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Eggel, Alexander; Pennington, Luke F; Jardetzky, Theodore S (2024). Therapeutic monoclonal antibodies in allergy: Targeting IgE, cytokine, and alarmin pathways. (In Press). Immunological reviews Wiley-Blackwell 10.1111/imr.13380
Brigger, Daniel; Guntern, Pascal; Jonsdottir, Hulda R; Pennington, Luke F; Weber, Benjamin; Taddeo, Adriano; Zimmer, Gert; Leborgne, Nathan G F; Benarafa, Charaf; Jardetzky, Theodore S; Eggel, Alexander (2023). Sex-specific differences in immune response to SARS-CoV-2 vaccination vanish with age. Allergy, 78(6), pp. 1683-1686. Wiley 10.1111/all.15652
Pennington, Luke F; Gasser, Pascal; Kleinboelting, Silke; Zhang, Chensong; Skiniotis, Georgios; Eggel, Alexander; Jardetzky, Theodore S (2021). Directed evolution of and structural insights into antibody-mediated disruption of a stable receptor-ligand complex. Nature Communications, 12(1), p. 7069. Springer Nature 10.1038/s41467-021-27397-z
Pennington, Luke F; Gasser, Pascal; Brigger, Daniel; Guntern, Pascal; Eggel, Alexander; Jardetzky, Theodore S (2021). Structure-guided design of ultrapotent disruptive IgE inhibitors to rapidly terminate acute allergic reactions. Journal of allergy and clinical immunology, 148(4), pp. 1049-1060. Elsevier 10.1016/j.jaci.2021.03.050
Gasser, Pascal; Tarchevskaya, Svetlana S; Guntern, Pascal Martin; Brigger, Daniel; Ruppli, Rahel; Zbären, Noemi; Kleinboelting, Silke; Heusser, Christoph; Jardetzky, Theodore S; Eggel, Alexander (2020). The mechanistic and functional profile of the therapeutic anti-IgE antibody ligelizumab differs from omalizumab. Nature Communications, 11(1), p. 165. Springer Nature 10.1038/s41467-019-13815-w
Pennington, Luke F; Tarchevskaya, Svetlana; Brigger, Daniel; Sathiyamoorthy, Karthik; Graham, Michelle T; Nadeau, Kari Christine; Eggel, Alexander; Jardetzky, Theodore S (2016). Structural basis of omalizumab therapy and omalizumab-mediated IgE exchange. Nature communications, 7(11610), p. 11610. Nature Publishing Group 10.1038/ncomms11610
Kim, Beomkyu; Eggel, Alexander; Tarchevskaya, Svetlana S; Vogel, Monique; Prinz, Heino; Jardetzky, Theodore S (2012). Accelerated disassembly of IgE-receptor complexes by a disruptive macromolecular inhibitor. Nature, 491(7425), pp. 613-7. London: Macmillan Journals Ltd. 10.1038/nature11546
Kim, Beomkyu; Tarchevskaya, Svetlana S; Eggel, Alexander; Vogel, Monique; Jardetzky, Theodore S (2012). A time-resolved fluorescence resonance energy transfer assay suitable for high-throughput screening for inhibitors of immunoglobulin E-receptor interactions. Analytical biochemistry, 431(2), pp. 84-9. San Diego, Calif.: Elsevier 10.1016/j.ab.2012.09.010
Wurzburg, Beth A; Kim, Beomkyu; Tarchevskaya, Svetlana S; Eggel, Alexander; Vogel, Monique; Jardetzky, Theodore S (2012). An engineered disulfide bond reversibly traps the IgE-Fc3-4 in a closed, nonreceptor binding conformation. Journal of biological chemistry, 287(43), pp. 36251-7. Bethesda, Md.: American Society for Biochemistry and Molecular Biology 10.1074/jbc.M112.407502
