Limbic interference during social action planning in schizophrenia

Stegmayer, Katharina; Bohlhalter, Stephan; Vanbellingen, Tim; Federspiel, Andrea; Wiest, Roland; Müri, René Martin; Strik, Werner; Walther, Sebastian (2018). Limbic interference during social action planning in schizophrenia. Schizophrenia bulletin, 44(2), pp. 359-368. Oxford University Press 10.1093/schbul/sbx059

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Schizophrenia is characterized by social interaction deficits contributing to poor functional outcome. Hand gesture use is particularly impaired, linked to frontal lobe dysfunction and frontal grey matter deficits. The functional neural correlates of impaired gesturing are currently unclear. We therefore investigated aberrant brain activity during impaired gesturing in schizophrenia. We included 22 patients with schizophrenia and 25 healthy control participants matched for age, gender, and education level. We obtained functional magnetic resonance imaging data using an event-related paradigm to assess brain activation during gesture planning and execution. Group differences in whole brain effects were calculated using factorial designs. Gesture ratings were performed by a single rater, blind to diagnoses and clinical presentation. During gesture planning and execution both groups activated brain areas of the praxis network. However, patients had reduced dorsolateral prefrontal cortex (DLPFC) and increased inferior parietal lobe (IPL) activity. Performance accuracy was associated with IPL activity in patients. Furthermore, patients activated temporal poles, amygdala and hippocampus during gesture planning, which was associated with delusion severity. Finally, patients demonstrated increased dorsomedial prefrontal cortex activity during planning of novel gestures. We demonstrate less prefrontal, but more IPL and limbic activity during gesturing in schizophrenia. IPL activity was associated with performance accuracy, whereas limbic activity was linked to delusion severity. These findings may reflect impaired social action planning and a limbic interference with gestures in schizophrenia contributing to poor gesture performance and consequently poor social functioning in schizophrenia.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy > Translational Research Center
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Psychiatry and Psychotherapy
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic and Interventional Neuroradiology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DCR Unit Sahli Building > Forschungsgruppe Neurologie
10 Strategic Research Centers > ARTORG Center for Biomedical Engineering Research > ARTORG Center - Gerontechnology and Rehabilitation

UniBE Contributor:

Stegmayer, Katharina; Bohlhalter, Stephan; Vanbellingen, Tim; Federspiel, Andrea; Wiest, Roland; Müri, René Martin; Strik, Werner and Walther, Sebastian

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0586-7614

Publisher:

Oxford University Press

Language:

English

Submitter:

Sebastian Walther

Date Deposited:

08 Aug 2017 09:36

Last Modified:

24 Jan 2019 14:33

Publisher DOI:

10.1093/schbul/sbx059

PubMed ID:

28575506

Uncontrolled Keywords:

amygdala; delusions, fMRI, gesture performance, nonverbal communication, social cognition

BORIS DOI:

10.7892/boris.101564

URI:

https://boris.unibe.ch/id/eprint/101564

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