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Läppchen, Tilman; Bilinska, Adrianna; Pilatis, Eirinaios; Menéndez, Elena; Imlimthan, Surachet; Moon, Euy Sung; Afshar-Oromieh, Ali; Rösch, Frank; Rominger, Axel; Gourni, Eleni (2024). Tailoring Fibroblast-Activation Protein Targeting for Theranostics: A Comparative Preclinical Evaluation of the 68Ga- and 177Lu-Labeled Monomeric and Dimeric Fibroblast-Activation Protein Inhibitors DOTA.SA.FAPi and DOTAGA.(SA.FAPi)2. Molecules, 29(13) MDPI 10.3390/molecules29133093
Escudero-Castellanos, Alondra; Kurth, Jens; Imlimthan, Surachet; Menéndez, Elena; Pilatis, Eirinaios; Moon, Euy Sung; Läppchen, Tilman; Rathke, Hendrik; Schwarzenböck, Sarah M; Krause, Bernd J; Rösch, Frank; Rominger, Axel; Gourni, Eleni (2023). Translational assessment of a DATA-functionalized FAP inhibitor with facile 68Ga-labeling at room temperature. European journal of nuclear medicine and molecular imaging, 50(11), pp. 3202-3213. Springer 10.1007/s00259-023-06285-2
D'Onofrio, Alice; Engelbrecht, Swantje; Läppchen, Tilman; Rominger, Axel; Gourni, Eleni (2023). GRPR-targeting radiotheranostics for breast cancer management. Frontiers in medicine, 10, p. 1250799. Frontiers 10.3389/fmed.2023.1250799
Imlimthan, Surachet; Menéndez, Elena; Escudero-Castellanos, Alondra; Moon, Euy Sung; Läppchen, Tilman; Rathke, Hendrik; Afshar-Oromieh, Ali; Roesch, Frank; Rominger, Axel; Gourni, Eleni (2022). Investigation of 68Ga/177Lu-labeled FAP-based inhibitor for diagnostic and therapeutic applications. Nuclear medicine and biology, 108-109, S56-S57. Elsevier 10.1016/S0969-8051(22)00147-0
Escudero-Castellanos, Alondra; Imlimthan, Surachet; Menéndez, Elena; Moon, Euy Sung; Läppchen, Tilman; Rathke, Hendrik; Afshar Oromieh, Ali; Roesch, Frank; Rominger, Axel; Gourni, Eleni (2022). Tumor stroma diagnostic imaging by a 68Ga-coupled small-molecule fibroblast activation protein (FAP) inhibitor: first pre-clinical data. Nuclear medicine and biology, 108-109, S186-S187. Elsevier 10.1016/S0969-8051(22)00388-2
Imlimthan, S.; Menéndez, E.; Escudero-Castellanos, A.; Moon, E.S.; Läppchen, T.; Rathke, H.; Afshar Oromieh, A.; Röesch, F.; Rominger, A.; Gourni, E. (2022). Preclinical evaluation of a 68Ga-labeled squaric acid-based FAP inhibitor for PET applications. Nuklearmedizin, 61(02), pp. 165-166. Thieme 10.1055/s-0042-1746024
Alberts, Ian; Niklas-Hünermund, Jan; Sachpekidis, Christos; Zacho, Helle Damgaard; Mingels, Clemens; Dijkstra, Lotte; Bohn, Karl Peter; Läppchen, Tilman; Gourni, Eleni; Rominger, Axel; Afshar-Oromieh, Ali (2021). Combination of Forced Diuresis with Additional Late Imaging in 68Ga-PSMA-11 PET/CT: Effects on Lesion Visibility and Radiotracer Uptake. Journal of nuclear medicine, 62(9), pp. 1252-1257. Society of Nuclear Medicine 10.2967/jnumed.120.257741
