Nyilas, Sylvia Meryl; Bauman, G.; Sommer, G.; Stranzinger, Enno; Pusterla, O.; Frey, U.; Korten, Insa Christina Severine; Singer, Florian; Casaulta Aebischer, Carmen; Bieri, O.; Latzin, Philipp (June 2017). Novel magnetic resonance technique for functional imaging of cystic fibrosis lung disease (Unpublished). In: SCR Schweizer Radiologie Kongress. Bern.
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Purpose: Cystic fibrosis (CF) is characterized by chronic respiratory infections
and functional impairment of the lung. Lung function tests such as
nitrogen multiple breath washout (N2-MBW), are sensitive in detecting
ventilation inhomogeneity, but cannot determine its exact origin. Novel
magnetic resonance imaging (MRI) methods such as matrix pencil decomposition
MRI can visualize functional changes in the lung without the administration
of contrast agents and the need for breathing maneuvers.
Objectives: To examine the correlation between novel functional MRI and
lung function tests in patients with CF.
Methods and Materials: Methods: Forty patients with CF (mean age 11.7
years, range 6–18) underwent MRI and lung function tests on the same day.
Functional MRI provided semi-quantitative measures of the perfusion (RQ)
and ventilation (RFV) impairment as percentages of the affected lung volume.
Morphological MRI was evaluated using a CF-specific score. N2-MBW
provided information about global (lung clearance index, LCI) ventilation
inhomogeneity.
Results: Results: MRI detected functional impairment in all patients with
CF: RFV ranged from 19% to 38% and RQ ranged from 16% to 35%. RFV and
RQ were strongly correlated with LCI (r=0.76, p<0.001; r=0.85, p<0.001, respectively),
as well as total morphology scores and sub-scores.
Conclusion: Conclusions: Non-invasive functional MRI is a promising method
to detect and visualize perfusion and ventilation impairment in CF without
the need of contrast agents or breath holding maneuvers.
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