Proulx, Steven T

Madarasz, Adrian; Xin, Li; Proulx, Steven T (2024). Clearance of erythrocytes from the subarachnoid space through cribriform plate lymphatics in female mice. EBioMedicine, 107(105295), p. 105295. Elsevier 10.1016/j.ebiom.2024.105295

Sáinz-Jaspeado, Miguel; Proulx, Steven T; Ring, Sarah; Richards, Mark; Martinsson, Pernilla; Li, Xiujuan; Claesson-Welsh, Lena; Ulvmar, Maria H; Jin, Yi (2024). VE-cadherin junction dynamics in initial lymphatic vessels promotes lymph node metastasis. Life science alliance, 7(3) EMBO Press 10.26508/lsa.202302168

Kelly, Louise; Brown, Christopher; Michalik, Daniel; Hawkes, Cheryl A; Aldea, Roxana; Agarwal, Nivedita; Salib, Rami; Alzetani, Aiman; Ethell, Douglas W; Counts, Scott E; de Leon, Mony; Fossati, Silvia; Koronyo-Hamaoui, Maya; Piazza, Fabrizio; Rich, Steven A; Wolters, Frank J; Snyder, Heather; Ismail, Ozama; Elahi, Fanny; Proulx, Steven T; ... (2024). Clearance of interstitial fluid (ISF) and CSF (CLIC) group-part of Vascular Professional Interest Area (PIA), updates in 2022-2023. Cerebrovascular disease and the failure of elimination of Amyloid-β from the brain and retina with age and Alzheimer's disease: Opportunities for therapy. Alzheimer's & dementia : the journal of the Alzheimer's Association, 20(2), pp. 1421-1435. 10.1002/alz.13512

Pietilä, Riikka; Del Gaudio, Francesca; He, Liqun; Vázquez-Liébanas, Elisa; Vanlandewijck, Michael; Muhl, Lars; Mocci, Giuseppe; Bjørnholm, Katrine D; Lindblad, Caroline; Fletcher-Sandersjöö, Alexander; Svensson, Mikael; Thelin, Eric P; Liu, Jianping; van Voorden, A Jantine; Torres, Monica; Antila, Salli; Xin, Li; Karlström, Helena; Storm-Mathisen, Jon; Bergersen, Linda Hildegard; ... (2023). Molecular anatomy of adult mouse leptomeninges. Neuron, 111(23), 3745-3764.e7. Elsevier 10.1016/j.neuron.2023.09.002

Mapunda, Josephine A; Pareja, Javier; Vladymyrov, Mykhailo; Bouillet, Elisa; Hélie, Pauline; Pleskač, Petr; Barcos, Sara; Andrae, Johanna; Vestweber, Dietmar; McDonald, Donald M; Betsholtz, Christer; Deutsch, Urban; Proulx, Steven T; Engelhardt, Britta (2023). VE-cadherin in arachnoid and pia mater cells serves as a suitable landmark for in vivo imaging of CNS immune surveillance and inflammation. Nature communications, 14(1), p. 5837. Nature Publishing Group 10.1038/s41467-023-41580-4

Spera, Irene; Cousin, Nikola; Ries, Miriam; Kedracka, Anna; Castillo, Alina; Aleandri, Simone; Vladymyrov, Mykhailo; Mapunda, Josephine A; Engelhardt, Britta; Luciani, Paola; Detmar, Michael; Proulx, Steven T (2023). Open pathways for cerebrospinal fluid outflow at the cribriform plate along the olfactory nerves. EBioMedicine, 91(104558), p. 104558. Elsevier 10.1016/j.ebiom.2023.104558

Proulx, Steven T; Engelhardt, Britta (2023). Macrophages clear the way for CNS fluid flow. The lancet. Neurology, 22(3), pp. 194-195. Elsevier 10.1016/S1474-4422(23)00028-5

Proulx, Steven T (2023). The peri-olfactory pathway: An "e-scent-ial" route for cerebrospinal fluid clearance? EBioMedicine, 87(104417), p. 104417. Elsevier 10.1016/j.ebiom.2022.104417

