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Bonvin, Etienne; Personne, Hippolyte; Paschoud, Thierry; Reusser, Jérémie; Gan, Bee-Ha; Luscher, Alexandre; Köhler, Thilo; van Delden, Christian; Reymond, Jean-Louis (2023). Antimicrobial Peptide-Peptoid Hybrids with and without Membrane Disruption. ACS infectious diseases, 9(12), pp. 2593-2606. American Chemical Society 10.1021/acsinfecdis.3c00421
Personne, Hippolyte; Paschoud, Thierry; Fulgencio, Sofia; Baeriswyl, Stéphane; Köhler, Thilo; van Delden, Christian; Stocker, Achim; Javor, Sacha; Reymond, Jean-Louis (2023). To Fold or Not to Fold: Diastereomeric Optimization of an α-Helical Antimicrobial Peptide. Journal of medicinal chemistry, 66(11), pp. 7570-7583. American Chemical Society 10.1021/acs.jmedchem.3c00460
Cai, Xingguang; Orsi, Markus; Capecchi, Alice; Köhler, Thilo; van Delden, Christian; Javor, Sacha; Reymond, Jean-Louis (2022). An intrinsically disordered antimicrobial peptide dendrimer from stereorandomized virtual screening. Cell reports. Physical science, 3(12), pp. 1-15. Cell Press 10.1016/j.xcrp.2022.101161
Baeriswyl, Stéphane; Personne, Hippolyte; Di Bonaventura, Ivan; Köhler, Thilo; van Delden, Christian; Stocker, Achim; Javor, Sacha; Reymond, Jean-Louis (2021). A mixed chirality α-helix in a stapled bicyclic and a linear antimicrobial peptide revealed by X-ray crystallography. RSC chemical biology, 2(6), pp. 1608-1617. Royal Society of Chemistry 10.1039/D1CB00124H
Jafari, Paris; Luscher, Alexandre; Siriwardena, Thissa; Michetti, Murielle; Que, Yok-Ai; Rahme, Laurence G.; Reymond, Jean-Louis; Raffoul, Wassim; Van Delden, Christian; Applegate, Lee Ann; Köhler, Thilo (2021). Antimicrobial Peptide Dendrimers and Quorum-Sensing Inhibitors in Formulating Next-Generation Anti-Infection Cell Therapy Dressings for Burns. Molecules, 26(13), p. 3839. MDPI 10.3390/molecules26133839
Capecchi, Alice; Cai, Xingguang; Personne, Hippolyte; Köhler, Thilo; van Delden, Christian; Reymond, Jean-Louis (2021). Machine learning designs non-hemolytic antimicrobial peptides. Chemical Science, 12(26), pp. 9221-9232. The Royal Society of Chemistry 10.1039/D1SC01713F
Cai, Xingguang; Javor, Sacha; Gan, Bee Ha; Köhler, Thilo; Reymond, Jean-Louis (2021). The antibacterial activity of peptide dendrimers and polymyxin B increases sharply above pH 7.4. Chemical communications, 57(46), pp. 5654-5657. Royal Society of Chemistry 10.1039/D1CC01838H
Siriwardena, Thissa N.; Gan, Bee-Ha; Köhler, Thilo; van Delden, Christian; Javor, Sacha; Reymond, Jean-Louis (2021). Stereorandomization as a Method to Probe Peptide Bioactivity. ACS central science, 7(1), pp. 126-134. ACS Publications 10.1021/acscentsci.0c01135
Gan, Bee-Ha; Cai, Xingguang; Javor, Sacha; Köhler, Thilo; Reymond, Jean-Louis (2020). Synergistic Effect of Propidium Iodide and Small Molecule Antibiotics with the Antimicrobial Peptide Dendrimer G3KL against Gram-Negative Bacteria. Molecules, 25(23), p. 5643. MDPI 10.3390/molecules25235643
Ben Jeddou, Fatma; Falconnet, Léna; Luscher, Alexandre; Siriwardena, Thissa; Reymond, Jean-Louis; van Delden, Christian; Köhler, Thilo (2020). Adaptive and Mutational Responses to Peptide Dendrimer Antimicrobials in Pseudomonas aeruginosa. Antimicrobial agents and chemotherapy, 64(4) American Society for Microbiology 10.1128/AAC.02040-19
Siriwardena, Thissa N.; Lüscher, Alexandre; Köhler, Thilo; van Delden, Christian; Javor, Sacha; Reymond, Jean-Louis (2019). Antimicrobial Peptide Dendrimer Chimera. Helvetica chimica acta, 102(4), e1900034. Wiley 10.1002/hlca.201900034
Siriwardena, Thissa N.; Capecchi, Alice; Gan, Bee-Ha; Jin, Xian; He, Runze; Wei, Dengwen; Ma, Lan; Köhler, Thilo; van Delden, Christian; Javor, Sacha; Reymond, Jean-Louis (2018). Optimizing Antimicrobial Peptide Dendrimers in Chemical Space. Angewandte Chemie (International ed.), 57(28), pp. 8483-8487. Wiley-VCH 10.1002/anie.201802837
Di Bonaventura, Ivan; Baeriswyl, Stéphane; Capecchi, Alice; Gan, Bee-Ha; Jin, Xian; Siriwardena, Thissa N.; He, Runze; Köhler, Thilo; Pompilio, Arianna; Di Bonaventura, Giovanni; van Delden, Christian; Javor, Sacha; Reymond, Jean-Louis (2018). An antimicrobial bicyclic peptide from chemical space against multidrug resistant Gram-negative bacteria. Chemical communications, 54(40), pp. 5130-5133. Royal Society of Chemistry 10.1039/C8CC02412J
Di Bonaventura, Ivan; Jin, Xian; Visini, Ricardo; Probst, Daniel; Javor, Sacha; Gan, Bee-Ha; Michaud, Gaëlle; Natalello, Antonino; Doglia, Silvia Maria; Köhler, Thilo; van Delden, Christian; Stocker, Achim; Darbre, Tamis; Reymond, Jean-Louis (2017). Chemical space guided discovery of antimicrobial bridged bicyclic peptides against Pseudomonas aeruginosa and its biofilms. Chemical Science, 8(10), pp. 6784-6798. The Royal Society of Chemistry 10.1039/C7SC01314K
He, Runze; Di Bonaventura, Ivan; Visini, Ricardo; Gan, Bee-Ha; Fu, Yongchun; Probst, Daniel; Lüscher, Alexandre; Köhler, Thilo; van Delden, Christian; Stocker, Achim; Hong, Wenjing; Darbre, Tamis; Reymond, Jean-Louis (2017). Design, crystal structure and atomic force microscopy study of thioether ligated d , l -cyclic antimicrobial peptides against multidrug resistant Pseudomonas aeruginosa. Chemical Science, 8(11), pp. 7464-7475. The Royal Society of Chemistry 10.1039/C7SC01599B
Stach, Michaela; Siriwardena, Thissa; Köhler, Thilo; van Delden, Christian; Darbre, Tamis; Reymond, Jean-Louis (2014). Combining Topology and Sequence Design for the Discovery of Potent Antimicrobial Peptide Dendrimers against Multidrug-Resistant Pseudomonas aeruginosa. Angewandte Chemie (International ed.), 53(47), pp. 12827-12831. Wiley-VCH 10.1002/anie.201409270
