Lower exhaled nitric oxide in infants with Cystic Fibrosis compared to healthy controls.

Korten, Insa Christina Severine; Liechti, Margot; Singer, Florian; Hafen, Gaudenz; Rochat, Isabelle; Anagnostopoulou, Pinelopi; Müller-Suter, Dominik; Usemann, Jakob; Moeller, Alexander; Frey, Urs; Latzin, Philipp; Casaulta, Carmen (2018). Lower exhaled nitric oxide in infants with Cystic Fibrosis compared to healthy controls. Journal of cystic fibrosis, 17(1), pp. 105-108. Elsevier 10.1016/j.jcf.2017.05.005

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Exhaled nitric oxide (FENO) is a well-known, non-invasive airway biomarker. In patients with Cystic Fibrosis (CF) FENO is decreased. To understand if reduced FENO is primary related to Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) dysfunction or an epiphenomenon of chronic inflammation, we measured FENO in 34 infants with CF prior to clinical symptoms and in 68 healthy controls. FENO was lower in CF compared to controls (p=0.0006) and the effect was more pronounced in CF infants without residual CFTR function (p<0.0001). This suggests that FENO is reduced in CF early in life, possibly associated with underlying CFTR dysfunction.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine > Paediatric Pneumology

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Korten, Insa Christina Severine; Singer, Florian; Anagnostopoulou, Pinelopi; Latzin, Philipp and Casaulta, Carmen

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1569-1993

Publisher:

Elsevier

Language:

English

Submitter:

Romy Melanie Rodriguez Del Rio

Date Deposited:

16 Apr 2018 15:32

Last Modified:

23 Jan 2019 14:33

Publisher DOI:

10.1016/j.jcf.2017.05.005

PubMed ID:

28716479

BORIS DOI:

10.7892/boris.109244

URI:

https://boris.unibe.ch/id/eprint/109244

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