Impact of human papillomavirus on outcome in patients with oropharyngeal cancer treated with primary surgery.

Broglie, Martina A; Stoeckli, Sandro J; Sauter, Rafael; Pasche, Philippe; Reinhard, Antoine; de Leval, Laurence; Huber, Gerhard F; Pezier, Thomas F; Soltermann, Alex; Giger, Roland; Arnold, Andreas; Dettmer, Matthias; Arnoux, Andre; Müller, Martin; Spreitzer, Stefan; Lang, Florian; Lutchmaya, Mathieu; Stauffer, Edouard; Espeli, Vittoria; Martucci, Francesco; ... (2017). Impact of human papillomavirus on outcome in patients with oropharyngeal cancer treated with primary surgery. Head & neck - journal for the sciences and specialties of the head and neck, 39(10), pp. 2004-2015. J. Wiley 10.1002/hed.24865

[img] Text
Broglie_et_al-2017-Head_&_Neck.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (752kB) | Request a copy

BACKGROUND Knowledge about prognostic factors in surgically treated patients with oropharyngeal squamous cell carcinoma (SCC) is limited. The purpose of this study was to identify influential factors on survival in a large cohort of patients with surgically treated oropharyngeal SCC. METHODS Retrospective analysis of survival estimates in patients with surgically treated oropharyngeal SCC using tumoral positivity for human papillomavirus (HPV) and risk-of-death categories according to a study from 2010 as stratification factors. RESULTS The 5-year overall survival (OS) and disease-specific survival (DSS) rates after surgery alone were higher in HPV-associated oropharyngeal SCC (OS 80% vs 62%; P = .01; DSS 92% vs 76%; P = .03). Patients in the low-risk category had higher survival rates (OS 91%; DSS 99%) than patients in the intermediate-risk group (OS 63%; DSS 83%), and high-risk group (OS 61%; DSS 75%). CONCLUSION Nonsmokers with HPV-positive oropharyngeal SCC have a better prognosis than smokers with HPV-positive oropharyngeal SCC and also than patients with HPV-negative tumors when treated by surgery alone.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ear, Nose and Throat Disorders (ENT)
04 Faculty of Medicine > Service Sector > Institute of Pathology > Clinical Pathology
04 Faculty of Medicine > Service Sector > Institute of Pathology > Tumour Pathology

UniBE Contributor:

Giger, Roland; Arnold, Andreas Michael and Dettmer, Matthias

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1043-3074

Publisher:

J. Wiley

Language:

English

Submitter:

Matthias Dettmer

Date Deposited:

17 Nov 2017 15:51

Last Modified:

17 Nov 2017 15:51

Publisher DOI:

10.1002/hed.24865

PubMed ID:

28691255

Uncontrolled Keywords:

human papillomavirus oropharynx squamous cell cancer surgery survival

BORIS DOI:

10.7892/boris.107141

URI:

https://boris.unibe.ch/id/eprint/107141

Actions (login required)

Edit item Edit item
Provide Feedback