Parental occupational exposure to benzene and the risk of childhood cancer: A census-based cohort study.

Spycher, Ben Daniel; Lupatsch, Judith Eva; Huss, Anke; Rischewski, Johannes; Schindera, Christina; Spörri, Adrian; Vermeulen, Roel; Kuehni, Claudia Elisabeth; Swiss Paediatric Oncology, Group; Swiss National Cohort Study, Group (2017). Parental occupational exposure to benzene and the risk of childhood cancer: A census-based cohort study. Environment International, 108, pp. 84-91. Elsevier 10.1016/j.envint.2017.07.022

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BACKGROUND Previous studies on occupational exposures in parents and cancer risks in their children support a link between solvents and paints with childhood leukaemia. Few studies have focused specifically on benzene. OBJECTIVES To examine whether parental occupational exposure to benzene is associated with an increased cancer risk in a census-based cohort of children. METHODS From a census-based cohort study in Switzerland, we included children aged <16years at national censuses (1990, 2000). We retrieved parental occupations reported at census and assessed exposure to benzene using a job exposure matrix. We identified incident cancer cases through record linkage with the Swiss Childhood Cancer Registry. We fitted Cox proportional-hazards models to assess associations between exposures and the following outcomes: any cancer, leukaemia, acute lymphoid leukaemia (ALL), acute myeloid leukaemia (AML), lymphoma, non-Hodgkin lymphoma, central nervous system (CNS) tumours, and glioma. We adjusted models for a range of socio-economic, perinatal and environmental factors. RESULTS Analyses of maternal (paternal) exposure were based on 9.0 (13.2)millionperson years at risk and included 1004 (1520) cases of cancer, of which 285 (438) had leukaemia, 186 (281) lymphoma, 227 (339) a CNS tumour. Maternal exposure was associated with an increased risk of childhood leukaemia (hazard ratio 1.73, 95% CI 1.12-2.67) and ALL (1.88, 1.16-3.04). We found little evidence of an association for other outcomes or for paternal exposure. Adjusting for potential confounders did not materially affect the results. CONCLUSIONS This nationwide cohort study suggests an increased risk of leukaemia among children whose mothers were exposed to benzene at work.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)

UniBE Contributor:

Spycher, Ben; Lupatsch, Judith Eva; Schindera, Christina; Spörri, Adrian and Kühni, Claudia

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

0160-4120

Publisher:

Elsevier

Language:

English

Submitter:

Doris Kopp Heim

Date Deposited:

24 Aug 2017 15:27

Last Modified:

28 Jul 2018 02:30

Publisher DOI:

10.1016/j.envint.2017.07.022

PubMed ID:

28802171

Uncontrolled Keywords:

Air pollution Aromatic hydrocarbons Job exposure matrix Leukaemia Lymphoma Occupational hygiene Paints Solvents Tumours of the central nervous system Workplace

BORIS DOI:

10.7892/boris.105124

URI:

https://boris.unibe.ch/id/eprint/105124

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