Sadowski, Samira Mercedes; Christ, Emanuel; Bedat, Benoit; Kollár, Attila; Karenovics, Wolfram; Perren, Aurel; Triponez, Frederic (2018). Nationwide multicenter study on the management of pulmonary neuroendocrine (carcinoid) tumors. Endocrine Connections, 7(1), pp. 8-15. BioScientifica 10.1530/EC-17-0271
|
Text
8.full.pdf - Published Version Available under License Creative Commons: Attribution-Noncommercial (CC-BY-NC). Download (669kB) | Preview |
Background/ Aim: To analyze the management and outcome of patients with primary typical (TC) and atypical lung carcinoids (AC) in Switzerland.
METHODS
Retrospective analysis of patients selected from a neuroendocrine tumor (NET) registry. Patients were divided into TC and AC according to pathology reports, and surgical procedures were grouped as wedge/ segmentectomy, lobectomy/ bi-lobectomy and pneumectomy. Survival analysis was performed using the Kaplan-Meier method and log-rank test.
RESULTS
Over 7 years, 113 pulmonary carcinoids (61.9% females, mean age 59.4 years) were included from 19 hospitals, with pathology data on Ki67 and necrosis incomplete in 16 cases. Eighty-three TC and 14 AC underwent surgical resection with a primary tumor size of median 14.5 range 1-80 mm and diagnosis was established in 55.8% at surgery. Mean follow-up was 30.2 23.1 months. Lobectomy was performed in 54.2% and wedge resection in 17.7% of cases. Six patients received additional systemic therapy. There was a trend for larger primary lesion size and a significantly higher rate of N2-N3 status in AC. Mean survival tended to be increased in patients with TC compared to AC (86.1 versus 48.4 months, p=0.06) and mean disease-free-interval after surgical resection was 74.1 and 48.3 months for TC and AC, respectively (p=0.74).
CONCLUSION
AC of the lung have a more malignant behavior and a trend to a worse outcome. The results of this registry reinforce the need for standardized histological diagnosis and inter-disciplinary therapeutic decision-making to improve the quality of care of patients with TC and AC.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition 04 Faculty of Medicine > Service Sector > Institute of Pathology 04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology |
UniBE Contributor: |
Christ, Emanuel, Kollár, Attila, Perren, Aurel |
Subjects: |
600 Technology > 610 Medicine & health 500 Science > 570 Life sciences; biology |
ISSN: |
2049-3614 |
Publisher: |
BioScientifica |
Language: |
English |
Submitter: |
Aurel Perren |
Date Deposited: |
20 Dec 2017 12:25 |
Last Modified: |
05 Dec 2022 15:08 |
Publisher DOI: |
10.1530/EC-17-0271 |
PubMed ID: |
29229628 |
BORIS DOI: |
10.7892/boris.108058 |
URI: |
https://boris.unibe.ch/id/eprint/108058 |
Actions (login required)
 |
Edit item |