Recurrent Inflammatory Flares in HIV-Infected Patients: Consider Castleman Disease!

Jegerlehner, Sabrina; Rauch, Andri; Novak, Urban (2017). Recurrent Inflammatory Flares in HIV-Infected Patients: Consider Castleman Disease! Journal of investigative medicine high impact case reports, 5(3), p. 2324709617725094. Sage 10.1177/2324709617725094

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Background. Transient inflammatory flares are common in clinical care of human immunodeficiency virus (HIV)-infected patients. In-depth investigations are not performed routinely because patients often recover without therapeutic interventions, and therefore, the etiologies of these inflammatory flares frequently remain unknown. Case. We report a case of an HIV-infected patient with recurrent inflammatory flares during several years in whom diagnostic workup with a lymph node biopsy finally revealed multicentric Castleman disease (MCD). The patient was treated with etoposide and rituximab until November 2013 and achieved ongoing complete clinical remission. Conclusion. Recent effective therapeutic regimens offer an opportunity to prevent serious complications of MCD including its malignant transformation, provided that the diagnosis is established early enough. Therefore, clinicians should consider MCD in the differential diagnosis of self-limiting inflammatory flares, especially in HIV-infected patients.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of General Internal Medicine (DAIM) > Clinic of General Internal Medicine
04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > University Emergency Center
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology

UniBE Contributor:

Jegerlehner, Sabrina; Rauch, Andri and Novak, Urban

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2324-7096

Publisher:

Sage

Language:

English

Submitter:

Annelies Luginbühl

Date Deposited:

22 Nov 2017 10:02

Last Modified:

29 May 2018 07:09

Publisher DOI:

10.1177/2324709617725094

PubMed ID:

28959691

Uncontrolled Keywords:

Castleman disease HIV infection etoposide inflammatory flares rituximab treatment

BORIS DOI:

10.7892/boris.106094

URI:

https://boris.unibe.ch/id/eprint/106094

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