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Xu, Duo; Gao, Yanyun; Yang, Haitang; Spils, Marc; Marti, Thomas M.; Losmanová, Tereza; Su, Min; Wang, Wenxiang; Zhou, Qinghua; Dorn, Patrick; Shu, Yongqian; Peng, Ren-Wang (2024). BAP1 Deficiency Inflames the Tumor Immune Microenvironment and Is a Candidate Biomarker for Immunotherapy Response in Malignant Pleural Mesothelioma. JTO clinical and research reports, 5(5), p. 100672. Elsevier 10.1016/j.jtocrr.2024.100672
Deng, Haibin; Ge, Huixiang; Dubey, Christelle; Losmanova, Tereza; Medova, Michaela; Konstantinidou, Georgia; Mutlu, Seyran Mathilde; Birrer, Fabienne Esther; Brodie, Tess Melinda; Stroka, Deborah; Wang, Wenxiang; Peng, Ren-Wang; Dorn, Patrick; Marti, Thomas Michael (2023). An optimized protocol for the generation and monitoring of conditional orthotopic lung cancer in the KP mouse model using an adeno-associated virus vector compatible with biosafety level 1. Cancer immunology, immunotherapy : CII, 72(12), pp. 4457-4470. Springer 10.1007/s00262-023-03542-z
Orlando, Eleonora; Medo, Matúš; Bensimon, Ariel; Quintin, Aurélie; Riedo, Rahel; Roth, Selina M; Riether, Carsten; Marti, Thomas M; Aebersold, Daniel M; Medová, Michaela; Aebersold, Ruedi; Zimmer, Yitzhak (2023). Correction: An oncogene addiction phosphorylation signature and its derived scores inform tumor responsiveness to targeted therapies. Cellular and molecular life sciences : CMLS, 80(4), p. 85. Springer 10.1007/s00018-023-04725-8
Sengupta, Arunima; Dorn, Aurélien; Jamshidi, Mohammad; Schwob, Magali; Hassan, Widad; De Maddalena, Lea Lara; Hugi, Andreas; Stucki, Andreas O.; Dorn, Patrick; Marti, Thomas M.; Wisser, Oliver; Stucki, Janick D.; Krebs, Tobias; Hobi, Nina; Guenat, Olivier T. (2023). A multiplex inhalation platform to model in situ like aerosol delivery in a breathing lung-on-chip. Frontiers in Pharmacology, 14, p. 1114739. Frontiers 10.3389/fphar.2023.1114739
Yang, Haitang; Gao, Yanyun; Xu, Duo; Xu, Ke; Shun-Qing, Liang; Yang, Zhang; Scherz, Amina; Hall, Sean R R; Forster, Stefan; Berezowska, Sabina; Yao, Feng; Ochsenbein, Adrian F; Marti, Thomas M; Kocher, Gregor J; Schmid, Ralph A; Dorn, Patrick; Peng, Ren-Wang (2023). MEK1 drives oncogenic signaling and interacts with PARP1 for genomic and metabolic homeostasis in malignant pleural mesothelioma. Cell death discovery, 9(1), p. 55. Nature 10.1038/s41420-023-01307-2
Orlando, Eleonora; Medo, Matúš; Bensimon, Ariel; Quintin, Aurélie; Riedo, Rahel; Roth, Selina M; Riether, Carsten; Marti, Thomas M; Aebersold, Daniel M; Medova, Michaela; Aebersold, Ruedi; Zimmer, Yitzhak; quintin, a (2022). An oncogene addiction phosphorylation signature and its derived scores inform tumor responsiveness to targeted therapies. Cellular and molecular life sciences : CMLS, 80(1), p. 6. Springer 10.1007/s00018-022-04634-2
