von Grünigen, Isabelle; Raschle, Joëlle; Rüsges-Wolter, Ilka; Taleghani, Behrouz Mansouri; Mueller, Beatrice U; Pabst, Thomas (2012). The relapse risk of AML patients undergoing autologous transplantation correlates with the stem cell mobilizing potential. Leukemia research, 36(11), pp. 1325-9. Amsterdam: Elsevier 10.1016/j.leukres.2012.05.027
Full text not available from this repository. (Request a copy)Autologous stem cell transplantation (ASCT) is widely used to consolidate first remission in AML. We determined the significance of circulating CD34+ cells at the day of blood stem cell collection in 78 AML patients. Patients mobilizing more than 60,000 CD34+ cells/ml had shorter overall survival (OS; P=0.0274), shorter time to progression (TTP; P=0.0014), and a higher relapse rate (P=0.0177). High levels of CD34+ cells were an independent marker for shorter OS and TTP in a multivariate analysis. These data suggest that ASCT is associated with unfavorable outcome in AML patients with high levels of mobilized peripheral CD34+ cells.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Haematology and Central Haematological Laboratory 04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology |
UniBE Contributor: |
Mansouri Taleghani, Behrouz, Pabst, Thomas Niklaus |
ISSN: |
0145-2126 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:28 |
Last Modified: |
02 Mar 2023 23:21 |
Publisher DOI: |
10.1016/j.leukres.2012.05.027 |
PubMed ID: |
22727508 |
Web of Science ID: |
000309262200002 |
URI: |
https://boris.unibe.ch/id/eprint/10379 (FactScience: 216251) |
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