biophysical journal, 102(3 S1) L192-Pos. Bethesda, Md.: Biophysical Society


J.P. Kucera, ; M. Lemay, (2011). Evaluation of the propensity to alternans using spectral analysis of stochastic beat-to-beat APD variations. In: Gordon Research Conference on Cardiac Arrhythmia Mechanisms, Galveston, Texas, USA..

J.P. Kucera, ; M. Lemay, ; E. de Lange, (2011). Probing cardiac dynamics with random pacing and frequency domain approaches. Oral communication at the Forum of the Theo Rossi di Montelera Foundation on Computer Simulation and Experimental Assessment of Cardiac Electrical Function (chair: Prof. Lukas Kappenberger). In: Lugano, Switzerland.


de Lange, E; Kucera, J P (2010). Alternans resonance and propagation block during supernormal conduction in cardiac tissue with decreased [K+]o. Biophysical journal, 98(7), pp. 1129-1138. Bethesda, Md.: Biophysical Society 10.1016/j.bpj.2009.12.4280

Kucera, J.P.; de Lange, E. (2010). Effects of Stochastic Channel Gating and Stochastic Channel Distribution on the Cardiac Action Potential. Biophysical journal, 98(3), 334a. Bethesda, Md.: Biophysical Society

Lemay, Mathieu; Beauchamp, Philippe; Kléber, André-Georges; Kucera, Jan (2010). Stochastic beat-to-beat variations of conduction in connexin 43 deficient murine ventricular tissue during steady state pacing. In: 16th Cardiovascular Biology and Clinical Implications Meeting. Muntelier, Switzerland. 7-8 October 2010.


Wustmann, Kerstin; Kucera, Jan P; Scheffers, Ingrid; Mohaupt, Markus; Kroon, Abraham A; de Leeuw, Peter W; Schmidli, Jürg; Allemann, Yves; Delacrétaz, Etienne (2009). Effects of chronic baroreceptor stimulation on the autonomic cardiovascular regulation in patients with drug-resistant arterial hypertension. Hypertension, 54(3), pp. 530-6. Philadelphia, Pa.: Lippincott Williams & Wilkins 10.1161/HYPERTENSIONAHA.109.134023


Wustmann, K; Kucera, J P; Zanchi, A; Burow, A; Stuber, T; Chappuis, B; Diem, P; Delacrétaz, E (2008). Activation of electrical triggers of atrial fibrillation in hyperthyroidism. Journal of clinical endocrinology and metabolism, 93(6), pp. 2104-8. Chevy Chase, Md.: Endocrine Society 10.1210/jc.2008-0092

Munteanu, A; Kondratyev, A A; Kucera, J P (2008). Analysis of damped oscillations during reentry: A new approach to evaluate cardiac restitution. Biophysical journal, 94(3), pp. 1094-1109. Bethesda, Md.: Biophysical Society 10.1529/biophysj.107.113811

Petitprez, S; Jespersen, T; Pruvot, E; Keller, D I; Corbaz, C; Schläpfer, J; Abriel, H; Kucera, J P (2008). Analysis of a novel SCN5A mutation (C1850S): conduction vs. repolarization disorder hypotheses in the Brugada syndrome. Cardiovascular research, 78(3), pp. 494-504. Oxford: Oxford University Press 10.1093/cvr/cvn023

de Lange, E; Kucera, JP (2008). Supernormal conduction of premature impulses potentiates alternans in cardiac tissue. Biophysical journal, 90(4), 601a-602a 30004-Pos. Bethesda, Md.: Biophysical Society

de Lange, E; Kucera, JP (2008). Evaluation of the stability of cardiac conduction using stochastic pacing and spectral analysis. In: 14th Cardiovascular Biology and Clinical Implications Meeting, Murten Switzerland.

Kucera, J; de Lange, E (2008). Measuring the Slopes of Restitution Curves in Cardiac Tissue with a Random Pacing Protocol. Biophysical journal, 90(4), 601a 3002-Pos. Bethesda, Md.: Biophysical Society

Wustmann, K; Kucera, J P; Scheffers, I; Allemann, Y; Schmidli, J; Delacrétaz, E (2008). Effects of chronic electrical baroreceptor stimulation on the sympathovagal balance in humans with drug-resistant arterial hypertension. In: Annual Congress of the Swiss Society of Cardiology, Bern, Switzerland, 2008.

de Lange, E; Kucera, J P (2008). Assessing the local stability of action potential propagation in cardiac tissue. In: Proceedings of the 2008 InternationalSymposium on Nonlinear Theory and its Applications, Nolta, Budapest.


Ponard, Julien G C; Kondratyev, Aleksandar A; Kucera, Jan P (2007). Mechanisms of intrinsic beating variability in cardiac cell cultures and model pacemaker networks. Biophysical journal, 92(10), pp. 3734-52. Bethesda, Md.: Biophysical Society 10.1529/biophysj.106.091892


Sperlingová, I; Dabrowská, L; Stránský, V; Kucera, J; Tichý, M (2006). Human urine certified reference material CZ 6010: creatinine and toluene metabolites (hippuric acid and o-cresol) and a benzene metabolite (phenol). Analytical and bioanalytical chemistry, 387(7), pp. 2419-2424. Heidelberg: Springer 10.1007/s00216-006-0708-7

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