Ineichen, Benjamin V; Okar, Serhat V; Proulx, Steven T; Engelhardt, Britta; Lassmann, Hans; Reich, Daniel S (2022). Perivascular spaces and their role in neuroinflammation. Neuron, 110(21), pp. 3566-3581. Cell Press 10.1016/j.neuron.2022.10.024

Friess, Mona C; Kritikos, Ioannis; Schineis, Philipp; Medina-Sanchez, Jessica Danielly; Gkountidi, Anastasia-Olga; Vallone, Angela; Sigmund, Elena C; Schwitter, Corina; Vranova, Martina; Matti, Christoph; Arasa, Jorge; Saygili Demir, Cansaran; Bovay, Esther; Proulx, Steven T; Tomura, Michio; Rot, Antal; Legler, Daniel F; Petrova, Tatiana V; Halin, Cornelia (2022). Mechanosensitive ACKR4 scavenges CCR7 chemokines to facilitate T cell de-adhesion and passive transport by flow in inflamed afferent lymphatics. Cell reports, 38(5), p. 110334. Cell Press 10.1016/j.celrep.2022.110334

Dieterich, Lothar C; Tacconi, Carlotta; Menzi, Franziska; Proulx, Steven T; Kapaklikaya, Kübra; Hamada, Michito; Takahashi, Satoru; Detmar, Michael (2020). Lymphatic MAFB regulates vascular patterning during developmental and pathological lymphangiogenesis. Angiogenesis, 23(3), pp. 411-423. Springer Netherlands 10.1007/s10456-020-09721-1

Gousopoulos, Epameinondas; Proulx, Steven T; Bachmann, Samia B; Dieterich, Lothar C; Scholl, Jeannette; Karaman, Sinem; Bianchi, Roberta; Detmar, Michael (2017). An Important Role of VEGF-C in Promoting Lymphedema Development. Journal of investigative dermatology, 137(9), pp. 1995-2004. Elsevier 10.1016/j.jid.2017.04.033

Teijeira, Alvaro; Hunter, Morgan C; Russo, Erica; Proulx, Steven T; Frei, Thomas; Debes, Gudrun F; Coles, Marc; Melero, Ignacio; Detmar, Michael; Rouzaut, Ana; Halin, Cornelia (2017). T Cell Migration from Inflamed Skin to Draining Lymph Nodes Requires Intralymphatic Crawling Supported by ICAM-1/LFA-1 Interactions. Cell reports, 18(4), pp. 857-865. Cell Press 10.1016/j.celrep.2016.12.078

Proulx, Steven T; Ma, Qiaoli; Andina, Diana; Leroux, Jean-Christophe; Detmar, Michael (2017). Quantitative measurement of lymphatic function in mice by noninvasive near-infrared imaging of a peripheral vein. JCI insight, 2(1), pp. 1-13. JCI Insight 10.1172/jci.insight.90861

Cui, Jihong; Hollmén, Maija; Li, Lina; Chen, Yong; Proulx, Steven T; Reker, Daniel; Schneider, Gisbert; Detmar, Michael (2017). New use of an old drug: inhibition of breast cancer stem cells by benztropine mesylate. OncoTarget, 8(1), pp. 1007-1022. Impact Journals LLC 10.18632/oncotarget.13537

Bianchi, Roberta; Russo, Erica; Bachmann, Samia B; Proulx, Steven T; Sesartic, Marko; Smaadahl, Nora; Watson, Steve P; Buckley, Christopher D; Halin, Cornelia; Detmar, Michael (2017). Postnatal Deletion of Podoplanin in Lymphatic Endothelium Results in Blood Filling of the Lymphatic System and Impairs Dendritic Cell Migration to Lymph Nodes. Arteriosclerosis, thrombosis, and vascular biology, 37(1), pp. 108-117. American Heart Association 10.1161/ATVBAHA.116.308020

Gousopoulos, Epameinondas; Karaman, Sinem; Proulx, Steven T; Leu, Kristin; Buschle, Dorina; Detmar, Michael (2017). High-Fat Diet in the Absence of Obesity Does Not Aggravate Surgically Induced Lymphoedema in Mice. European surgical research, 58(3-4), pp. 180-192. Karger 10.1159/000461579

