Imaging biomarkers in liver fibrosis.

Berzigotti, Annalisa; França, M; Martí-Aguado, D; Martí-Bonmatí, L (2018). Imaging biomarkers in liver fibrosis. Radiología, 60(1), pp. 74-84. Elsevier Doyma 10.1016/j.rx.2017.09.003

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There is a need for early identification of patients with chronic liver diseases due to their increasing prevalence and morbidity-mortality. The degree of liver fibrosis determines the prognosis and therapeutic options in this population. Liver biopsy represents the reference standard for fibrosis staging. However, given its limitations and complications, different non-invasive methods have been developed recently for the in vivo quantification of fibrosis. Due to their precision and reliability, biomarkers' measurements derived from Ultrasound and Magnetic Resonance stand out. This article reviews the different acquisition techniques and image processing methods currently used in the evaluation of liver fibrosis, focusing on their diagnostic performance, applicability and clinical value. In order to properly interpret their results in the appropriate clinical context, it seems necessary to understand the techniques and their quality parameters, the standardization and validation of the measurement units and the quality control of the methodological problems.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology

UniBE Contributor:

Berzigotti, Annalisa

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0033-8338

Publisher:

Elsevier Doyma

Language:

Español

Submitter:

Thi Thao Anh Pham

Date Deposited:

19 Mar 2018 15:01

Last Modified:

27 May 2019 11:01

Publisher DOI:

10.1016/j.rx.2017.09.003

PubMed ID:

29108657

Uncontrolled Keywords:

Biomarcadores de imagen Elastografía por ecografía Elastografía por resonancia magnética Fibrosis hepática Imaging biomarkers Liver fibrosis Magnetic resonance elastography Quantitative magnetic resonance Resonancia magnética cuantitativa Ultrasound elastography

BORIS DOI:

10.7892/boris.110653

URI:

https://boris.unibe.ch/id/eprint/110653

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