The relapse risk of AML patients undergoing autologous transplantation correlates with the stem cell mobilizing potential

von Grünigen, Isabelle; Raschle, Joëlle; Rüsges-Wolter, Ilka; Taleghani, Behrouz Mansouri; Mueller, Beatrice U; Pabst, Thomas (2012). The relapse risk of AML patients undergoing autologous transplantation correlates with the stem cell mobilizing potential. Leukemia research, 36(11), pp. 1325-9. Amsterdam: Elsevier 10.1016/j.leukres.2012.05.027

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Autologous stem cell transplantation (ASCT) is widely used to consolidate first remission in AML. We determined the significance of circulating CD34+ cells at the day of blood stem cell collection in 78 AML patients. Patients mobilizing more than 60,000 CD34+ cells/ml had shorter overall survival (OS; P=0.0274), shorter time to progression (TTP; P=0.0014), and a higher relapse rate (P=0.0177). High levels of CD34+ cells were an independent marker for shorter OS and TTP in a multivariate analysis. These data suggest that ASCT is associated with unfavorable outcome in AML patients with high levels of mobilized peripheral CD34+ cells.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Haematology and Central Haematological Laboratory
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology

UniBE Contributor:

Mansouri Taleghani, Behrouz and Pabst, Thomas

ISSN:

0145-2126

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:28

Last Modified:

06 Dec 2013 13:32

Publisher DOI:

10.1016/j.leukres.2012.05.027

PubMed ID:

22727508

Web of Science ID:

000309262200002

URI:

https://boris.unibe.ch/id/eprint/10379 (FactScience: 216251)

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