Müller, Joachim

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Silva Pinto Basto, Afonso; Anghel, Nicoleta; Rubbiani, Riccardo; Müller, Joachim; Stibal, David; Giannini, Federico; Süss-Fink, Georg; Balmer, Vreni; Gasser, Gilles; Furrer, Julien; Hemphill, Andrew (2019). Targeting of the mitochondrion by dinuclear thiolato-bridged arene ruthenium complexes in cancer cells and in the apicomplexan parasite Neospora caninum. Metallomics, 11(2), pp. 462-474. Royal Society of Chemistry 10.1039/C8MT00307F


De Amorim Cardoso, Rita Isabel; Wang, Junhua; Müller, Joachim; Rupp, Sebastian Dominic Alexander; Leitão, Alexandre; Hemphill, Andrew (2018). Modulation of cis- and trans- Golgi and the Rab9A-GTPase during infection by Besnoitia besnoiti, Toxoplasma gondii and Neospora caninum. Experimental parasitology, 187, pp. 75-85. Elsevier 10.1016/j.exppara.2018.02.008

Rufener, Reto; Ritler, Dominic; Zielinski, Jana; Dick, Luca; da Silva, Emerson Teixeira; da Silva Araujo, Adriele; Joekel, Deborah Elisabeth; Czock, David; Göpfert, Christine; Moraes, Adriana Marques; de Souza, Marcus Vinicius Nora; Müller, Joachim; Mevissen, Meike; Hemphill, Andrew; Lundström-Stadelmann, Britta (2018). Activity of mefloquine and mefloquine derivatives against Echinococcus multilocularis. International journal for parasitology. Drugs and drug resistance, 8(2), pp. 331-340. Elsevier 10.1016/j.ijpddr.2018.06.004

Müller, Joachim; Hemphill, Andrew; Müller, Norbert (2018). Physiological aspects of nitro drug resistance in Giardia lamblia. International journal for parasitology. Drugs and drug resistance, 8(2), pp. 271-277. Elsevier 10.1016/j.ijpddr.2018.04.008


Harmse, Rozanne; Wong, Ho Ning; Smit, Frans J; Müller, Joachim; Hemphill, Andrew; N'Da, David D; Haynes, Richard K (2017). Activities of 11-Azaartemisinin and N-Sulfonyl Derivatives against Neospora caninum and Comparative Cytotoxicities. ChemMedChem, 12(24), pp. 2094-2098. Wiley-VCH 10.1002/cmdc.201700600

Hulverson, Matthew A; Choi, Ryan; Arnold, Samuel L M; Schaefer, Deborah A; Hemphill, Andrew; McCloskey, Molly C; Betzer, Dana P; Müller, Joachim; Vidadala, Rama S R; Whitman, Grant R; Rivas, Kasey L; Barrett, Lynn K; Hackman, Robert C; Love, Melissa S; McNamara, Case W; Shaughnessy, Thomas K; Kondratiuk, Alison; Kurnick, Matthew; Banfor, Patricia N; Lynch, James J; ... (2017). Advances in bumped kinase inhibitors for human and animal therapy for cryptosporidiosis. International journal for parasitology, 47(12), pp. 753-763. Elsevier 10.1016/j.ijpara.2017.08.006

Müller, Joachim; Aguado Martinez, Adriana; Laleu, Benoît; Balmer, Vreni; Ritler, Dominic; Hemphill, Andrew (2017). In vitro screening of the open source Pathogen Box identifies novel compounds with profound activities against Neospora caninum. International journal for parasitology, 47(12), pp. 801-809. Elsevier 10.1016/j.ijpara.2017.06.002

Müller, Joachim; Aguado Martinez, Adriana; Ortega-Mora, Luis-Miguel; Moreno-Gonzalo, Javier; Ferre, Ignacio; Hulverson, Matthew A; Choi, Ryan; McCloskey, Molly C; Barrett, Lynn K; Maly, Dustin J; Ojo, Kayode K; Van Voorhis, Wes; Hemphill, Andrew (2017). Development of a murine vertical transmission model for Toxoplasma gondii oocyst infection and studies on the efficacy of bumped kinase inhibitor (BKI)-1294 and the naphthoquinone buparvaquone against congenital toxoplasmosis. Journal of antimicrobial chemotherapy, 72(8), pp. 2334-2341. Oxford University Press 10.1093/jac/dkx134

