Advances and challenges in cirrhosis and portal hypertension.

Berzigotti, Annalisa (2017). Advances and challenges in cirrhosis and portal hypertension. BMC medicine, 15(1), p. 200. BioMed Central 10.1186/s12916-017-0966-6

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BACKGROUND Liver cirrhosis is the fourth cause of death in adults in Western countries, with complications of portal hypertension being responsible for most casualties. In order to reduce mortality, development of accurate diagnostic methods for early diagnosis, effective etiologic treatment, improved pharmacological therapy for portal hypertension, and effective therapies for end-stage liver failure are required. DISCUSSION Early detection of cirrhosis and portal hypertension is now possible using simple non-invasive methods, leading to the advancement of individualized risk stratification in clinical practice. Despite previous assumptions, cirrhosis can regress if its etiologic cause is effectively removed. Nevertheless, while this is now possible for cirrhosis caused by chronic hepatitis C, the incidence of cirrhosis due to non-alcoholic steatohepatitis has increased dramatically and effective therapies are not yet available. New drugs acting on the dynamic component of hepatic vascular resistance are being studied and will likely improve the future management of portal hypertension. CONCLUSION Cirrhosis is now seen as a dynamic disease able to progress and regress between the compensated and decompensated stages. This opinion article aims to provide the author's personal view of the current major advances and challenges in this field.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology

UniBE Contributor:

Berzigotti, Annalisa

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1741-7015

Publisher:

BioMed Central

Language:

English

Submitter:

Thi Thao Anh Pham

Date Deposited:

30 Jan 2018 15:59

Last Modified:

30 Jan 2018 16:08

Publisher DOI:

10.1186/s12916-017-0966-6

PubMed ID:

29121925

Uncontrolled Keywords:

Hepatic venous pressure gradient Liver stiffness Non-invasive methods Therapy Transjugular intrahepatic portosystemic shunt

BORIS DOI:

10.7892/boris.109575

URI:

https://boris.unibe.ch/id/eprint/109575

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