Xu, Duo; Liu, Shengchen; Wu, Xi; Marti, Thomas M; Dorn, Patrick; Schmid, Ralph A; Peng, Ren-Wang; Shu, Yongqian (2022). Dissecting the Immunological Profiles in NSD3-Amplified LUSC through Integrative Multi-Scale Analyses. Cancers, 14(20) MDPI AG 10.3390/cancers14204997
Karatkevich, Darya; Deng, Haibin; Gao, Yanyun; Flint, Emilio; Peng, Ren-Wang; Schmid, Ralph Alexander; Dorn, Patrick; Marti, Thomas Michael (2022). Schedule-Dependent Treatment Increases Chemotherapy Efficacy in Malignant Pleural Mesothelioma. International journal of molecular sciences, 23(19) MDPI 10.3390/ijms231911949
Barut, G Tuba; Halwe, Nico Joel; Taddeo, Adriano; Kelly, Jenna N; Schön, Jacob; Ebert, Nadine; Ulrich, Lorenz; Devisme, Christelle; Steiner, Silvio; Trüeb, Bettina Salome; Hoffmann, Bernd; Berenguer Veiga, Inês; Leborgne, Nathan Georges François; Aguiar Moreira, Etori; Breithaupt, Angele; Wylezich, Claudia; Höper, Dirk; Wernike, Kerstin; Godel, Aurélie; Thomann, Lisa; ... (2022). The spike gene is a major determinant for the SARS-CoV-2 Omicron-BA.1 phenotype. Nature Communications, 13(1), p. 5929. Springer Nature 10.1038/s41467-022-33632-y
Deng, Haibin; Gao, Yanyun; Trappetti, Verdiana; Hertig, Damian; Karatkevich, Darya; Losmanová, Tereza; Urzì, Christian; Ge, Huixiang; Geest, Gerrit Adriaan; Bruggmann, Remy; Djonov, Valentin; Nuoffer, Jean-Marc; Vermathen, Peter; Zamboni, Nicola; Riether, Carsten; Ochsenbein, Adrian; Peng, Ren-Wang; Kocher, Gregor Jan; Schmid, Ralph; Dorn, Patrick; ... (2022). Targeting lactate dehydrogenase B-dependent mitochondrial metabolism affects tumor initiating cells and inhibits tumorigenesis of non-small cell lung cancer by inducing mtDNA damage. Cellular and molecular life sciences, 79(8), p. 445. SP Birkhäuser Verlag Basel 10.1007/s00018-022-04453-5
Guler, Sabina A; Machahua, Carlos; Geiser, Thomas K; Kocher, Gregor; Marti, Thomas M; Tan, Benjamin; Trappetti, Verdiana; Ryerson, Christopher J; Funke-Chambour, Manuela (2022). Dehydroepiandrosterone in fibrotic interstitial lung disease: a translational study. Respiratory research, 23(1), p. 149. BioMed Central 10.1186/s12931-022-02076-9
Sengupta, Arunima; Roldan, Nuria; Kiener, Mirjam; Froment, Laurène; Raggi, Giulia; Imler, Theo; de Maddalena, Lea; Rapet, Aude; May, Tobias; Carius, Patrick; Schneider-Daum, Nicole; Lehr, Claus-Michael; Kruithof-de Julio, Marianna; Geiser, Thomas; Marti, Thomas; Stucki, Janick D.; Hobi, Nina; Guenat, Olivier T (2022). A New Immortalized Human Alveolar Epithelial Cell Model to Study Lung Injury and Toxicity on a Breathing Lung-On-Chip System. Frontiers in toxicology, 4(840606), pp. 1-18. Frontiers Media S.A. 10.3389/ftox.2022.840606
Zeinali, S.; Rechberger, K. F.; Dubey, C.; Gashi, R.; Marti, T.; Dorn, P.; Guenat, O. T. (April 2022). Metastasis-on-chip: 3D human microvasculature network to study extravasation dynamics of lung cancer in vitro. Annals of oncology, 33(S2), S92-S92. Elsevier 10.1016/j.annonc.2022.02.159