Meier, Lorenz P; Läppchen, Tilman; Rominger, Axel; Hentschel, Michael; Prenosil, George A (2021). 3D Printing of Germanium-68 PET Phantoms. In: 2021 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC) (pp. 1-4). IEEE 10.1109/NSS/MIC44867.2021.9875768
Läppchen, Tilman; Meier, Lorenz P.; Fürstner, Markus; Prenosil, George; Krause, Thomas; Rominger, Axel; Klaeser, Bernd; Hentschel, Michael (2020). 3D printing of radioactive phantoms for nuclear medicine imaging. EJNMMI Physics, 7(1), p. 22. Springer 10.1186/s40658-020-00292-0
Läppchen, Tilman; Kiefer, Yvonne; Holland, Jason P.; Bartholomä, Mark D. (2018). In vitro and in vivo evaluation of the bifunctional chelator NODIA-Me in combination with a prostate-specific membrane antigen targeting vector. Nuclear medicine and biology, 60, pp. 45-54. Elsevier 10.1016/j.nucmedbio.2018.03.002
Läppchen, Tilman; Holland, Jason P.; Kiefer, Yvonne; Bartholomä, Mark D. (2018). Preparation and preclinical evaluation of a 68Ga-labelled c(RGDfK) conjugate comprising the bifunctional chelator NODIA-Me. EJNMMI Radiopharmacy and Chemistry, 3(1), p. 6. Springer 10.1186/s41181-018-0043-2
Weinmann, Christian; Holland, Jason P.; Läppchen, Tilman; Scherer, Harald; Maus, Stephan; Stemler, Tobias; Bohnenberger, Hendrik; Ezziddin, Samer; Kurz, Philipp; Bartholomä, Mark D. (2018). Optimized synthesis and indium complex formation with the bifunctional chelator NODIA-Me. Organic & biomolecular chemistry, 16(40), pp. 7503-7512. Royal Society of Chemistry 10.1039/c8ob01981a
Läppchen, Tilman; Rossin, Raffaella; van Mourik, Tiemen R; Gruntz, Guillaume; Hoeben, Freek J M; Versteegen, Ron M; Janssen, Henk M; Lub, Johan; Robillard, Marc S (2017). DOTA-tetrazine probes with modified linkers for tumor pretargeting. Nuclear medicine and biology, 55, pp. 19-26. Elsevier 10.1016/j.nucmedbio.2017.09.001
Schmidtke, Alexander; Läppchen, Tilman; Weinmann, Christian; Bier-Schorr, Lorenz; Keller, Manfred; Kiefer, Yvonne; Holland, Jason P; Bartholomä, Mark D (2017). Gallium Complexation, Stability, and Bioconjugation of 1,4,7-Triazacyclononane Derived Chelators with Azaheterocyclic Arms. Inorganic chemistry, 56(15), pp. 9097-9110. American Chemical Society 10.1021/acs.inorgchem.7b01129
van de Steeg, Evita; Läppchen, Tilman; Aguilera, Begoña; Jansen, Harm T; Muilwijk, Daan; Vermue, Rick; van der Hoorn, José W; Donato, Katia; Rossin, Raffaella; de Visser, Peter C; Vlaming, Maria L H (2017). Feasibility of SPECT-CT Imaging to Study the Pharmacokinetics of Antisense Oligonucleotides in a Mouse Model of Duchenne Muscular Dystrophy. Nucleic acid therapeutics, 27(4), pp. 221-231. Mary Ann Liebert 10.1089/nat.2016.0649
Läppchen, Tilman; Tönnesmann, Roswitha; Eersels, Jos; Meyer, Philipp T; Maecke, Helmut R; Rylova, Svetlana N (2017). Radioiodinated Exendin-4 Is Superior to the Radiometal-Labelled Glucagon-Like Peptide-1 Receptor Probes Overcoming Their High Kidney Uptake. PLoS ONE, 12(1), e0170435. Public Library of Science 10.1371/journal.pone.0170435