Gousopoulos, Epameinondas; Proulx, Steven T; Bachmann, Samia B; Scholl, Jeannette; Dionyssiou, Dimitris; Demiri, Efterpi; Halin, Cornelia; Dieterich, Lothar C; Detmar, Michael (2016). Regulatory T cell transfer ameliorates lymphedema and promotes lymphatic vessel function. JCI insight, 1(16), pp. 1-15. JCI Insight 10.1172/jci.insight.89081

Ochsenbein, Alexandra M; Karaman, Sinem; Proulx, Steven T; Goldmann, Rhea; Chittazhathu, Jyothi; Dasargyri, Athanasia; Chong, Chloé; Leroux, Jean-Christophe; Stanley, E Richard; Detmar, Michael (2016). Regulation of lymphangiogenesis in the diaphragm by macrophages and VEGFR-3 signaling. Angiogenesis, 19(4), pp. 513-524. Springer Netherlands 10.1007/s10456-016-9523-8

Gousopoulos, Epameinondas; Proulx, Steven T; Scholl, Jeannette; Uecker, Maja; Detmar, Michael (2016). Prominent Lymphatic Vessel Hyperplasia with Progressive Dysfunction and Distinct Immune Cell Infiltration in Lymphedema. American journal of pathology, 186(8), pp. 2193-2203. Elsevier 10.1016/j.ajpath.2016.04.006

Christiansen, Ailsa J; Dieterich, Lothar C; Ohs, Isabel; Bachmann, Samia B; Bianchi, Roberta; Proulx, Steven T; Hollmén, Maija; Aebischer, David; Detmar, Michael (2016). Lymphatic endothelial cells attenuate inflammation via suppression of dendritic cell maturation. OncoTarget, 7(26), pp. 39421-39435. Impact Journals LLC 10.18632/oncotarget.9820

Chong, Chloé; Scholkmann, Felix; Bachmann, Samia B; Luciani, Paola; Leroux, Jean-Christophe; Detmar, Michael; Proulx, Steven T (2016). In vivo visualization and quantification of collecting lymphatic vessel contractility using near-infrared imaging. Scientific Reports, 6, p. 22930. Nature Publishing Group 10.1038/srep22930

Dasargyri, Athanasia; Hervella, Pablo; Christiansen, Ailsa; Proulx, Steven T; Detmar, Michael; Leroux, Jean-Christophe (2016). Findings questioning the involvement of Sigma-1 receptor in the uptake of anisamide-decorated particles. Journal of controlled release, 224, pp. 229-238. Elsevier 10.1016/j.jconrel.2016.01.021

Brambilla, Davide; Proulx, Steven T; Marschalkova, Patrizia; Detmar, Michael; Leroux, Jean-Christophe (2016). Microneedles for the Noninvasive Structural and Functional Assessment of Dermal Lymphatic Vessels. Small, 12(8), pp. 1053-1061. Wiley-VCH 10.1002/smll.201503093

Ochsenbein, Alexandra M; Karaman, Sinem; Proulx, Steven T; Berchtold, Michaela; Jurisic, Giorgia; Stoeckli, Esther T; Detmar, Michael (2016). Endothelial cell-derived semaphorin 3A inhibits filopodia formation by blood vascular tip cells. Development, 143(4), pp. 589-594. Company of Biologists Limited 10.1242/dev.127670

Escobedo, Noelia; Proulx, Steven T; Karaman, Sinem; Dillard, Miriam E; Johnson, Nicole; Detmar, Michael; Oliver, Guillermo (2016). Restoration of lymphatic function rescues obesity in Prox1-haploinsufficient mice. JCI insight, 1(2), pp. 1-17. JCI Insight 10.1172/jci.insight.85096

Karaman, Sinem; Buschle, Dorina; Luciani, Paola; Leroux, Jean-Christophe; Detmar, Michael; Proulx, Steven T (2015). Decline of lymphatic vessel density and function in murine skin during aging. Angiogenesis, 18(4), pp. 489-498. Springer Netherlands 10.1007/s10456-015-9479-0

