Non-Invasive Assessment of Intra-Abdominal Pressure Using Ultrasound Guided Tonometry - a Proof-of-Concept Study.

Bloch, Andreas; Glas, Michael; Kohler, Andreas; Baumann, Ulrich; Jakob, Stephan (2018). Non-Invasive Assessment of Intra-Abdominal Pressure Using Ultrasound Guided Tonometry - a Proof-of-Concept Study. Shock, 50(6), pp. 684-688. Lippincott Williams & Wilkins 10.1097/SHK.0000000000001085

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BACKGROUND Intra-abdominal hypertension jeopardizes abdominal organ perfusion and venous return. Contemporary recognition of elevated intra-abdominal pressure (IAP) plays a crucial role in reducing mortality and morbidity. We evaluated ultrasound guided tonometry in this context hypothesizing that the vertical chamber diameter of this device inversely correlates with intra-abdominal pressure. METHODS IAP was increased in six 5 mmHg steps to 40 mmHg by instillation of normal saline into the peritoneal cavity of eight anesthetized pigs. Liver and renal blood flows (ultrasound transit time), intra-vesical, intra-peritoneal and end-inspiratory plateau pressures were recorded. For ultrasound-based assessment of intra-abdominal pressure (ultrasound guided tonometry), a pressure transducing, compressible chamber was fixed at the tip of a linear ultrasound probe, and the system was applied on the abdominal wall using different pre-determined levels of external pressure. At each IAP level (reference: intra-vesical pressure), two investigators measured the vertical diameter of this chamber. RESULTS All abdominal flows decreased (by 39% to 58%), and end-inspiratory plateau pressure increased from 15 mbar (14-17 mbar) to 38 mbar (33-42 mbar) (median, range) with increasing IAP (all p < 0.01). Vertical chamber diameter decreased from 14.9 (14.6-15.2) mm to12.8 (12.4-13.4) mm with increasing IAP. Coefficients of variations between and within observers regarding change of the vertical tonometry chamber diameter were small (all < 4%), and the results were independent of the externally applied pressure level on the ultrasound probe. Correlation of IAP and vertical pressure chamber distance was highly significant (r: -1, p: 0.0004). Ultrasound guided tonometry could discriminate between normal (baseline) pressure and 15 mmHg, between 15 and 25mmHg) and between 25 and 40 mmHg IAP (all p≤0.18). Similar results were obtained for end-inspiratory plateau pressures. CONCLUSIONS In our model, values obtained by ultrasound guided tonometry correlated significantly with intra-abdominal pressures. The method was able to discriminate between normal, moderately and markedly increased IAP values.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Viszeralchirurgie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Viszeralchirurgie

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Visceral Surgery
04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic of Intensive Care

UniBE Contributor:

Bloch, Andreas; Glas, Michael; Kohler, Andreas and Jakob, Stephan

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1073-2322

Publisher:

Lippincott Williams & Wilkins

Language:

English

Submitter:

Mirella Aeberhard

Date Deposited:

16 Jan 2018 08:52

Last Modified:

22 Oct 2019 20:20

Publisher DOI:

10.1097/SHK.0000000000001085

PubMed ID:

29251669

BORIS DOI:

10.7892/boris.108685

URI:

https://boris.unibe.ch/id/eprint/108685

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