Ruggli, Nicolas

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2019

Xie, Jiexiong; Trus, Ivan; Oh, Dayoung; Kvisgaard, Lise K; Rappe, Julie C.F.; Ruggli, Nicolas; Vanderheijden, Nathalie; Larsen, Lars E; Lefèvre, François; Nauwynck, Hans J (2019). A Triple Amino Acid Substitution at Position 88/94/95 in Glycoprotein GP2a of Type 1 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV1) Is Responsible for Adaptation to MARC-145 Cells. Viruses, 11(1) Molecular Diversity Preservation International MDPI 10.3390/v11010036

2018

Rappe, Julie Christiane Françoise; de Wilde, Adriaan; Di, Han; Müller, Christin; Stalder, Hanspeter; V'Kovski, Philip; Snijder, Eric; Brinton, Margo A; Ziebuhr, John; Ruggli, Nicolas; Thiel, Volker Earl (2018). Antiviral activity of K22 against members of the order Nidovirales. Virus research, 246, pp. 28-34. Elsevier 10.1016/j.virusres.2018.01.002

2017

Demoulins, Thomas; Ebensen, Thomas; Schulze, Kai; Englezou, Pavlos; Pelliccia, Maria; Guzmán, Carlos A; Ruggli, Nicolas; McCullough, Kenneth (2017). Self-replicating RNA vaccine functionality modulated by fine-tuning of polyplex delivery vehicle structure. Journal of controlled release, 266, pp. 256-271. Elsevier 10.1016/j.jconrel.2017.09.018

Ricklin, Meret; Python, Sylvie; Vielle, Nathalie Jane; Brechbühl, Daniel; Zumkehr, Béatrice; Posthaus, Horst; Zimmer, Gert; Ruggli, Nicolas; Summerfield, Artur (2017). Virus replicon particle vaccines expressing nucleoprotein of influenza A virus mediate enhanced inflammatory responses in pigs. Scientific Reports, 7(1), p. 16379. Nature Publishing Group 10.1038/s41598-017-16419-w

Coronado, Liani; Liniger, Matthias; Muñoz-González, Sara; Postel, Alexander; Pérez, Lester Josue; Pérez-Simó, Marta; Perera, Carmen Laura; Frías-Lepoureau, Maria Teresa; Rosell, Rosa; Grundhoff, Adam; Indenbirken, Daniela; Alawi, Malik; Fischer, Nicole; Becher, Paul; Ruggli, Nicolas; Ganges, Llilianne (2017). Novel poly-uridine insertion in the 3'UTR and E2 amino acid substitutions in a low virulent classical swine fever virus. Veterinary microbiology, 201, pp. 103-112. Elsevier 10.1016/j.vetmic.2017.01.013

Demoulins, Thomas; Englezou, Pavlos; Milona, Panagiota; Ruggli, Nicolas; Tirelli, Nicola; Pichon, Chantal; Sapet, Cédric; Ebensen, Thomas; Guzmán, Carlos A; McCullough, Kenneth (2017). Self-Replicating RNA Vaccine Delivery to Dendritic Cells. In: RNA Vaccines. Methods in molecular biology: Vol. 1499 (pp. 37-75). Springer 10.1007/978-1-4939-6481-9_3

2016

Auray, Gael; Keller, Irene; Python, Sylvie; Gerber, Markus Daniel; Bruggmann, Rémy; Ruggli, Nicolas; Summerfield, Artur (2016). Characterization and Transcriptomic Analysis of Porcine Blood Conventional and Plasmacytoid Dendritic Cells Reveals Striking Species-Specific Differences. Journal of immunology, 197(12), pp. 4791-4806. American Association of Immunologists 10.4049/jimmunol.1600672

Rappe, Julie Christiane Françoise; Garcia Nicolas, Obdulio; Flückiger, Franziska; Thür, Barbara; Hofmann, Martin A; Summerfield, Artur; Ruggli, Nicolas (2016). Heterogeneous antigenic properties of the porcine reproductive and respiratory syndrome virus nucleocapsid. Veterinary research, 47(1), p. 117. Editions scientifiques Elsevier 10.1186/s13567-016-0399-9

