Hyperintensity of Cerebrospinal Fluid on T2-Weighted Fluid-Attenuated Inversion Recovery Magnetic Resonance Imaging Caused by High Inspired Oxygen Fraction.

Moioli, Melania; Levionnois, Olivier; Stein, Veronika Maria; Schüpbach, Gertraud; Schmidhalter, Marta; Schweizer, Daniela Esther (2017). Hyperintensity of Cerebrospinal Fluid on T2-Weighted Fluid-Attenuated Inversion Recovery Magnetic Resonance Imaging Caused by High Inspired Oxygen Fraction. Frontiers in veterinary science, 4(219), p. 219. Frontiers Media 10.3389/fvets.2017.00219

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In veterinary medicine, patients undergo magnetic resonance imaging (MRI) under general anesthesia to enable acquisition of artifact-free images. The fraction of inspired oxygen (FiO2) ranges between 30 and 95%. In humans, a high FiO2 is associated with incomplete signal suppression of peripheral cerebrospinal fluid (CSF) spaces on T2-weighted fluid-attenuated inversion recovery (T2w-FLAIR) sequences. The influence of FiO2 on T2w-FLAIR images remains unreported in small animals. The aim of this prospective study was to investigate whether a high FiO2 is associated with hyperintensity in peripheral CSF spaces on T2w-FLAIR images in dogs and cats. Client-owned patients undergoing brain MRI were prospectively enrolled. Animals with brain parenchymal abnormalities and/or meningeal contrast enhancement on MRI images and/or abnormal CSF analysis were excluded. Consequently, twelve patients were enrolled. Anesthesia was maintained by isoflurane 0.5-1 minimal alveolar concentration in 30% oxygen. After acquisition of transverse and dorsal T2w-FLAIR images, the FiO2 was increased to 95%. The T2w-FLAIR sequences were then repeated after 40 min. Arterial blood gas analysis was performed in six patients at the same time as T2w-FLAIR sequence acquisition. Plot profiles of the signal intensity (SI) from CSF spaces of three cerebral sulci and adjacent gray and white matter were generated. SI ratios of CSF space and white matter were compared between the T2w-FLAIR images with 30 and 95% FiO2. An observer blinded to the FiO2, subjectively evaluated the SI of peripheral CSF spaces on T2w-FLAIR images as high or low. There was significant difference in the partial pressure of oxygen between the two arterial samples (P < 0.001). The SI ratios obtained from the T2w-FLAIR images with 95% FiO2 were significantly higher compared with those obtained from the T2w-FLAIR images with 30% FiO2 (P < 0.05). The peripheral CSF spaces were subjectively considered hyperintense in 11 of 12 cases on T2w-FLAIR images with 95% FiO2 (P < 0.005). A clear difference in SI, dependent on the FiO2 was seen in the peripheral CSF spaces on T2w-FLAIR images. In conclusion, the influence of FiO2 must be considered when differentiating pathological and normal CSF spaces on T2w-FLAIR images in dogs and cats.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Research Foci > NeuroCenter
05 Veterinary Medicine > Research Foci > Veterinary Public Health / Herd Health Management
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Clinical Neurology
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV)
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Clinical Radiology
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Veterinary Public Health Institute
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH)
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Anaesthesiology

UniBE Contributor:

Moioli, Melania; Levionnois, Olivier; Stein, Veronika Maria; Schüpbach, Gertraud; Schmidhalter, Marta and Schweizer, Daniela Esther

Subjects:

600 Technology > 630 Agriculture
500 Science > 570 Life sciences; biology

ISSN:

2297-1769

Publisher:

Frontiers Media

Language:

English

Submitter:

Susanne Agnes Lerch

Date Deposited:

02 May 2018 09:03

Last Modified:

24 Oct 2019 04:09

Publisher DOI:

10.3389/fvets.2017.00219

PubMed ID:

29326953

Uncontrolled Keywords:

T2-weighted fluid-attenuated inversion recovery brain cat cerebrospinal fluid dog magnetic resonance imaging oxygen

BORIS DOI:

10.7892/boris.110140

URI:

https://boris.unibe.ch/id/eprint/110140

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