Aspelund, Aleksanteri; Antila, Salli; Proulx, Steven T; Karlsen, Tine Veronica; Karaman, Sinem; Detmar, Michael; Wiig, Helge; Alitalo, Kari (2015). A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules. The Journal of experimental medicine, 212(7), pp. 991-999. Rockefeller Univ. Press 10.1084/jem.20142290

Moalli, Federica; Proulx, Steven T; Schwendener, Reto; Detmar, Michael; Schlapbach, Christoph; Stein, Jens Volker (2015). Intravital and whole-organ imaging reveals capture of melanoma-derived antigen by lymph node subcapsular macrophages leading to widespread deposition on follicular dendritic cells. Frontiers in immunology, 6(114), p. 114. Frontiers Research Foundation 10.3389/fimmu.2015.00114

Bianchi, Roberta; Teijeira, Alvaro; Proulx, Steven T; Christiansen, Ailsa J; Seidel, Catharina D; Rülicke, Thomas; Mäkinen, Taija; Hägerling, René; Halin, Cornelia; Detmar, Michael (2015). A transgenic Prox1-Cre-tdTomato reporter mouse for lymphatic vessel research. PLoS ONE, 10(4), e0122976. Public Library of Science 10.1371/journal.pone.0122976

Blum, Katrin S; Karaman, Sinem; Proulx, Steven T; Ochsenbein, Alexandra M; Luciani, Paola; Leroux, Jean-Christophe; Wolfrum, Christian; Detmar, Michael (2014). Chronic high-fat diet impairs collecting lymphatic vessel function in mice. PLoS ONE, 9(4), e94713. Public Library of Science 10.1371/journal.pone.0094713

Proulx, Steven T; Luciani, Paola; Dieterich, Lothar C; Karaman, Sinem; Leroux, Jean-Christophe; Detmar, Michael (2013). Expansion of the lymphatic vasculature in cancer and inflammation: new opportunities for in vivo imaging and drug delivery. Journal of controlled release, 172(2), pp. 550-557. Elsevier 10.1016/j.jconrel.2013.04.027

Iolyeva, Maria; Aebischer, David; Proulx, Steven T; Willrodt, Ann-Helen; Ecoiffier, Tatiana; Häner, Simone; Bouchaud, Grégory; Krieg, Carsten; Onder, Lucas; Ludewig, Burkhard; Santambrogio, Laura; Boyman, Onur; Chen, Lu; Finke, Daniela; Halin, Cornelia (2013). Interleukin-7 is produced by afferent lymphatic vessels and supports lymphatic drainage. Blood, 122(13), pp. 2271-2281. American Society of Hematology 10.1182/blood-2013-01-478073

Alitalo, Annamari K; Proulx, Steven T; Karaman, Sinem; Aebischer, David; Martino, Stefania; Jost, Manuela; Schneider, Nicole; Bry, Maija; Detmar, Michael (2013). VEGF-C and VEGF-D blockade inhibits inflammatory skin carcinogenesis. Cancer research, 73(14), pp. 4212-4221. American Association for Cancer Research AACR 10.1158/0008-5472.CAN-12-4539

Proulx, Steven T; Detmar, Michael (2013). Molecular mechanisms and imaging of lymphatic metastasis. Experimental cell research, 319(11), pp. 1611-1617. Elsevier 10.1016/j.yexcr.2013.03.009

Proulx, Steven T; Luciani, Paola; Christiansen, Ailsa; Karaman, Sinem; Blum, Katrin S; Rinderknecht, Matthias; Leroux, Jean-Christophe; Detmar, Michael (2013). Use of a PEG-conjugated bright near-infrared dye for functional imaging of rerouting of tumor lymphatic drainage after sentinel lymph node metastasis. Biomaterials, 34(21), pp. 5128-5137. Elsevier 10.1016/j.biomaterials.2013.03.034

