How nutrition and the maternal microbiota shape the neonatal immune system.

Macpherson, Andrew; Gomez de Agüero Tamargo, Maria de la Mercedes; Ganal-Vonarburg, Stephanie (2017). How nutrition and the maternal microbiota shape the neonatal immune system. Nature reviews - immunology, 17(8), pp. 508-517. Nature Publishing Group 10.1038/nri.2017.58

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The mucosal surfaces of mammals are densely colonized with microorganisms that are commonly referred to as the commensal microbiota. It is believed that the fetus in utero is sterile and that colonization with microorganisms starts only after birth. Nevertheless, the unborn fetus is exposed to a multitude of metabolites that originate from the commensal microbiota of the mother that reach systemic sites of the maternal body. The intestinal microbiota is strongly personalized and influenced by environmental factors, including nutrition. Members of the maternal microbiota can metabolize dietary components, pharmaceuticals and toxins, which can subsequently be passed to the developing fetus or the breast-feeding neonate. In this Review, we discuss the complex interplay between nutrition, the maternal microbiota and ingested chemicals, and summarize their effects on immunity in the offspring.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Gastroenterology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Gastroenterologie / Mukosale Immunologie

UniBE Contributor:

Macpherson, Andrew; Gomez de Agüero Tamargo, Maria de la Mercedes and Ganal-Vonarburg, Stephanie

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1474-1733

Publisher:

Nature Publishing Group

Language:

English

Submitter:

Thi Thao Anh Pham

Date Deposited:

01 Feb 2018 11:09

Last Modified:

01 Feb 2018 11:09

Publisher DOI:

10.1038/nri.2017.58

PubMed ID:

28604736

BORIS DOI:

10.7892/boris.110282

URI:

https://boris.unibe.ch/id/eprint/110282

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