Yang, Haitang; Sun, Beibei; Fan, Liwen; Ma, Wenyan; Xu, Ke; Hall, Sean R R; Wang, Zhexin; Schmid, Ralph A; Peng, Ren-Wang; Marti, Thomas M; Gao, Wen; Xu, Jianlin; Yang, Weiwei; Yao, Feng (2022). Multi-scale integrative analyses identify THBS2+ cancer-associated fibroblasts as a key orchestrator promoting aggressiveness in early-stage lung adenocarcinoma. Theranostics, 12(7), pp. 3104-3130. Ivyspring International 10.7150/thno.69590
Yang, Zhang; Shun-Qing, Liang; Zhao, Liang; Yang, Haitang; Marti, Thomas M; Hegedüs, Balazs; Gao, Yanyun; Zheng, Bin; Chen, Chun; Wang, Wenxiang; Dorn, Patrick; Kocher, Gregor J; Schmid, Ralph A; Peng, Ren-Wang (2022). Metabolic synthetic lethality by targeting NOP56 and mTOR in KRAS-mutant lung cancer. Journal of experimental & clinical cancer research, 41(1), p. 25. BioMed Central 10.1186/s13046-022-02240-5
Lipp, Jesse J; Wang, Limei; Yang, Haitang; Yao, Feng; Harrer, Nathalie; Müller, Stefan; Berezowska, Sabina; Dorn, Patrick; Marti, Thomas M; Schmid, Ralph A; Hegedüs, Belazs; Souabni, Abdallah; Carotta, Sebastian; Pearson, Mark A; Sommergruber, Wolfgang; Kocher, Gregor J; Hall, Sean R R (2022). Functional and molecular characterization of PD1+ tumor-infiltrating lymphocytes from lung cancer patients. Oncoimmunology, 11(1), p. 2019466. Taylor & Francis 10.1080/2162402X.2021.2019466
Barut, Tuba; Halwe, Nico Joel; Taddeo, Adriano; Kelly, Jenna N.; Schön, Jacob; Ebert, Nadine; Ulrich, Lorenz; Devisme, Christelle; Steiner, Silvio; Trüeb, Bettina Salome; Hoffmann, Bernd; Berenguer Veiga, Inês; Leborgne, Nathan Georges François; Aguiar Moreira, Etori; Breithaupt, Angele; Wylezich, Claudia; Höper, Dirk; Wernike, Kerstin; Godel, Aurélie; Thomann, Lisa; ... (2022). The spike gene is a major determinant for the SARS-CoV-2 Omicron-BA. 1 phenotype (bioRxiv). Cold Spring Harbor Laboratory
Ning, Wenjuan; Marti, Thomas M; Dorn, Patrick; Peng, Ren-Wang (2022). Non-genetic adaptive resistance to KRASG12C inhibition: EMT is not the only culprit. Frontiers in oncology, 12, p. 1004669. Frontiers Research Foundation 10.3389/fonc.2022.1004669
Yang, Haitang; Berezowska, Sabina; Dorn, Patrick; Zens, Philipp; Chen, Peiru; Peng, Ren-Wang; Marti, Thomas M; Kocher, Gregor J; Schmid, Ralph A; Hall, Sean R R (2022). Tumor-infiltrating lymphocytes are functionally inactivated by CD90+ stromal cells and reactivated by combined Ibrutinib and Rapamycin in human pleural mesothelioma. Theranostics, 12(1), pp. 167-185. Ivyspring International 10.7150/thno.61209
Wang, Limei; Yang, Haitang; Dorn, Patrick; Berezowska, Sabina; Blank, Fabian; Wotzkow, Carlos; Marti, Thomas M; Peng, Ren-Wang; Harrer, Nathalie; Sommergruber, Wolfgang; Kocher, Gregor J; Schmid, Ralph A; Hall, Sean R R (2021). Peritumoral CD90+CD73+ cells possess immunosuppressive features in human non-small cell lung cancer. EBioMedicine, 73, p. 103664. Elsevier 10.1016/j.ebiom.2021.103664