Proulx, Steven T; Luciani, Paola; Alitalo, Annamari; Mumprecht, Viviane; Christiansen, Ailsa J; Huggenberger, Reto; Leroux, Jean-Christophe; Detmar, Michael (2013). Non-invasive dynamic near-infrared imaging and quantification of vascular leakage in vivo. Angiogenesis, 16(3), pp. 525-540. Springer Netherlands 10.1007/s10456-013-9332-2

Blum, Katrin S; Proulx, Steven T; Luciani, Paola; Leroux, Jean-Christophe; Detmar, Michael (2013). Dynamics of lymphatic regeneration and flow patterns after lymph node dissection. Breast cancer research and treatment, 139(1), pp. 81-86. Springer 10.1007/s10549-013-2537-7

Duong, Tam; Proulx, Steven T; Luciani, Paola; Leroux, Jean-Christophe; Detmar, Michael; Koopman, Peter; Francois, Mathias (2012). Genetic ablation of SOX18 function suppresses tumor lymphangiogenesis and metastasis of melanoma in mice. Cancer research, 72(12), pp. 3105-3114. American Association for Cancer Research AACR 10.1158/0008-5472.CAN-11-4026

Proulx, Steven T; Detmar, Michael (2012). Watching lymphatic vessels grow by making them glow. Cell research, 22(1), pp. 12-13. Nature Publishing Group 10.1038/cr.2011.191

Mumprecht, Viviane; Honer, Michael; Vigl, Benjamin; Proulx, Steven T; Trachsel, Eveline; Kaspar, Manuela; Banziger-Tobler, Nadja E; Schibli, Roger; Neri, Dario; Detmar, Michael (2010). In vivo imaging of inflammation- and tumor-induced lymph node lymphangiogenesis by immuno-positron emission tomography. Cancer research, 70(21), pp. 8842-8851. American Association for Cancer Research AACR 10.1158/0008-5472.CAN-10-0896

Jurisic, Giorgia; Iolyeva, Maria; Proulx, Steven T; Halin, Cornelia; Detmar, Michael (2010). Thymus cell antigen 1 (Thy1, CD90) is expressed by lymphatic vessels and mediates cell adhesion to lymphatic endothelium. Experimental cell research, 316(17), pp. 2982-2992. Elsevier 10.1016/j.yexcr.2010.06.013

Huggenberger, Reto; Ullmann, Stefan; Proulx, Steven T; Pytowski, Bronislaw; Alitalo, Kari; Detmar, Michael (2010). Stimulation of lymphangiogenesis via VEGFR-3 inhibits chronic skin inflammation. The Journal of experimental medicine, 207(10), pp. 2255-2269. Rockefeller Univ. Press 10.1084/jem.20100559

Proulx, Steven T; Luciani, Paola; Derzsi, Stefanie; Rinderknecht, Matthias; Mumprecht, Viviane; Leroux, Jean-Christophe; Detmar, Michael (2010). Quantitative imaging of lymphatic function with liposomal indocyanine green. Cancer research, 70(18), pp. 7053-7062. American Association for Cancer Research AACR 10.1158/0008-5472.CAN-10-0271

Papuga, M Owen; Proulx, Steven T; Kwok, Edmund; You, Zhigang; Rubery, Paul T; Dougherty, Paul E; Hilton, Matthew J; Awad, Hani A; Schwarz, Edward M (2010). Chronic axial compression of the mouse tail segment induces MRI bone marrow edema changes that correlate with increased marrow vasculature and cellularity. Journal of orthopaedic research, 28(9), pp. 1220-1228. Wiley 10.1002/jor.21103

Li, Jie; Kuzin, Igor; Moshkani, Safiehkhatoon; Proulx, Steven T; Xing, Lianping; Skrombolas, Denise; Dunn, Robert; Sanz, Iñaki; Schwarz, Edward M; Bottaro, Andrea (2010). Expanded CD23(+)/CD21(hi) B cells in inflamed lymph nodes are associated with the onset of inflammatory-erosive arthritis in TNF-transgenic mice and are targets of anti-CD20 therapy. Journal of immunology, 184(11), pp. 6142-6150. American Association of Immunologists 10.4049/jimmunol.0903489

