Tinkhauser, Gerd; Pogosyan, Alek; Debove, Ines; Nowacki, Andreas; Shah, Syed Ahmar; Seidel, Kathleen; Tan, Huiling; Brittain, John-Stuart; Petermann, Katrin; di Biase, Lazzaro; Oertel, Markus Florian; Pollo, Claudio; Brown, Peter; Schüpbach, Michael (2018). Directional local field potentials: A tool to optimize deep brain stimulation. Movement disorders, 33(1), pp. 159-164. Wiley-Blackwell 10.1002/mds.27215
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BACKGROUND
Although recently introduced directional DBS leads provide control of the stimulation field, programing is time-consuming.
OBJECTIVES
Here, we validate local field potentials recorded from directional contacts as a predictor of the most efficient contacts for stimulation in patients with PD.
METHODS
Intraoperative local field potentials were recorded from directional contacts in the STN of 12 patients and beta activity compared with the results of the clinical contact review performed after 4 to 7 months.
RESULTS
Normalized beta activity was positively correlated with the contact's clinical efficacy. The two contacts with the highest beta activity included the most efficient stimulation contact in up to 92% and that with the widest therapeutic window in 74% of cases.
CONCLUSION
Local field potentials predict the most efficient stimulation contacts and may provide a useful tool to expedite the selection of the optimal contact for directional DBS. © 2017 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology 04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery |
UniBE Contributor: |
Tinkhauser, Gerd, Debove, Ines, Nowacki, Andreas, Seidel, Kathleen, Petermann, Katrin, Oertel, Markus Florian, Pollo, Claudio, Schüpbach, Michael |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0885-3185 |
Publisher: |
Wiley-Blackwell |
Language: |
English |
Submitter: |
Stefanie Hetzenecker |
Date Deposited: |
13 Dec 2017 13:31 |
Last Modified: |
05 Dec 2022 15:08 |
Publisher DOI: |
10.1002/mds.27215 |
PubMed ID: |
29150884 |
Uncontrolled Keywords: |
DBS programming Parkinson's disease deep brain stimulation directional leads local field potentials |
BORIS DOI: |
10.7892/boris.107258 |
URI: |
https://boris.unibe.ch/id/eprint/107258 |
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