Trends in hepatitis C-related mortality in Switzerland

Keiser, O; Giudici, F; Müllhaupt, B; Junker, C; Dufour, J-F; Moradpour, D; Bruggmann, P; Terziroli, B; Semela, D; Brezzi, M; Bertisch, B; Estill, J; Negro, F; Spoerri, A (2018). Trends in hepatitis C-related mortality in Switzerland. Journal of viral hepatitis, 25(2), pp. 152-160. Blackwell Science 10.1111/jvh.12803

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In order to accurately assess the burden of hepatitis C (HCV) and develop effective interventions, we must understand the magnitude and trends of mortality related to the disease. In the United States, HCV-related mortality is continuously increasing. We have no comparable data for Switzerland and other European countries, although a modelling study predicted a similar increase. We analysed time trends (1 January 1995-31 December 2014) in HCV-specific mortality rates in the Swiss general population using the death registry of the Swiss Federal Statistical Office (SFSO). We compared HCV-related mortality to HIV-related and hepatitis B (HBV)-related mortality. To determine potential under-reporting in HCV-related mortality, we probabilistically linked the SFSO data to persons who died in the Swiss Hepatitis C Cohort Study (SCCS). SFSO data showed that HCV-related mortality more than doubled between 1995 and 2003, but has since stabilized at ~2.5/100 000 person-years. Since 2000, HCV-related mortality has been higher than HIV-related mortality and was about fivefold higher in 2014. HBV-related mortality remained low at ~0.5/100 000 person-years. Of 4556 persons in the SCCS, 421 have died and 86.2% could be linked to the death registry. According to the SCCS, 133 deaths were HCV-related. HCV was not mentioned on the SFSO death certificate of 45% of these (n = 60/133). In conclusion, HCV-related mortality remained constant, possibly because quality of care was high, or because of under-reporting or because mortality has not yet increased. However, HCV-related mortality is now much higher than HIV- and HBV-related mortality, and under-reporting was common.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)
08 Faculty of Science > Department of Mathematics and Statistics > Institute of Mathematical Statistics and Actuarial Science
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie

UniBE Contributor:

Keiser, Olivia; Giudici, Fabio; Dufour, Jean-François; Brezzi, Matteo Guido Giuseppe; Bertisch, Barbara; Estill, Janne Anton Markus and Spörri, Adrian


600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services
500 Science > 510 Mathematics




Blackwell Science




Tanya Karrer

Date Deposited:

11 Jan 2018 11:45

Last Modified:

27 Oct 2019 22:02

Publisher DOI:


PubMed ID:


Additional Information:

Keiser and Giudici contributed equally to this work.

Uncontrolled Keywords:

HIV cohort hepatitis B hepatitis C mortality




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