Li, Dan; Gromov, Kirill; Proulx, Steven T; Xie, Chao; Li, Jie; Crane, Daniel P; Søballe, Kjeld; O'Keefe, Regis J; Awad, Hani A; Xing, Lianping; Schwarz, Edward M (2010). Effects of antiresorptive agents on osteomyelitis: novel insights into the pathogenesis of osteonecrosis of the jaw. Annals of the New York Academy of Sciences, 1192(1), pp. 84-94. Wiley 10.1111/j.1749-6632.2009.05210.x

Schwarz, Edward M; Proulx, Steven T; Ritchlin, Christopher T; Boyce, Brendan F; Xing, Lianping (2010). The role of bone marrow edema and lymphangiogenesis in inflammatory-erosive arthritis. Advances in experimental medicine and biology, 658, pp. 1-10. Springer 10.1007/978-1-4419-1050-9_1

Guo, Ruolin; Zhou, Quan; Proulx, Steven T; Wood, Ronald; Ji, Rui-Cheng; Ritchlin, Christopher T; Pytowski, Bronislaw; Zhu, Zhenping; Wang, Yong-Jun; Schwarz, Edward M; Xing, Lianping (2009). Inhibition of lymphangiogenesis and lymphatic drainage via vascular endothelial growth factor receptor 3 blockade increases the severity of inflammation in a mouse model of chronic inflammatory arthritis. Arthritis & rheumatism, 60(9), pp. 2666-2676. Wiley-Blackwell 10.1002/art.24764

Ritchlin, Christopher T; Proulx, Steven T; Schwarz, Edward S (2009). Translational perspectives on psoriatic arthritis. The journal of rheumatology. Supplement, 83, pp. 30-34. The Journal of Rheumatology Publishing Company Limited 10.3899/jrheum.090219

Tsutsumi, Ryosuke; Hock, Colleen; Bechtold, C Dustin; Proulx, Steven T; Bukata, Susan V; Ito, Hiromu; Awad, Hani A; Nakamura, Takashi; O'Keefe, Regis J; Schwarz, Edward M (2008). Differential effects of biologic versus bisphosphonate inhibition of wear debris-induced osteolysis assessed by longitudinal micro-CT. Journal of orthopaedic research, 26(10), pp. 1340-1346. Wiley 10.1002/jor.20620

Proulx, Steven T; Kwok, Edmund; You, Zhigang; Papuga, M Owen; Beck, Christopher A; Shealy, David J; Calvi, Laura M; Ritchlin, Christopher T; Awad, Hani A; Boyce, Brendan F; Xing, Lianping; Schwarz, Edward M (2008). Elucidating bone marrow edema and myelopoiesis in murine arthritis using contrast-enhanced magnetic resonance imaging. Arthritis & rheumatism, 58(7), pp. 2019-2029. Wiley-Blackwell 10.1002/art.23546

Proulx, Steven T; Kwok, Edmund; You, Zhigang; Papuga, M Owen; Beck, Christopher A; Shealy, David J; Ritchlin, Christopher T; Awad, Hani A; Boyce, Brendan F; Xing, Lianping; Schwarz, Edward M (2007). Longitudinal assessment of synovial, lymph node, and bone volumes in inflammatory arthritis in mice by in vivo magnetic resonance imaging and microfocal computed tomography. Arthritis & rheumatism, 56(12), pp. 4024-4037. Wiley-Blackwell 10.1002/art.23128

Proulx, Steven T; Kwok, Edmund; You, Zhigang; Beck, Christopher A; Shealy, David J; Ritchlin, Christopher T; Boyce, Brendan F; Xing, Lianping; Schwarz, Edward M (2007). MRI and quantification of draining lymph node function in inflammatory arthritis. Annals of the New York Academy of Sciences, 1117(1), pp. 106-123. Wiley 10.1196/annals.1402.016

Zhang, Qian; Lu, Yan; Proulx, Steven T; Guo, Ruolin; Yao, Zhenqiang; Schwarz, Edward M; Boyce, Brendan F; Xing, Lianping (2007). Increased lymphangiogenesis in joints of mice with inflammatory arthritis. Arthritis research & therapy, 9(6), R118. BioMed Central 10.1186/ar2326