Regional Differences in Cerebral Glucose Metabolism After Cardiac Arrest and Resuscitation in Rats Using [(18)F]FDG Positron Emission Tomography and Autoradiography.

Putzu, Alessandro; Valtorta, Silvia; Di Grigoli, Giuseppe; Hänggi, Matthias; Belloli, Sara; Malgaroli, Antonio; Gemma, Marco; Landoni, Giovanni; Beretta, Luigi; Moresco, Rosa Maria (2018). Regional Differences in Cerebral Glucose Metabolism After Cardiac Arrest and Resuscitation in Rats Using [(18)F]FDG Positron Emission Tomography and Autoradiography. Neurocritical care, 28(3), pp. 370-378. Springer 10.1007/s12028-017-0445-0

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BACKGROUND Cardiac arrest is an important cause of morbidity and mortality. Brain injury severity and prognosis of cardiac arrest patients are related to the cerebral areas affected. To this aim, we evaluated the variability and the distribution of brain glucose metabolism after cardiac arrest and resuscitation in an adult rat model. METHODS Ten rats underwent 8-min cardiac arrest, induced with a mixture of potassium and esmolol, and resuscitation, performed with chest compressions and epinephrine. Eight sham animals received anesthesia and experimental procedures identical to the ischemic group except cardiac arrest induction. Brain metabolism was assessed using [(18)F]FDG autoradiography and small animal-dedicated positron emission tomography. RESULTS The absolute glucose metabolism measured with [(18)F]FDG autoradiography 2 h after cardiac arrest and resuscitation was lower in the frontal, parietal, occipital, and temporal cortices of cardiac arrest animals, showing, respectively, a 36% (p = 0.006), 32% (p = 0.016), 36% (p = 0.009), and 32% (p = 0.013) decrease compared to sham group. Striatum, hippocampus, thalamus, brainstem, and cerebellum showed no significant changes. Relative regional metabolism indicated a redistribution of metabolism from cortical area to brainstem and cerebellum. CONCLUSIONS Our data suggest that cerebral regions have different susceptibility to moderate global ischemia in terms of glucose metabolism. The neocortex showed a higher sensibility to hypoxia-ischemia than other regions. Other subcortical regions, in particular brainstem and cerebellum, showed no significant change compared to non-ischemic rats.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic of Intensive Care

UniBE Contributor:

Hänggi, Matthias

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1541-6933

Publisher:

Springer

Language:

English

Submitter:

Mirella Aeberhard

Date Deposited:

08 Nov 2017 09:23

Last Modified:

29 Jun 2018 01:30

Publisher DOI:

10.1007/s12028-017-0445-0

PubMed ID:

28875429

Uncontrolled Keywords:

Animal model Brain injury Brain ischemia Brain metabolism Cardiac arrest Resuscitation

BORIS DOI:

10.7892/boris.105338

URI:

https://boris.unibe.ch/id/eprint/105338

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