Gottipati, Keerthi; Holthauzen, Luis Marcelo F; Ruggli, Nicolas; Choi, Kyung H (2016). Pestivirus Npro Directly Interacts with Interferon Regulatory Factor 3 Monomer and Dimer. Journal of virology, 90(17), pp. 7740-7747. American Society for Microbiology 10.1128/JVI.00318-16

Bolz, Miriam; Ruggli, Nicolas; Borel, Nicole; Pluschke, Gerd; Ruf, Marie-Thérèse (2016). Local Cellular Immune Responses and Pathogenesis of Buruli Ulcer Lesions in the Experimental Mycobacterium Ulcerans Pig Infection Model. PLoS neglected tropical diseases, 10(4), e0004678. Public Library of Science 10.1371/journal.pntd.0004678

Eck, Melanie; Durán, Margarita García; Ricklin, Meret; Locher, Samira; Sarraseca, Javier; Rodríguez, María José; McCullough, Kenneth; Summerfield, Artur; Zimmer, Gert; Ruggli, Nicolas (2016). Virus replicon particles expressing porcine reproductive and respiratory syndrome virus proteins elicit immune priming but do not confer protection from viremia in pigs. Veterinary research, 47(33), p. 33. BioMed Central 10.1186/s13567-016-0318-0

Garcia Nicolas, Obdulio; Auray, Gael; Sautter, Carmen Alexandra Nadine; Rappe, Julie Christiane Françoise; McCullough, Kenneth; Ruggli, Nicolas; Summerfield, Artur (2016). Sensing of Porcine Reproductive and Respiratory Syndrome Virus-Infected Macrophages by Plasmacytoid Dendritic Cells. Frontiers in Microbiology, 7(771), p. 771. Frontiers 10.3389/fmicb.2016.00771

2015

Demoulins, Thomas; Milona, Panagiota; Englezou, Pavlos; Ebensen, Thomas; Schulze, Kai; Suter, Rolf; Pichon, Chantal; Midoux, Patrick; Guzmán, Carlos A; Ruggli, Nicolas; McCullough, Kenneth (2015). Polyethylenimine-based polyplex delivery of self-replicating RNA vaccines. Nanomedicine : nanotechnology, biology, and medicine, 12(3), pp. 711-722. Elsevier 10.1016/j.nano.2015.11.001

Tamura, Tomokazu; Ruggli, Nicolas; Nagashima, Naofumi; Okamatsu, Masatoshi; Igarashi, Manabu; Mine, Junki; Hofmann, Martin A; Liniger, Matthias; Summerfield, Artur; Kida, Hiroshi; Sakoda, Yoshihiro (2015). Intracellular membrane association of the N-terminal domain of classical swine fever virus NS4B determines viral genome replication and virulence. Journal of general virology, 96(9), pp. 2623-2635. Society for General Microbiology 10.1099/vir.0.000200

Mine, Junki; Tamura, Tomokazu; Mitsuhashi, Kazuya; Okamatsu, Masatoshi; Parchariyanon, Sujira; Pinyochon, Wasana; Ruggli, Nicolas; Tratschin, Jon-Duri; Kida, Hiroshi; Sakoda, Yoshihiro (2015). The N-terminal domain of Npro of classical swine fever virus determines its stability and regulates type I IFN production. Journal of general virology, 96(Pt 7), pp. 1746-1756. Society for General Microbiology 10.1099/vir.0.000132

Summerfield, Artur; Ruggli, Nicolas (2015). Immune Responses Against Classical Swine Fever Virus: Between Ignorance and Lunacy. Frontiers in veterinary science, 2, p. 10. Frontiers Media 10.3389/fvets.2015.00010

