Novel magnetic resonance technique for functional imaging of cystic fibrosis lung disease

Nyilas, Sylvia Meryl; Bauman, G.; Sommer, G.; Stranzinger, Enno; Pusterla, O.; Frey, U.; Korten, Insa Christina Severine; Singer, Florian; Casaulta Aebischer, Carmen; Bieri, O.; Latzin, Philipp (June 2017). Novel magnetic resonance technique for functional imaging of cystic fibrosis lung disease (Unpublished). In: SCR Schweizer Radiologie Kongress. Bern.

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Purpose: Cystic fibrosis (CF) is characterized by chronic respiratory infections and functional impairment of the lung. Lung function tests such as nitrogen multiple breath washout (N2-MBW), are sensitive in detecting ventilation inhomogeneity, but cannot determine its exact origin. Novel magnetic resonance imaging (MRI) methods such as matrix pencil decomposition MRI can visualize functional changes in the lung without the administration of contrast agents and the need for breathing maneuvers. Objectives: To examine the correlation between novel functional MRI and lung function tests in patients with CF. Methods and Materials: Methods: Forty patients with CF (mean age 11.7 years, range 6–18) underwent MRI and lung function tests on the same day. Functional MRI provided semi-quantitative measures of the perfusion (RQ) and ventilation (RFV) impairment as percentages of the affected lung volume. Morphological MRI was evaluated using a CF-specific score. N2-MBW provided information about global (lung clearance index, LCI) ventilation inhomogeneity. Results: Results: MRI detected functional impairment in all patients with CF: RFV ranged from 19% to 38% and RQ ranged from 16% to 35%. RFV and RQ were strongly correlated with LCI (r=0.76, p<0.001; r=0.85, p<0.001, respectively), as well as total morphology scores and sub-scores. Conclusion: Conclusions: Non-invasive functional MRI is a promising method to detect and visualize perfusion and ventilation impairment in CF without the need of contrast agents or breath holding maneuvers.

Item Type:

Conference or Workshop Item (Poster)

Division/Institute:

04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Forschungsgruppe Pneumologie (Pädiatrie)
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Paediatric Pneumology

UniBE Contributor:

Nyilas, Sylvia Meryl; Stranzinger, Enno; Korten, Insa Christina Severine; Singer, Florian; Casaulta Aebischer, Carmen and Latzin, Philipp

Subjects:

600 Technology > 610 Medicine & health

Language:

English

Submitter:

Nicole Rösch

Date Deposited:

23 Oct 2017 07:33

Last Modified:

09 May 2018 14:12

BORIS DOI:

10.7892/boris.101492

URI:

https://boris.unibe.ch/id/eprint/101492

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