Handschin, Alexander E; Egermann, Marcus; Trentz, Otmar; Wanner, Guido A; Kock, Hans-Jürgen; Zünd, Gregor; Trentz, Omana Anna (2006). Cbfa-1 (Runx-2) and osteocalcin expression by human osteoblasts in heparin osteoporosis in vitro. Clinical and applied thrombosis, hemostasis, 12(4), pp. 465-72. Thousand Oaks, Calif.: Sage 10.1177/1076029606293433
Full text not available from this repository. (Request a copy)Heparin may cause adverse effects on bone formation following long-term application. The exact pathomechanism is unclear, but in vitro data suggest an impaired osteoblast function. The transcription axis of Cbfa-1 (Runx-2) and osteocalcin is crucial in maintaining an equilibrium of bone formation and resorption in vivo. We used a human osteoblast cell culture model to further investigate the effect of heparin (low-molecular-weight heparin, dalteparin) on the expression of these two regulators of osteoblast differentiation. At high doses, dalteparin caused a significant inhibition of both osteocalcin and Cbfa-1 expression in vitro. Our data support the hypothesis of a direct inhibition of osteoblast function underlying heparin osteoporosis.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Orthopaedic, Plastic and Hand Surgery (DOPH) > Clinic of Plastic and Hand Surgery > Plastic, Reconstructive and Aesthetic Surgery |
UniBE Contributor: |
Handschin, Alexander |
ISSN: |
1076-0296 |
ISBN: |
17000892 |
Publisher: |
Sage |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:51 |
Last Modified: |
05 Dec 2022 14:16 |
Publisher DOI: |
10.1177/1076029606293433 |
PubMed ID: |
17000892 |
Web of Science ID: |
000240762400009 |
URI: |
https://boris.unibe.ch/id/eprint/21738 (FactScience: 13453) |
Actions (login required)
 |
Edit item |