Muñoz-González, Sara; Perez-Simó, Marta; Muñoz, Marta; Bohorquez, José Alejandro; Rosell, Rosa; Summerfield, Artur; Domingo, Mariano; Ruggli, Nicolas; Ganges, Llilianne (2015). Efficacy of a live attenuated vaccine in classical swine fever virus postnatally persistently infected pigs. Veterinary research, 46, p. 78. Editions scientifiques Elsevier 10.1186/s13567-015-0209-9

Muñoz-González, Sara; Ruggli, Nicolas; Rosell, Rosa; Pérez, Lester Josué; Frías-Leuporeau, Maria Teresa; Fraile, Lorenzo; Montoya, Maria; Cordoba, Lorena; Domingo, Mariano; Ehrensperger, Felix; Summerfield, Artur; Ganges, Llilianne (2015). Postnatal persistent infection with classical Swine Fever virus and its immunological implications. PLoS ONE, 10(5), e0125692. Public Library of Science 10.1371/journal.pone.0125692

2014

Mokhtar, Helen; Eck, Melanie; Morgan, Sophie B; Essler, Sabine E; Frossard, Jean-Pierre; Ruggli, Nicolas; Graham, Simon P (2014). Proteome-wide screening of the European porcine reproductive and respiratory syndrome virus reveals a broad range of T cell antigen reactivity. Vaccine, 32(50), pp. 6828-6837. Elsevier 10.1016/j.vaccine.2014.04.054

McCullough, Kenneth C.; Milona, Panagiota; Thomann-Harwood, Lisa; Demoulins, Thomas; Englezou, Pavlos; Suter, Rolf; Ruggli, Nicolas (2014). Self-Amplifying Replicon RNA Vaccine Delivery to Dendritic Cells by Synthetic Nanoparticles. Vaccines, 2(4), pp. 735-754. MDPI 10.3390/vaccines2040735

Bolz, Miriam; Ruggli, Nicolas; Ruf, Marie-Thérèse; Ricklin, Meret E; Zimmer, Gert; Pluschke, Gerd (2014). Experimental infection of the pig with Mycobacterium ulcerans: a novel model for studying the pathogenesis of Buruli ulcer disease. PLoS neglected tropical diseases, 8(7), e2968. Public Library of Science 10.1371/journal.pntd.0002968

Gottipati, Keerthi; Acholi, Sudheer; Ruggli, Nicolas; Choi, Kyung H (2014). Autocatalytic activity and substrate specificity of the pestivirus N-terminal protease Npro. Virology, 452-453, pp. 303-309. Academic Press 10.1016/j.virol.2014.01.026

McCullough, Kenneth C; Bassi, Isabelle; Milona, Panagiota; Suter, Rolf; Thomann-Harwood, Lisa; Englezou, Pavlos; Demoulins, Thomas; Ruggli, Nicolas (2014). Self-replicating Replicon-RNA Delivery to Dendritic Cells by Chitosan-nanoparticles for Translation In Vitro and In Vivo. Molecular Therapy - Nucleic Acids, 3, e173. Nature Publishing Group 10.1038/mtna.2014.24

Tamura, Tomokazu; Nagashima, Naofumi; Ruggli, Nicolas; Summerfield, Artur; Kida, Hiroshi; Sakoda, Yoshihiro (2014). Npro of classical swine fever virus contributes to pathogenicity in pigs by preventing type I interferon induction at local replication sites. Veterinary research, 45, p. 47. Biomed Central 10.1186/1297-9716-45-47

2013

Leifer, Immanuel; Ruggli, Nicolas; Blome, Sandra (2013). Approaches to define the viral genetic basis of classical swine fever virus virulence. Virology, 438(2), pp. 51-55. Academic Press 10.1016/j.virol.2013.01.013

2006

Frey, Caroline; Bauhofer, Oliver; Ruggli, Nicolas; Summerfield, Artur; Hofmann, Martin A; Tratschin, Jon-Duri (2006). Classical swine fever virus replicon particles lacking the Erns gene: a potential marker vaccine for intradermal application. Veterinary research, 37(5), pp. 655-670. Editions scientifiques Elsevier 10.1051/vetres:2006028

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