Silva Pinto Basto, Afonso; Müller, Joachim; Rubbiani, Riccardo; Stibal, David; Giannini, Federico; Süss-Fink, Georg; Balmer, Vreni; Hemphill, Andrew; Gasser, Gilles; Furrer, Julien (2017). Characterization of the Activities of Dinuclear Thiolato-Bridged Arene Ruthenium Complexes against Toxoplasma gondii. Antimicrobial agents and chemotherapy, 61(9), e01031-17. American Society for Microbiology 10.1128/AAC.01031-17

Müller, Joachim; Aguado Martinez, Adriana; Balmer, Vreni; Maly, Dustin J; Fan, Erkang; Ortega-Mora, Luis-Miguel; Ojo, Kayode K; Van Voorhis, Wesley C; Hemphill, Andrew (2017). Two novel calcium-dependent kinase 1-inhibitors interfere with vertical transmission in mice infected with Neospora caninum tachyzoites. Antimicrobial agents and chemotherapy, 61(4) American Society for Microbiology 10.1128/AAC.02324-16

Serra, Fabienne Heirangi; Müller, Joachim; Gray, John; Lüthi, Ramona; Dudas, Sandor; Czub, Stefanie; Seuberlich, Torsten (2017). PrP-C1 fragment in cattle brains reveals features of the transmissible spongiform encephalopathy associated PrP(sc). Brain research, 1659, pp. 19-28. Elsevier 10.1016/j.brainres.2017.01.015


Leitsch, David; Müller, Joachim; Müller, Norbert (2016). Evaluation of Giardia lamblia thioredoxin reductase as drug activating enzyme and as drug target. International journal for parasitology. Drugs and drug resistance, 6(3), pp. 148-153. Elsevier 10.1016/j.ijpddr.2016.07.003

Müller, Joachim; Hemphill, Andrew (2016). Drug target identification in protozoan parasites. Expert opinion on drug discovery, 11(8), pp. 815-824. Taylor & Francis 10.1080/17460441.2016.1195945

Van Voorhis, Wesley C; Adams, John H; Adelfio, Roberto; Ahyong, Vida; Akabas, Myles H; Alano, Pietro; Alday, Aintzane; Alemán Resto, Yesmalie; Alsibaee, Aishah; Alzualde, Ainhoa; Andrews, Katherine T; Avery, Simon V; Avery, Vicky M; Ayong, Lawrence; Baker, Mark; Baker, Stephen; Ben Mamoun, Choukri; Bhatia, Sangeeta; Bickle, Quentin; Bounaadja, Lotfi; ... (2016). Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond. PLoS pathogens, 12(7), e1005763. Public Library of Science 10.1371/journal.ppat.1005763

Hostettler, Isabel; Müller, Joachim; Hemphill, Andrew (2016). In Vitro Screening of the Open-Source Medicines for Malaria Venture Malaria Box Reveals Novel Compounds with Profound Activities against Theileria annulata Schizonts. Antimicrobial agents and chemotherapy, 60(6), pp. 3301-3308. American Society for Microbiology 10.1128/AAC.02801-15

Aguado Martinez, Adriana; Silva Pinto Basto, Afonso; Müller, Joachim; Balmer, Vreni; Manser, Vera; Leitão, Alexandre; Hemphill, Andrew (2016). N-terminal fusion of a toll-like receptor 2-ligand to a Neospora caninum chimeric antigen efficiently modifies the properties of the specific immune response. Parasitology, 143(5), pp. 606-616. Cambridge University Press 10.1017/S0031182016000056

Hemphill, Andrew; Aguado Martinez, Adriana; Müller, Joachim (2016). Approaches for the vaccination and treatment of Neospora caninum infections in mice and ruminant models. Parasitology, 143(3), pp. 245-259. Cambridge University Press 10.1017/S0031182015001596

Müller, Joachim; Aguado Martinez, Adriana; Manser, Vera; Wong, Ho Ning; Haynes, Richard K; Hemphill, Andrew (2016). Repurposing of antiparasitic drugs: the hydroxy-naphthoquinone buparvaquone inhibits vertical transmission in the pregnant neosporosis mouse model. Veterinary research, 47, p. 32. BioMed Central 10.1186/s13567-016-0317-1

Müller, Norbert; Müller, Joachim (2016). Giardia. In: Walochnik, Julia; Duchêne, Michael (eds.) Molecular Parasitology (pp. 93-114). Wien: Springer Verlag 10.1007/978-3-7091-1416-2_4


