Cbfa-1 (Runx-2) and osteocalcin expression by human osteoblasts in heparin osteoporosis in vitro

Handschin, Alexander E; Egermann, Marcus; Trentz, Otmar; Wanner, Guido A; Kock, Hans-Jürgen; Zünd, Gregor; Trentz, Omana Anna (2006). Cbfa-1 (Runx-2) and osteocalcin expression by human osteoblasts in heparin osteoporosis in vitro. Clinical and applied thrombosis, hemostasis, 12(4), pp. 465-72. Thousand Oaks, Calif.: Sage 10.1177/1076029606293433

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Heparin may cause adverse effects on bone formation following long-term application. The exact pathomechanism is unclear, but in vitro data suggest an impaired osteoblast function. The transcription axis of Cbfa-1 (Runx-2) and osteocalcin is crucial in maintaining an equilibrium of bone formation and resorption in vivo. We used a human osteoblast cell culture model to further investigate the effect of heparin (low-molecular-weight heparin, dalteparin) on the expression of these two regulators of osteoblast differentiation. At high doses, dalteparin caused a significant inhibition of both osteocalcin and Cbfa-1 expression in vitro. Our data support the hypothesis of a direct inhibition of osteoblast function underlying heparin osteoporosis.

Item Type:	Journal Article (Original Article)
Division/Institute:	04 Faculty of Medicine > Department of Orthopaedic, Plastic and Hand Surgery (DOPH) > Clinic of Plastic and Hand Surgery > Plastic, Reconstructive and Aesthetic Surgery
UniBE Contributor:	Handschin, Alexander
ISSN:	1076-0296
ISBN:	17000892
Publisher:	Sage
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:51
Last Modified:	05 Dec 2022 14:16
Publisher DOI:	10.1177/1076029606293433
PubMed ID:	17000892
Web of Science ID:	000240762400009
URI:	https://boris.unibe.ch/id/eprint/21738 (FactScience: 13453)