Directional local field potentials: A tool to optimize deep brain stimulation.

Tinkhauser, Gerd; Pogosyan, Alek; Debove, Ines; Nowacki, Andreas; Shah, Syed Ahmar; Seidel, Kathleen; Tan, Huiling; Brittain, John-Stuart; Petermann, Katrin; di Biase, Lazzaro; Oertel, Markus Florian; Pollo, Claudio; Brown, Peter; Schüpbach, Michael (2018). Directional local field potentials: A tool to optimize deep brain stimulation. Movement disorders, 33(1), pp. 159-164. Wiley-Blackwell 10.1002/mds.27215

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BACKGROUND Although recently introduced directional DBS leads provide control of the stimulation field, programing is time-consuming. OBJECTIVES Here, we validate local field potentials recorded from directional contacts as a predictor of the most efficient contacts for stimulation in patients with PD. METHODS Intraoperative local field potentials were recorded from directional contacts in the STN of 12 patients and beta activity compared with the results of the clinical contact review performed after 4 to 7 months. RESULTS Normalized beta activity was positively correlated with the contact's clinical efficacy. The two contacts with the highest beta activity included the most efficient stimulation contact in up to 92% and that with the widest therapeutic window in 74% of cases. CONCLUSION Local field potentials predict the most efficient stimulation contacts and may provide a useful tool to expedite the selection of the optimal contact for directional DBS. © 2017 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery

UniBE Contributor:

Tinkhauser, Gerd; Debove, Ines; Nowacki, Andreas; Seidel, Kathleen; Petermann, Katrin; Oertel, Markus Florian; Pollo, Claudio and Schüpbach, Michael

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0885-3185

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Stefanie Hetzenecker

Date Deposited:

13 Dec 2017 13:31

Last Modified:

26 Oct 2019 02:31

Publisher DOI:

10.1002/mds.27215

PubMed ID:

29150884

Uncontrolled Keywords:

DBS programming Parkinson's disease deep brain stimulation directional leads local field potentials

BORIS DOI:

10.7892/boris.107258

URI:

https://boris.unibe.ch/id/eprint/107258

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