Küster, Tatiana; Lundström-Stadelmann, Britta; Rufener, Reto; Risch, Corina; Müller, Joachim; Hemphill, Andrew (2015). Oral treatments of Echinococcus multilocularis-infected mice with the antimalarial drug mefloquine that potentially interacts with parasite ferritin and cystatin. International journal of antimicrobial agents, 46(5), pp. 546-551. Elsevier 10.1016/j.ijantimicag.2015.07.016

Winzer, Pablo Arnold; Müller, Joachim; Aguado Martinez, Adriana; Rahman, Mahbubur; Balmer, Vreni; Manser, Vera; Ortega-Mora, Luis Miguel; Ojo, Kayode K; Fan, Erkang; Maly, Dustin J; Van Voorhis, Wesley C; Hemphill, Andrew (2015). In Vitro and In Vivo Effects of the Bumped Kinase Inhibitor 1294 in the Related Cyst-Forming Apicomplexans Toxoplasma gondii and Neospora caninum. Antimicrobial agents and chemotherapy, 59(10), pp. 6361-6374. American Society for Microbiology 10.1128/AAC.01236-15

Müller, Joachim; Rout, Samuel; Leitsch, David; Vaithilingam, Jathana; Hehl, Adrian; Müller, Norbert (2015). Comparative characterisation of two nitroreductases from Giardia lamblia as potential activators of nitro compounds. International journal for parasitology. Drugs and drug resistance, 5(2), pp. 37-43. Elsevier 10.1016/j.ijpddr.2015.03.001

Arranz Solis, David; Aguado Martinez, Adriana; Müller, Joachim; Regidor-Cerrillo, Javier; Ortega-Mora, Luis Miguel; Hemphill, Andrew (2015). Dose-dependent effects of experimental infection with the virulent Neospora caninum Nc-Spain7 isolate in a pregnant mouse model. Veterinary parasitology, 211(3-4), pp. 133-140. Elsevier 10.1016/j.vetpar.2015.05.021

Müller, Joachim; Balmer, Vreni; Winzer, Pablo Arnold; Rahman, Mahbubur; Manser, Vera; Haynes, Richard K; Hemphill, Andrew (2015). In vitro effects of new artemisinin derivatives in Neospora caninum-infected human fibroblasts. International journal of antimicrobial agents, 46(1), pp. 88-93. Elsevier 10.1016/j.ijantimicag.2015.02.020

Müller, Joachim; Aguado Martinez, Adriana; Manser, Vera; Balmer, Vreni; Winzer, Pablo Arnold; Ritler, Dominic; Hostettler, Isabel; Arranz Solis, David; Ortega-Mora, Luis; Hemphill, Andrew (2015). Buparvaquone is active against Neospora caninum in vitro and in experimentally infected mice. International journal for parasitology. Drugs and drug resistance, 5(1), pp. 16-25. Elsevier 10.1016/j.ijpddr.2015.02.001


Hostettler, Isabel; Müller, Joachim; Stephens, Chad E; Haynes, Richard; Hemphill, Andrew (2014). A quantitative reverse-transcriptase PCR assay for the assessment of drug activities against intracellular Theileria annulata schizonts. International journal for parasitology. Drugs and drug resistance, 4(3), pp. 201-209. Elsevier 10.1016/j.ijpddr.2014.09.003

Lundström-Stadelmann, Britta; Aeschbacher, Denise; Huber, Cristina; Spiliotis, Markus; Müller, Joachim; Hemphill, Andrew (2014). Profound activity of the anti-cancer drug bortezomib against Echinococcus multilocularis metacestodes identifies the proteasome as a novel drug target for cestodes. PLoS neglected tropical diseases, 8(12), e3352. Public Library of Science 10.1371/journal.pntd.0003352

Hemphill, Andrew; Lundström-Stadelmann, Britta; Rufener, Reto; Spiliotis, Markus; Boubaker, Ghalia; Müller, Joachim; Müller, Norbert; Gorgas, Daniela; Gottstein, Bruno (2014). Treatment of echinococcosis: albendazole and mebendazole - what else? Parasite, 21, p. 70. Princeps Editions 10.1051/parasite/2014073

Müller, Joachim; Vaithilingam, Jathana; Rosner, Judah Lee; Müller, Norbert (2014). Escherichia coli are susceptible to thiazolides if the tolc efflux system is inhibited. Journal of Developing Drugs, 3(2), p. 1000124. OMICS Group 10.4172/2329-6631.1000124

