Muscle membrane properties in A pig sepsis model: Effect of norepinephrine.

Boërio, Delphine; Corrêa, Thiago D; Jakob, Stephan; Ackermann, Karin A; Bostock, Hugh; Z'Graggen, Werner Josef (2018). Muscle membrane properties in A pig sepsis model: Effect of norepinephrine. Muscle & nerve, 57(5), pp. 808-813. John Wiley & Sons 10.1002/mus.26013

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INTRODUCTION

Sepsis-induced myopathy and critical illness myopathy are common causes of muscle weakness in intensive care patients. This study investigated the effect of different mean arterial blood pressure (MAP) levels on muscle membrane properties following experimental sepsis.

METHODS

Sepsis was induced with fecal peritonitis in 12 of 18 anesthetized and mechanically ventilated pigs. Seven were treated with a high (75-85 mmHg) and 5 were treated with a low (≥60 mmHg) MAP target for resuscitation. In septic animals, resuscitation was started 12 h after peritonitis induction, and muscle velocity recovery cycles were recorded 30 h later.

RESULTS

Muscles in the sepsis/high MAP group showed an increased relative refractory period and reduced early supernormality compared with the remaining septic animals and the control group, indicating membrane depolarization and/or sodium channel inactivation. The membrane abnormalities correlated positively with norepinephrine dose.

DISCUSSION

Norepinephrine may contribute to sepsis-induced abnormalities in muscle by impairing microcirculation. Muscle Nerve, 2017.

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5 Citations in Web of Science ®
6 Citations in Scopus

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