Yang, Zhang; Liang, Shun-Qing; Saliakoura, Maria; Yang, Haitang; Vassella, Erik; Konstantinidou, Georgia; Tschan, Mario; Hegedüs, Balazs; Zhao, Liang; Gao, Yanyun; Xu, Duo; Deng, Haibin; Marti, Thomas M; Kocher, Gregor J; Wang, Wenxiang; Schmid, Ralph A; Peng, Ren-Wang (2021). Synergistic effects of FGFR1 and PLK1 inhibitors target a metabolic liability in KRAS-mutant cancer. EMBO molecular medicine, 13(9), e13193. EMBO Press 10.15252/emmm.202013193
Brügger, Melanie; Démoulins, Thomas; Barut, G. Tuba; Zumkehr, Beatrice; Oliveira Esteves, Blandina I.; Mehinagic, Kemal; Haas, Quentin; Schögler, Aline; Rameix-Welti, Marie-Anne; Eléouët, Jean-François; Moehrlen, Ueli; Marti, Thomas M.; Schmid, Ralph A.; Summerfield, Artur; Posthaus, Horst; Ruggli, Nicolas; Hall, Sean R. R.; Alves, Marco P. (2021). Pulmonary mesenchymal stem cells are engaged in distinct steps of host response to respiratory syncytial virus infection. PLoS pathogens, 17(7), e1009789. Public Library of Science 10.1371/journal.ppat.1009789
Yang, Zhang; Liang, Shun-Qing; Yang, Haitang; Xu, Duo; Bruggmann, Rémy; Gao, Yanyun; Deng, Haibin; Berezowska, Sabina; Hall, Sean R R; Marti, Thomas M; Kocher, Gregor J; Zhou, Qinghua; Schmid, Ralph A; Peng, Ren-Wang (2021). CRISPR-Mediated Kinome Editing Prioritizes a Synergistic Combination Therapy for FGFR1-Amplified Lung Cancer. Cancer research, 81(11), pp. 3121-3133. American Association for Cancer Research AACR 10.1158/0008-5472.CAN-20-2276
Gao, Yanyun; Zens, Philipp; Su, Min; Gemperli, Camila Anna; Yang, Haitang; Deng, Haibin; Yang, Zhang; Xu, Duo; Hall, Sean R R; Berezowska, Sabina; Dorn, Patrick; Peng, Ren-Wang; Schmid, Ralph Alexander; Wang, Wenxiang; Marti, Thomas Michael (2021). Chemotherapy-induced CDA expression renders resistant non-small cell lung cancer cells sensitive to 5'-deoxy-5-fluorocytidine (5'-DFCR). Journal of experimental & clinical cancer research, 40(1), pp. 1-22. BioMed Central 10.1186/s13046-021-01938-2
Xu, Duo; Liang, Shun-Qing; Yang, Zhang; Yang, Haitang; Bruggmann, Rémy; Oberhaensli, Simone; Berezowska, Sabina; Marti, Thomas M; Hall, Sean R R; Dorn, Patrick; Kocher, Gregor J; Schmid, Ralph A; Peng, Ren-Wang (2021). Malignant pleural mesothelioma co-opts BCL-XL and autophagy to escape apoptosis. Cell death & disease, 12(4), p. 406. Nature Publishing Group 10.1038/s41419-021-03668-x
Wang, Limei; Dorn, Patrick; Simillion, Cedric; Froment, Laurène; Berezowska, Sabina Anna; Tschanz, Stefan A.; Haenni, Beat; Blank, Fabian; Wotzkow, Carlos; Peng, Ren-Wang; Marti, Thomas; Bode, Peter Karl; Moehrlen, Ueli; Schmid, Ralph; Hall, Sean (2020). EpCAM+CD73+ mark epithelial progenitor cells in postnatal human lung and is associated with pathogenesis of pulmonary disease including lung adenocarcinoma. American journal of physiology - lung cellular and molecular physiology, 319(5), L794-L809. American Physiological Society 10.1152/ajplung.00279.2019