Ojo, Kayode K; Reid, Molly C; Kallur Siddaramaiah, Latha; Müller, Joachim; Winzer, Pablo Arnold; Zhang, Zhongsheng; Keyloun, Katelyn R; Vidadala, Rama Subba Rao; Merritt, Ethan A; Hol, Wim G J; Maly, Dustin J; Fan, Erkang; Van Voorhis, Wesley C; Hemphill, Andrew (2014). Neospora caninum calcium-dependent protein kinase 1 is an effective drug target for neosporosis therapy. PLoS ONE, 9(3), e92929. Public Library of Science 10.1371/journal.pone.0092929


Hemphill, Andrew; Debache, Karim; Monney, Thierry; Schorer, Michelle; Gouinaud, Christophe; Alaeddine, Ferial; Müller, Norbert; Müller, Joachim (2013). Proteins mediating the Neospora caninum-host cell interaction as targets for vaccination. Frontiers in Bioscience (Elite Edition), 5, pp. 23-36. Frontiers in Bioscience

Müller, Joachim; Schildknecht, Patricia; Müller, Norbert (2013). Metabolism of nitro drugs metronidazole and nitazoxanide in Giardia lamblia: characterization of a novel nitroreductase (GlNR2). Journal of antimicrobial chemotherapy, 68(8), pp. 1781-1789. Oxford University Press 10.1093/jac/dkt106

Hemphill, Andrew; Müller, Norbert; Müller, Joachim (2013). Thiazolides, a Novel Class of Anti-Infective Drugs, Effective Against Viruses, Bacteria, Intracellular and Extracellular Protozoan Parasites and Proliferating Mammalian Cells. Anti-infective agents in medicinal chemistry, 11(1), pp. 22-30. Bentham Science 10.2174/22113626130103


Reinmann, Karin; Müller, Norbert; Kuhnert, Peter; Campero, Carlos M.; Leitsch, David; Hess, M; Henning, K; Fort, M; Müller, Joachim; Gottstein, Bruno; Frey, Caroline (2012). Tritrichomonas foetus isolates from cats and cattle show minor genetic differences in unrelated loci ITS-2 and EF-1alpha. Veterinary parasitology, 185(2-4), pp. 138-44. Amsterdam: Elsevier 10.1016/j.vetpar.2011.09.032


Nillius, Dorothea; Müller, Joachim; Müller, Norbert (2011). Nitroreductase (GlNR1) increases susceptibility of Giardia lamblia and Escherichia coli to nitro drugs. Journal of antimicrobial chemotherapy, 66(5), pp. 1029-35. Oxford: Oxford University Press 10.1093/jac/dkr029


Schmuckli-Maurer, Jacqueline; Casanova, Carlo; Schmied, Stéfanie; Affentranger, Sarah; Parvanova, Iana; Kang'a, Simon; Nene, Vishvanath; Katzer, Frank; McKeever, Declan; Müller, Joachim; Bishop, Richard; Pain, Arnab; Dobbelaere, Dirk; Rodrigues, Mauricio Martins (2009). Expression Analysis of the Theileria parva Subtelomere-Encoded Variable Secreted Protein Gene Family. PLoS ONE, 4(3), e4839. Lawrence, Kans.: Public Library of Science 10.1371/journal.pone.0004839

Müller, Joachim; Nillius, Dorothea; Hehl, A.; Hemphill, Andrew; Müller, Norbert (2009). Stable expression of Escherichia coli beta-glucuronidase A (GusA) in Giardia lamblia: application to high-throughput drug susceptibility testing. Journal of antimicrobial chemotherapy, 64(6), pp. 1187-1191. Oxford: Oxford University Press 10.1093/jac/dkp363


Müller, Joachim; Ley, Serej; Felger, Ingrid; Hemphill, Andrew; Müller, Norbert (2008). Identification of differentially expressed genes in a Giardia lamblia WB C6 clone resistant to nitazoxanide and metronidazole. Journal of antimicrobial chemotherapy, 62(1), pp. 72-82. Oxford University Press 10.1093/jac/dkn142


Hemphill, Andrew; Spicher, Martin; Lundström-Stadelmann, Britta; Müller, Joachim; Naguleswaran, Arunasalam; Gottstein, Bruno; Walker, M (2007). Innovative chemotherapeutical treatment options for alveolar and cystic echinococcosis. Parasitology, 134(Pt 12), pp. 1657-70. London: Cambridge University Press 10.1017/S0031182007003198

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