The time window for successful right-hemispheric language reorganization in children.

Lidzba, Karen; Küpper, Hanna; Kluger, Gerhard; Staudt, Martin (2017). The time window for successful right-hemispheric language reorganization in children. European journal of paediatric neurology, 21(5), pp. 715-721. Elsevier 10.1016/j.ejpn.2017.06.001

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AIM To identify, in a retrospective, observational study, the time window during which successful right-hemispheric language reorganization is possible after left-hemispheric brain damage. METHOD 25 patients (10 females; age 6-41 years; ≥12 months after insult; age at insult 0;3-15;11 years) with acute, language-relevant left-hemispheric insults acquired during childhood and adolescence completed questionnaires for self-assessment of language problems. 12 patients of those reporting no (n = 8) or only moderate (n = 4) language problems participated in language fMRI. RESULTS Language outcome of lesions occurring before 5 years of age (n = 7) was always favorable, and language was right-lateralized (2 patients: age at lesion < 2 years) or bilateral (3 patients: age at lesion 2-5 years). Following lesions occurring after 5 years of age, language outcome was often unfavorable (11/18 patients: moderate or severe problems), and of the 7 patients without problems, none showed right-hemispheric reorganization (fMRI available in 4). INTERPRETATION The combination of normal language outcome and right-hemispheric language reorganization after a left-hemispheric lesion sustained after the neonatal period is extremely rare. Functionally sufficient right-hemispheric language was documented in only two patients with lesions acquired before two years of age.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Neuropaediatrics

UniBE Contributor:

Lidzba, Karen

ISSN:

1090-3798

Publisher:

Elsevier

Language:

English

Submitter:

Karen Lidzba

Date Deposited:

20 Feb 2018 08:31

Last Modified:

20 Feb 2018 08:31

Publisher DOI:

10.1016/j.ejpn.2017.06.001

PubMed ID:

28648758

Uncontrolled Keywords:

Aphasia Brain plasticity Childhood stroke

BORIS DOI:

10.7892/boris.107438

URI:

https://boris.unibe.ch/id/eprint/107438

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